Mcl-1 Ubiquitination and Destruction

AKT/PKB Signaling: Navigating Downstream

2007 • 5,728 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

The Genomic Landscapes of Human Breast and Colorectal Cancers

2007 • 2,716 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

The Bcl-2 family: roles in cell survival and oncogenesis

2003 • 1,448 citations

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

2006 • 1,193 citations

Tenets of PTEN Tumor Suppression

2008 • 1,005 citations

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

2007 • 1,003 citations

The Anaphase-Promoting Complex

2002 • 885 citations

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

2004 • 873 citations

Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1

2006 • 837 citations

The PTEN–PI3K pathway: of feedbacks and cross-talks

2008 • 836 citations

Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis

2005 • 802 citations

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

2003 • 771 citations

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

2004 • 758 citations

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

2011 • 744 citations

Life in the balance: how BH3-only proteins induce apoptosis

2005 • 744 citations

Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF ^Fbw7 Ubiquitin Ligase

2001 • 733 citations

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

2003 • 588 citations

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

2011 • 587 citations

Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells

2005 • 569 citations

The anaphase-promoting complex: it's not just for mitosis any more

2002 • 494 citations

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

2004 • 485 citations

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

2007 • 469 citations

Oncogene addiction: setting the stage for molecularly targeted cancer therapy

2007 • 431 citations

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

2003 • 426 citations

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

2008 • 401 citations

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

2005 • 394 citations

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

2007 • 380 citations

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

2001 • 374 citations

Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization

2007 • 367 citations

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

2004 • 364 citations

Regulation of the cell cycle by SCF-type ubiquitin ligases

2005 • 355 citations

Mcl-1 is a potential therapeutic target in multiple types of cancer

2008 • 314 citations

Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

2008 • 258 citations

Regulation of the Cell Cycle at the G1–S Transition by Proteolysis of Cyclin E and p27Kip1

2001 • 241 citations

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

2009 • 183 citations

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

2007 • 176 citations

GSK-3β Inhibition Enhances Sorafenib-induced Apoptosis in Melanoma Cell Lines

2007 • 54 citations

Interwoven Ubiquitination Oscillators and Control of Cell Cycle Transitions

2004 • 47 citations

A Convoluted Way to Die

2001 • 25 citations