Role of Toll-Like Receptors in Pathogen Recognition

Innate Immune Recognition

2002 • 8,157 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 • 2,188 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

2000 • 2,023 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

2002 • 1,309 citations

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 • 1,305 citations

Discrimination of bacterial lipoproteins by Toll-like receptor 6

2001 • 1,222 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 • 1,060 citations

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

2002 • 1,028 citations

Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

1997 • 969 citations

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

2000 • 789 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

2001 • 759 citations

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

2000 • 744 citations

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

2001 • 730 citations

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 • 724 citations

Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster

2002 • 715 citations

Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli

2002 • 698 citations

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

2002 • 658 citations

Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging

2002 • 609 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

1995 • 590 citations

Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila

2002 • 576 citations

The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products

2000 • 484 citations

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

2001 • 477 citations

Three novel mammalian toll-like receptors: gene structure, expression, and evolution.

2000 • 470 citations

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

1999 • 445 citations

TLR6: A novel member of an expanding Toll-like receptor family

1999 • 437 citations

Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation

2000 • 432 citations

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

1999 • 429 citations

The domains of death: evolution of the apoptosis machinery

1999 • 406 citations

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

2001 • 398 citations

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

2001 • 393 citations

Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells

2001 • 388 citations

Proteins with leucine-rich repeats

1995 • 388 citations

A universal role for MyD88 in TLR/IL-1R-mediated signaling

2002 • 383 citations

Toll-related receptors and the control of antimicrobial peptide expression inDrosophila

2000 • 380 citations

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

2001 • 376 citations

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages.

1989 • 353 citations

Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease

2002 • 343 citations

Of mice and men: species variations of Toll-like receptor expression

2002 • 309 citations

Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children

2002 • 309 citations

Identification of Two Major Sites in the Type I Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways

2000 • 303 citations

Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans

1998 • 222 citations

Signaling mechanisms in the antimicrobial host defense of Drosophila

2000 • 217 citations

The Extracellular Toll-like Receptor 2 Domain Directly Binds Peptidoglycan Derived from Staphylococcus aureus

2002 • 188 citations

Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms

1993 • 159 citations

Mouse MD-1, a Molecule That Is Physically Associated with RP105 and Positively Regulates Its Expression

1998 • 150 citations

Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 MAPK signal pathways

2002 • 120 citations

The Drosophila Toll‐9 activates a constitutive antimicrobial defense

2002 • 114 citations

Soluble CD14 Truncated at Amino Acid 152 Binds Lipopolysaccharide (LPS) and Enables Cellular Response to LPS

1995 • 86 citations

From A to Z on CpG

2002 • 52 citations

The serine protease inhibitor antithrombin III inhibits LPS‐mediated NF‐κB activation by TLR‐4

2001 • 48 citations

Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells

2002 • 40 citations

TLR4-dependent lipopolysaccharide signalling in epithelial cells is independent of extracellular protease activity

2002 • 19 citations

Wanted

2002 • 18 citations