Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.

1985 • 355 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains.

1989 • 225 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.

1992 • 170 citations

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

1988 • 144 citations

Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.

1992 • 136 citations

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.

1987 • 125 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.

1991 • 112 citations

Augmented Mitogenesis and Impaired Metabolic Signaling Mediated by a Truncated Insulin Receptor

1989 • 109 citations

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.

1992 • 107 citations

Receptor Binding and Tyrosine Kinase Activation by Insulin Analogues With Extreme Affinities Studied in Human Hepatoma HepG2 Cells

1991 • 94 citations

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus

1991 • 90 citations

Receptor Binding, Endocytosis, and Mitogenesis of Insulin‐Like Growth Factors I and II in Fetal Rat Brain Neurons

1991 • 83 citations

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties

1991 • 82 citations

The role of insulin receptor autophosphorylation in signal transduction.

1991 • 80 citations

Changing the insulin receptor to possess insulin-like growth factor I ligand specificity

1990 • 70 citations

Changes in tyrosine phosphorylation of insulin receptors and a 170,000 molecular weight nonreceptor protein in vivo in skeletal muscle of streptozotocin-induced diabetic rats: effects of insulin and glucose.

1992 • 65 citations

Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.

1992 • 58 citations

Functional receptors for insulin-like growth factors I and II in rat thymocytes and mouse thymoma cells

1989 • 52 citations

Human insulin-like growth factor I receptor 950tyrosine is required for somatotroph growth factor signal transduction.

1992 • 45 citations

Peptide Hormone Action

1990 • 12 citations