A pathway in quiescent cells that controls p27^Kip1 stability, subcellular localization, and tumor suppression

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Living with or without cyclins and cyclin-dependent kinases

2004 • 1,047 citations

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

2002 • 940 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1998 • 796 citations

p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

1999 • 787 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1999 • 702 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Regulation of the Cdk inhibitor p27 and its deregulation in cancer

2000 • 680 citations

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1999 • 593 citations

p27^Kip1 modulates cell migration through the regulation of RhoA activation

2004 • 487 citations

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

2004 • 398 citations

Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis

2004 • 361 citations

Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function

2000 • 357 citations

Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization

2002 • 348 citations

Mouse models for human lung cancer

2005 • 300 citations

p27Kip1: Regulation and Function of a Haploinsufficient Tumor Suppressor and Its Misregulation in Cancer

2001 • 295 citations

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

2001 • 291 citations

A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression

2002 • 281 citations

Phosphorylation of p27 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export

2002 • 267 citations

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

2001 • 254 citations

Degradation of p27 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway

2001 • 210 citations

Phosphorylation at Serine 10, a Major Phosphorylation Site of p27 , Increases Its Protein Stability

2000 • 209 citations

Novel p27^kip1 C-Terminal Scatter Domain Mediates Rac-Dependent Cell Migration Independent of Cell Cycle Arrest Functions

2002 • 206 citations

Regulation of the cytoskeleton: an oncogenic function for cdk inhibitors?

2004 • 187 citations

CRM1/Ran-Mediated Nuclear Export of p27^Kip1Involves a Nuclear Export Signal and Links p27 Export and Proteolysis

2003 • 178 citations

Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra

2000 • 144 citations

The Cyclin-dependent Kinase Inhibitor p27Kip1 Is Stabilized in G0 by Mirk/dyrk1B Kinase

2004 • 134 citations

A critical role for p27 ^kip1 gene dosage in a mouse model of prostate carcinogenesis

2004 • 122 citations

ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but Impaired in p27-Null Cells

2002 • 119 citations

Involvement of p21^Waf1/Cip1 in Protein Kinase C Alpha-Induced Cell Cycle Progression

2000 • 114 citations

Molecular Dissection of the Interaction between p27 and Kip1 Ubiquitylation-promoting Complex, the Ubiquitin Ligase That Regulates Proteolysis of p27 in G1 Phase

2005 • 86 citations

Phosphorylation of p27Kip1 at Thr-157 Interferes with Its Association with Importin α during G1 and Prevents Nuclear Re-entry

2004 • 82 citations

Wagging the Dogma

2004 • 77 citations

Role of Serine 10 Phosphorylation in p27 Stabilization Revealed by Analysis of p27 Knock-in Mice Harboring a Serine 10 Mutation

2004 • 69 citations

Disruption of TGF-β growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

2000 • 59 citations

Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27^Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling

2005 • 56 citations

Degradation of p27kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway

2004 • 42 citations

Ubiquitination of p27 Requires Physical Interaction with Cyclin E and Probable Phosphate Recognition by SKP2

2005 • 40 citations

Noncatalytic Requirement for Cyclin A-cdk2 in p27 Turnover

2004 • 39 citations