Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

2002 • 1,442 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

1999 • 787 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1999 • 702 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1999 • 593 citations

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

2001 • 586 citations

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

2001 • 575 citations

The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

2001 • 467 citations

pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1995 • 460 citations

A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways

1999 • 427 citations

Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

2001 • 416 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 ^CIP1/WAF1 and cyclin D proteins

1998 • 401 citations

Proteasomal Turnover of p21Cip1 Does Not Require p21Cip1 Ubiquitination

2000 • 391 citations

A CDK-Independent Function of Mammalian Cks1

2001 • 356 citations

NEDD8 recruits E2-ubiquitin to SCF E3 ligase

2001 • 321 citations

Ubiquitination of p53 and p21 Is Differentially Affected by Ionizing and UV Radiation

1997 • 316 citations

Proteolysis and the cell cycle: with this RING I do thee destroy

2000 • 308 citations

Human Origin Recognition Complex Large Subunit Is Degraded by Ubiquitin-Mediated Proteolysis after Initiation of DNA Replication

2002 • 302 citations

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

1985 • 263 citations

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein–ubiquitin ligase SCF^Skp2

2002 • 257 citations

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 ^Kip1 by ubiquitination

2000 • 245 citations

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

2001 • 235 citations

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

1998 • 204 citations

Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

1998 • 147 citations

Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway

1999 • 121 citations

Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation

2002 • 90 citations

Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway

1999 • 86 citations

Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCFp45Skp2 pathway

2000 • 77 citations

The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein.

1995 • 74 citations

Functional receptors for vasoactive intestinal peptide in cultured vascular smooth muscle cells from rat aorta

1985 • 61 citations