Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group

1997 • 493 citations

Oral tolerance.

1994 • 456 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function.

1995 • 355 citations

Mouse NK1+ T cells

1995 • 292 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease.

1996 • 224 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

1997 • 208 citations

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

1996 • 207 citations

Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

1999 • 200 citations

Rat Annexin V Crystal Structure: Ca ²⁺ -Induced Conformational Changes

1993 • 191 citations

Critical role of NK1+ T cells in IL-12-induced immune responses in vivo.

1998 • 179 citations

The NK-1.1(-) mouse: a model to study differentiation of murine NK cells.

1986 • 165 citations

Strange brew: T cells in the liver

1996 • 163 citations

Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.

1997 • 136 citations

Cutting Edge: Critical Role of NK1+ T Cells in IL-12-Induced Immune Responses In Vivo

1998 • 136 citations

LPS induces NK1.1+ alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells.

1996 • 132 citations

Mouse liver T cells: Their change with aging and in comparison with peripheral T cells

1997 • 126 citations

Long Term Correction of Bilirubin-UDP-glucuronosyltransferase Deficiency in Gunn Rats by Administration of a Recombinant Adenovirus during the Neonatal Period

1996 • 117 citations

Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats.

1996 • 114 citations

Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat

1997 • 103 citations

Apoptosis of Neutrophils and Their Elimination by Kupffer Cells in Rat Liver

1996 • 93 citations

The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding

1989 • 90 citations

Kupffer cell production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion injury in rats

1996 • 86 citations

Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses

1998 • 85 citations

RAG1, RAG2 and pre‐T cell receptor α chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation

1996 • 76 citations

Common Mucosal Immune System and Strategies for the Development of Vaccines Effective at the Mucosal Surfaces

1994 • 73 citations

Kupffer Cell Production of Cytokine–Induced Neutrophil Chemoattractant Following Ischemia/Reperfusion Injury in Rats

1996 • 67 citations

Portal vein administration of donor cells promotes peripheral allospecific hyporesponsiveness and graft tolerance.

1994 • 61 citations

Permanent acceptance of liver allografts by intraportal injection of donor spleen cells in rats.

1992 • 59 citations

Development of CD4-CD8- alpha beta TCR+NK1.1+ T lymphocytes: thymic selection by self antigen.

1996 • 54 citations

Indirect Effects of Oral Tolerance Cannot be Ascribed to Bystander Suppression

1997 • 37 citations

Chemical Denaturation of Ovalbumin Abrogates the Induction of Oral Tolerance of Specific IgG Antibody and DTH Responses in Mice

1995 • 35 citations

Predominant appearance of NK1.1+ T cells producing IL-4 may be involved in the increased susceptibility of mice with the beige mutation during Salmonella infection.

1997 • 30 citations

Detection of cell-adhesion molecules on human liver-associated lymphocytes.

1994 • 13 citations

Treatment of experimental colitis through induction of oral tolerance towards colitis-extracted proteins

1998 • 12 citations

A critical role of the liver in inducing oral tolerance to adenoviral vectors for long-term gene therapy

1998 • 10 citations

Distinct cytotoxic lymphocytes subsets suggest a role for the liver in immune homeostasis

1998 • 3 citations

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