Kinase-Independent Function of Cyclin E

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

1996 • 889 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

2003 • 781 citations

Deregulated cyclin E induces chromosome instability

1999 • 692 citations

Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

2000 • 689 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

Cdk2 Knockout Mice Are Viable

2003 • 638 citations

Cyclin E in normal and neoplastic cell cycles

2005 • 476 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Proliferation of cancer cells despite CDK2 inhibition

2003 • 458 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Cdc2–cyclin E complexes regulate the G1/S phase transition

2005 • 370 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation

2003 • 358 citations

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1999 • 340 citations

CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis

2005 • 327 citations

Formation of a Preinitiation Complex by S-phase Cyclin CDK-Dependent Loading of Cdc45p onto Chromatin

1998 • 326 citations

Assembly of a Complex Containing Cdc45p, Replication Protein A, and Mcm2p at Replication Origins Controlled by S-Phase Cyclin-Dependent Kinases and Cdc7p-Dbf4p Kinase

2000 • 322 citations

Distinct roles for cyclins E and A during DNA replication complex assembly and activation

2002 • 283 citations

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

2004 • 279 citations

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

2003 • 254 citations

A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry

2004 • 195 citations

DNA replication and progression through S phase

2005 • 192 citations

Recruitment of Phosphorylated Chromatin Assembly Factor 1 to Chromatin after UV Irradiation of Human Cells

1998 • 178 citations

Cyclin E2, a Novel G₁ Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human Cancers

1999 • 175 citations

Mcm2, but Not Rpa, Is a Component of the Mammalian Early G1-Phase Prereplication Complex

1999 • 174 citations

Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues

2005 • 158 citations

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles

2005 • 148 citations

Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle

1998 • 147 citations

Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F

1999 • 144 citations

The Roles of the MCM, ORC, and Cdc6 Proteins in Determining the Replication Competence of Chromatin in Quiescent Cells

2000 • 125 citations

Cyclin E Uses Cdc6 as a Chromatin-Associated Receptor Required for DNA Replication

2001 • 120 citations

Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

2002 • 120 citations

The Regulated Association of Cdt1 with Minichromosome Maintenance Proteins and Cdc6 in Mammalian Cells

2004 • 113 citations

p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

2002 • 111 citations

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins

1998 • 104 citations

Cdk2-dependent and -independent Pathways in E2F-mediated S Phase Induction

2000 • 91 citations

Xenopus cyclin E, a nuclear phosphoprotein, accumulates when oocytes gain the ability to initiate DNA replication

1996 • 44 citations

Bared essentials of CDK2 and cyclin E

2003 • 40 citations

HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5

1997 • 33 citations

Mammalian Mcm2/4/6/7 complex forms a toroidal structure

2003 • 32 citations