Overexpression of the Low Molecular Weight Cyclin E in Transgenic Mice Induces Metastatic Mammary Carcinomas through the Disruption of the ARF-p53 Pathway

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Deregulated cyclin E induces chromosome instability

1999 • 692 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

FVB/N: an inbred mouse strain preferable for transgenic analyses.

1991 • 600 citations

Cyclin E and Survival in Patients with Breast Cancer

2002 • 564 citations

Redundant cyclin overexpression and gene amplification in breast cancer cells.

1993 • 526 citations

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

2000 • 491 citations

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

2001 • 408 citations

Cyclin E, a Potential Prognostic Marker in Breast Cancer.

1997 • 346 citations

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

2004 • 279 citations

Induction of Mammary Gland Hyperplasia and Carcinomas in Transgenic Mice Expressing Human Cyclin E

1997 • 246 citations

Deregulation of cyclin E in breast cancer.

1995 • 227 citations

Tumor-Specific Proteolytic Processing of Cyclin E Generates Hyperactive Lower-Molecular-Weight Forms

2001 • 198 citations

Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53

1998 • 180 citations

Pathway Pathology

2002 • 166 citations

Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer

2004 • 153 citations

DNA Damage-Dependent Cell Cycle Checkpoints and Genomic Stability

2006 • 151 citations

p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

2002 • 111 citations

Overexpression of cyclin E protein is associated with specific mutation types in the p53 gene and poor survival in human breast cancer

2003 • 71 citations

The Tumor-specific Hyperactive Forms of Cyclin E Are Resistant to Inhibition by p21 and p27

2005 • 70 citations

Genetically engineered mouse models of mammary intraepithelial neoplasia.

2000 • 68 citations

Low-molecular-weight cyclin E: the missing link between biology and clinical outcome

2004 • 30 citations

Detection of Low Molecular Weight Derivatives of Cyclin E1 Is a Function of Cyclin E1 Protein Levels in Breast Cancer

2006 • 30 citations