An integrated view of cyclin E function and regulation

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

The Genomic Landscapes of Human Breast and Colorectal Cancers

2007 • 2,716 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

2000 • 1,275 citations

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

2001 • 1,107 citations

CDK Inhibitors: Cell Cycle Regulators and Beyond

2008 • 1,053 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

2007 • 1,003 citations

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

2002 • 940 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

1996 • 889 citations

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

2004 • 873 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

1999 • 787 citations

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

2002 • 778 citations

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

2004 • 758 citations

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

2011 • 744 citations

Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF ^Fbw7 Ubiquitin Ligase

2001 • 733 citations

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

2009 • 717 citations

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

2002 • 701 citations

Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication

2000 • 671 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

2003 • 635 citations

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

2011 • 587 citations

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

2001 • 575 citations

Inactivation of hCDC4 can cause chromosomal instability

2004 • 545 citations

Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.

1996 • 485 citations

Cyclin-dependent kinases regulate the antiproliferative function of Smads

2004 • 485 citations

Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase

2003 • 480 citations

Cyclin E in normal and neoplastic cell cycles

2005 • 476 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

2005 • 452 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases

2007 • 438 citations

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

2001 • 420 citations

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1999 • 388 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

2001 • 374 citations

p27 Phosphorylation by Src Regulates Inhibition of Cyclin E-Cdk2

2007 • 366 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation

2003 • 358 citations

Cell cycle–regulated phosphorylation of p220^NPATby cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

2000 • 356 citations

The Ubiquitin Ligase SCF ^Fbw7 Antagonizes Apoptotic JNK Signaling

2004 • 345 citations

Cdk-Inhibitory Activity and Stability of p27 Are Directly Regulated by Oncogenic Tyrosine Kinases

2007 • 329 citations

CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis

2005 • 327 citations

CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage

2006 • 325 citations

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

2009 • 313 citations

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

2008 • 308 citations

CP110, a Cell Cycle-Dependent CDK Substrate, Regulates Centrosome Duplication in Human Cells

2002 • 299 citations

Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A

1998 • 298 citations

A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

2004 • 290 citations

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

2004 • 279 citations

Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

2009 • 275 citations

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

2011 • 255 citations

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

2001 • 254 citations

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

2003 • 254 citations

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

2010 • 252 citations

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

2009 • 233 citations

Specific Phosphorylation of Nucleophosmin on Thr199 by Cyclin- dependent Kinase 2-Cyclin E and Its Role in Centrosome Duplication

2001 • 226 citations

A pathway in quiescent cells that controls p27^Kip1 stability, subcellular localization, and tumor suppression

2006 • 212 citations

A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry

2004 • 195 citations

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

2009 • 190 citations

Kinase-Independent Function of Cyclin E

2007 • 177 citations

SCF^Cdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

2008 • 171 citations

An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins

1991 • 170 citations

Involvement of Myc Activity in a G₁/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

2000 • 165 citations

Identification of CDK2 substrates in human cell lysates

2008 • 155 citations

Dynamics of Cdk1 Substrate Specificity during the Cell Cycle

2011 • 148 citations

Regulation of E2F transcription by cyclin E–Cdk2 kinase mediated through p300/CBP co-activators

2000 • 144 citations

Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase

2004 • 131 citations

Fbw7/hCDC4 dimerization regulates its substrate interactions.

2007 • 117 citations

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

2009 • 117 citations

Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

2008 • 112 citations

p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

2002 • 111 citations

Complete inhibition of Cdk/cyclin by one molecule of p21^Cip1

1998 • 108 citations

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

2010 • 106 citations

A mouse model for cyclin E-dependent genetic instability and tumorigenesis

2005 • 106 citations

Ubiquitylation of Cyclin E Requires the Sequential Function of SCF Complexes Containing Distinct hCdc4 Isoforms

2006 • 105 citations

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

2011 • 102 citations

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo

2008 • 94 citations

MicroRNA-223 Regulates Cyclin E Activity by Modulating Expression of F-box and WD-40 Domain Protein 7

2010 • 86 citations

Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas

2007 • 80 citations

A Feed-Forward Loop Involving Protein Kinase Cα and MicroRNAs Regulates Tumor Cell Cycle

2008 • 80 citations

Mcl-1 Ubiquitination and Destruction

2011 • 75 citations

Inactivation of E2F3 results in centrosome amplification

2003 • 73 citations

Overexpression of the Low Molecular Weight Cyclin E in Transgenic Mice Induces Metastatic Mammary Carcinomas through the Disruption of the ARF-p53 Pathway

2007 • 71 citations

Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry

2009 • 68 citations

A rough guide to a smooth brain

2000 • 64 citations

Ras activity regulates cyclin E degradation by the Fbw7 pathway

2005 • 61 citations

Constitutive Turnover of Cyclin E by Cul3 Maintains Quiescence

2007 • 61 citations

Disruption of TGF-β growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

2000 • 59 citations

A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo

2010 • 58 citations

Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27^Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling

2005 • 56 citations

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

2010 • 48 citations

Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines

2010 • 43 citations

High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas

2002 • 40 citations

Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland

2006 • 32 citations

Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells

2010 • 30 citations

Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis

2011 • 16 citations

Centrosomal localization of cyclins E and A

2011 • 13 citations

High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas

2002 • 2 citations