Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas

Mathematical Statistics and Data Analysis

1989 • 3,077 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

2003 • 1,066 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Hedgehog signalling in cancer formation and maintenance

2003 • 821 citations

Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF ^Fbw7 Ubiquitin Ligase

2001 • 733 citations

Deregulated cyclin E induces chromosome instability

1999 • 692 citations

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

2001 • 575 citations

Inactivation of hCDC4 can cause chromosomal instability

2004 • 545 citations

Focus on lung cancer

2002 • 491 citations

Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.

1996 • 485 citations

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

2001 • 420 citations

Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression.

1997 • 404 citations

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1999 • 388 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation

2003 • 358 citations

hCDC4 gene mutations in endometrial cancer.

2002 • 267 citations

Induction of Mammary Gland Hyperplasia and Carcinomas in Transgenic Mice Expressing Human Cyclin E

1997 • 246 citations

Mathematical Statistics and Data Analysis

1995 • 206 citations

Frequent requirement of hedgehog signaling in non-small cell lung carcinoma

2006 • 174 citations

Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice

1991 • 133 citations

Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development.

1999 • 124 citations

Mouse lung epithelial cell lines—tools for the study of differentiation and the neoplastic phenotype

1997 • 124 citations

Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.

2001 • 121 citations

Transgenic expression of PML/RARalpha impairs myelopoiesis.

1996 • 107 citations

A mouse model for cyclin E-dependent genetic instability and tumorigenesis

2005 • 106 citations

Mutation of hCDC4 Leads to Cell Cycle Deregulation of Cyclin E in Cancer

2004 • 96 citations

Prognostic significance of cyclin E overexpression in resected non-small cell lung cancer.

2000 • 88 citations

Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation.

1996 • 84 citations

A risk-stratification model of non-small cell lung cancers using cyclin E, Ki-67, and ras p21: different roles of G1 cyclins in cell proliferation and prognosis.

2001 • 66 citations

Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy

2004 • 62 citations

Mouse Models of Lung Cancer

2006 • 55 citations

Retinoic acid causes a decline in TGF-alpha expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line.

1990 • 48 citations

Targeting of PML/RAR Is Lethal to Retinoic Acid–Resistant Promyelocytic Leukemia Cells

1998 • 47 citations

Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc

1999 • 43 citations

Independent formation of DnaseI hypersensitive sites in the murine β-globin locus control region

2000 • 37 citations

Retinoid Targeting of Different D-Type Cyclins through Distinct Chemopreventive Mechanisms

2005 • 33 citations

Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: a comparison with human lung adenocarcinoma.

2002 • 24 citations

Targeting of PML/RAR Is Lethal to Retinoic Acid–Resistant Promyelocytic Leukemia Cells

1998 • 6 citations