Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.

1994 • 318 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

A plant-based cholera toxin B subunit–insulin fusion protein protects against the development of autoimmune diabetes

1998 • 278 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

1997 • 231 citations

No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

2000 • 211 citations

ORAL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE DISEASES

1997 • 193 citations

Autoreactive CD4+ T Cells Protect from Autoimmune Diabetes via Bystander Suppression Using the IL-4/Stat6 Pathway

1999 • 184 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice

1998 • 163 citations

Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice.

1996 • 154 citations

DNA immunization to prevent autoimmune diabetes

1999 • 123 citations

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

2000 • 116 citations

Structural analysis of peptides capable of binding to more than one Ia antigen.

1989 • 112 citations

Antigen-Specific Mediated Suppression of β Cell Autoimmunity by Plasmid DNA Vaccination

2001 • 111 citations

Antigen-specific therapy for autoimmune disease

2000 • 107 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 98 citations

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

1997 • 90 citations

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.

1999 • 89 citations

Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses

2001 • 88 citations

Insulin in Oral Immune “Tolerance”: A One-Amino Acid Change in the B Chain Makes the Difference

1999 • 78 citations

Pathological Changes in the Islet Milieu Precede Infiltration of Islets and Destruction of β-Cells by Autoreactive Lymphocytes in a Transgenic Model of Virus-Induced IDDM

1997 • 71 citations

Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

1999 • 69 citations

Oral tolerance in the treatment of inflammatory autoimmune diseases

1999 • 58 citations

Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity?

1994 • 48 citations

Predictive Medicine in Autoimmune Diseases: From the Identification of Genetic Predisposition and Environmental Influence to Precocious Immunotherapy

1994 • 45 citations

A novel approach to the generation of high affinity class II-binding peptides.

1990 • 41 citations

Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

2000 • 38 citations

Cholera Toxin B Subunit as Transmucosal Carrier‐Delivery and Immunomodulating System for Induction of Antiinfectious and Antipathological Immunitya

1996 • 38 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 36 citations

Neither B Lymphocytes Nor Antibodies Directed Against Self Antigens of the Islets of Langerhans Are Required for Development of Virus-Induced Autoimmune Diabetes

2000 • 29 citations

T helper cell differentiation in multiple sclerosis and autoimmunity

1998 • 28 citations

The role of clonal deletion and anergy in oral tolerance

1997 • 27 citations

Oral Tolerance to Insulin and the Insulin B‐Chain.

1996 • 16 citations

Tolerance Induction with Agonist Peptides Recognized by Autoaggressive Lymphocytes is Transient: Therapeutic Potential for Type 1 Diabetes is Limited and Depends on Time-point of Administration, Choice of Epitope and Adjuvant

2001 • 11 citations

[Application of oral tolerance to the treatment of autoimmune diseases--active suppression and bystander suppression].

1997 • 1 citations