Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-gamma signaling pathway.

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Handbook of Mucosal Immunology

1994 • 711 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

1998 • 275 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

T cell clonal anergy

1997 • 257 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.

1989 • 178 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.

1995 • 167 citations

Aerosol-induced Immunoglobulin (Ig)-E Unresponsiveness to Ovalbumin Does Not Require CD8+ or T Cell Receptor (TCR)-γ/δ+ T Cells or Interferon (IFN)-γ in a Murine Model of Allergen Sensitization

1998 • 155 citations

In Situ Immune Response in Gut-Associated Lymphoid Tissue (GALT) Following Oral Antigen in TCR-Transgenic Mice

1998 • 145 citations

Direct measurement of anergy of antigen-specific T cells following oral tolerance induction.

1996 • 118 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

IL-12 Is an Effective Adjuvant for Induction of Mucosal Immunity

1999 • 110 citations

Inductive Events in Oral Tolerance in the TCR Transgenic Adoptive Transfer Model

1997 • 98 citations

CTLA-4 is required for the induction of high dose oral tolerance

1998 • 97 citations

Antigen-Specific T Cell Activation and Proliferation During Oral Tolerance Induction

1999 • 97 citations

Mechanisms of Oral Tolerance

1997 • 96 citations

Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice.

1998 • 81 citations

Regulation of transforming growth factor‐β production by interleukin‐12

1997 • 77 citations

Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines

1993 • 72 citations

Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance

1997 • 72 citations

Role of interleukin 12 and costimulators in T cell anergy in vivo

2009 • 71 citations

Persistence of Peptide-induced CD4+ T cell Anergy In Vitro

1998 • 62 citations

Transferable Anergy: Superantigen Treatment Induces CD4+ T Cell Tolerance That Is Reversible and Requires CD4−CD8− Cells and Interferon γ

1997 • 57 citations

Orally Induced Peripheral Nonresponsiveness Is Maintained in the Absence of Functional Th1 or Th2 Cells

1999 • 49 citations

The mucosal adjuvant effects of cholera toxin and immune-stimulating complexes differ in their requirement for IL-12, indicating different pathways of action

1999 • 47 citations

T-cell lymphokine response to orally administered proteins during priming and unresponsiveness.

1993 • 37 citations