Reciprocal Modulation of Binding of Lysosomal Enzymes and Insulin-Like Growth Factor-II (IGF-II) to the Mannose 6- Phosphate/IGF-II Receptor

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

1988 • 363 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

1985 • 203 citations

The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.

1988 • 199 citations

Ligand interactions of the cation-independent mannose 6-phosphate receptor

1989 • 194 citations

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor.

1988 • 190 citations

Characterization of a membrane-associated receptor from bovine liver that binds phosphomannosyl residues of bovine testicular beta-galactosidase.

1981 • 176 citations

Biosynthesis and turnover of the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1983 • 169 citations

Possible Direct Linkage of Insulin-like Growth Factor-II Receptor with Guanine Nucleotide-binding Proteins

1989 • 169 citations

The receptor for insulin-like growth factor II mediates an insulin-like response.

1987 • 145 citations

Chicken and Xenopus Mannose 6-Phosphate Receptors Fail to Bind Insulin-like Growth Factor II

1989 • 137 citations

IGF-2 stimulated growth mediated by the somatomedin type 2 receptor

1987 • 121 citations

Interactions of Cathepsin-D and Insulin-Like Growth Factor-II (IGF-II) on the IGF-II/Mannose-6-Phosphate Receptor in Human Breast CancerCells and Possible Consequences on Mitogenic Activity of IGF-II

1990 • 119 citations

The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II

1989 • 110 citations

The Type II Insulin-Like Growth Factor Receptor Does Not Mediate Deoxyribonucleic Acid Synthesis in Human Fibroblasts*

1987 • 108 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Insulin-like growth factor-II (IGF-II) inhibits both the cellular uptake of β-galactosidase and the binding of β-galactosidase to purified IGF-II/mannose 6-phosphate receptor

1989 • 94 citations

Mannose 6-phosphate/insulin-like growth factor II receptor: Distinct binding sites for mannose 6-phosphate and insulin-like growth factor II

1988 • 91 citations

Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor

1987 • 89 citations

The mannose 6-phosphate receptor of Chinese Hamster ovary cells. Isolation of mutants with altered receptors.

1981 • 77 citations

Insulin-like growth factor II stimulates production of inositol trisphosphate in proximal tubular basolateral membranes from canine kidney.

1988 • 75 citations

Evidence that type II insulin-like growth factor receptor is coupled to calcium gating system

1988 • 72 citations

Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells.

1990 • 66 citations

β‐Galactosidase decreases the binding affinity of the insulin‐like‐growth‐factor‐II/mannose‐6‐phosphate receptor for insulin‐like‐growth‐factor II

1990 • 50 citations

Mannose 6-phosphate increases the affinity of its cation-independent receptor for insulin-like growth factor II by displacing inhibitory endogenous ligands

1988 • 24 citations

Biosynthesis of the Insulin-Like Growth Factor-II (IGF-II)/Mannose-6-Phosphate Receptor in Rat C6 Glial Cells: The Role ofN-Linked Glycosylation in Binding of IGF-II to the Receptor

1991 • 20 citations

Parallel effects of insulin-like growth factor-II and insulin on glucose metabolism of developing mouse embryonic limb buds in culture

1988 • 19 citations