Oral Administration of Insulin to Neonates Suppresses Spontaneous and Cyclophosphamide Induced Diabetes in the NOD Mouse

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

1999 • 633 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes

2000 • 456 citations

Oral Tolerance: Mechanisms and Therapeutic Applications

1999 • 318 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

1997 • 231 citations

Immune Responses to Fed Protein Antigens in Mice. 3. Systemic Tolerance or Priming Is Related to Age at Which Antigen Is First Encountered

1984 • 221 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein

1998 • 139 citations

DEVELOPMENT OF IMMUNE FUNCTION IN THE INTESTINE AND ITS ROLE IN NEONATAL DISEASES

1996 • 133 citations

Ontogeny of orally induced tolerance to soluble proteins in mice. I. Priming and tolerance in newborns.

1981 • 127 citations

Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals

1994 • 114 citations

Autoimmune Diabetes Induced by the β-cell Toxin STZ: Immunity to the 60-kDa Heat Shock Protein and to Insulin

1994 • 109 citations

Oral Administration of the Immunodominant B-chain of Insulin Reduces Diabetes in a Co-transfer Model of Diabetes in the NOD Mouse and is Associated with a Switch from Th1 to Th2 Cytokines

1997 • 109 citations

Introduction

1997 • 87 citations

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

1997 • 85 citations

gd T cells as mediators of mucosal tolerance: the autoimmune diabetes model

2000 • 85 citations

Neonatal Tolerization With Glutamic Acid Decarboxylase But Not With Bovine Serum Albumin Delays the Onset of Diabetes in NOD Mice

1994 • 81 citations

Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice.

1993 • 80 citations

A Critical Role for Cd40–Cd40 Ligand Interactions in Amplification of the Mucosal Cd8 T Cell Response

1999 • 79 citations

Protection Against Autoimmune Diabetes With Oral Insulin Is Associated With the Presence of IL-4 Type 2 T-Cells in the Pancreas and Pancreatic lymph Nodes

1998 • 74 citations

The case for elimination of cow's milk in early infancy in the prevention of type 1 diabetes: The finnish experience

1993 • 74 citations

The genetics and epidemiology of diabetes in NOD mice

1990 • 71 citations

Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

1999 • 69 citations

Neonatal Oral Tolerancea

1996 • 59 citations

Oral Tolerization Leads to Active Suppression and Bystander Tolerance in Adult Rats while Anergy Dominates in Young Rats

1996 • 50 citations

Neonatal induction of allogeneic tolerance prevents T cell‐mediated autoimmunity in NOD mice

1989 • 26 citations

Oral Tolerance to Insulin and the Insulin B‐Chain.

1996 • 16 citations

Dietary intervention for diabetes prevention in the neonate

1998 • 6 citations

Insulin as a target antigen in autoimmune diabetes: a natural repertoire as the source of antibody response

1994 • 3 citations

Intervention for diabetes prevention at neonatal age

1998 • 2 citations

Neonatal prevention of IDDM?

1998 • 2 citations

Intervention for diabetes prevention at neonatal age

1998 • 1 citations

Intervention for diabetes prevention at neonatal age in Japan

1998 • 1 citations

Intervention at neonatal age: can we intervene?

1998 • 1 citations