A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing Agent

1946 • 510 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

Identification ofEscherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure

1978 • 359 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

1994 • 317 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Studies on the Chemistry of Anaphylaxis (III). Experiments with Isolated Proteins, Especially those of the Hen's Egg

1911 • 211 citations

The induction of tolerance to a soluble protein antigen by oral administration.

1974 • 211 citations

Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.

1996 • 198 citations

Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats.

1986 • 176 citations

Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance

1989 • 164 citations

In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice.

1995 • 141 citations

Oral Administration of Human Insulin to NOD Mice Generates CD4+ T Cells that Suppress Adoptive Transfer of Diabetes

1994 • 137 citations

Suppression of experimental autoimmune myasthenia gravis by oral administration of acetylcholine receptor

1993 • 110 citations

Large-Scale Production of Vibrio cholerae Toxin B Subunit for Use in Oral Vaccines

1993 • 96 citations

Could specific oral tolerance be a therapy for autoimmune disease?

1990 • 95 citations

Orally Induced Tolerance

1981 • 91 citations

Genetic Control of Diabetogenesis in NOD/Lt Mice: Development and Analysis of Congenic Stocks

1989 • 88 citations

The Influence of Ether and Ether Anesthesia on Bacteriolysis, Agglutination, and Phagocytosis

1911 • 82 citations

Influence of Repeated Administration of Antigen by the Oral Route on Specific Antibody-Producing Cells in the Mouse Spleen

1973 • 77 citations

Inhibition of specific immune responses by feeding protein antigens. II. Effects of prior passive and active immunization.

1979 • 48 citations

The involvement of Ly 2+ T cells in beta cell destruction

1990 • 47 citations

Clinical and immunological response to oral and subcutaneous immunotherapy with grass pollen extracts

1982 • 37 citations

Pancreatic Lymph Nodes are Early Targets of T Cells during Adoptive Transfer of Diabetes in NOD Mice

1995 • 36 citations

Avian Ikaros gene is expressed early in embryogenesis

1997 • 34 citations

Inhibition of Specific Immune Responses by Feeding Protein Antigens

1979 • 31 citations

Oral hyposensitization of children with pollinosis or house-dust asthma.

1977 • 23 citations