Cellular trafficking and processing of the insulin receptor ¹

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Lysosomotropic agents

1974 • 1,887 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

1983 • 445 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Structure of the human insulin receptor gene and characterization of its promoter.

1989 • 349 citations

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

1990 • 312 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor.

1982 • 225 citations

Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits.

1983 • 216 citations

Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes.

1984 • 207 citations

Vesicular stomatitis virus and sindbis virus glycoprotein transport to the cell surface is inhibited by ionophores

1980 • 198 citations

Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes.

1977 • 174 citations

Rapid, reversible internalization of cell surface insulin receptors. Correlation with insulin-induced down-regulation.

1983 • 159 citations

Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin.

1985 • 146 citations

Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules.

1989 • 142 citations

Insulin-induced down-regulation of insulin receptors in 3T3-L1 adipocytes. Altered rate of receptor inactivation.

1982 • 139 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Internalization and Activation of the Rat Liver Insulin Receptor Kinase in vivo

1989 • 116 citations

Myristyl and palmityl acylation of the insulin receptor.

1987 • 114 citations

Characterization of rat liver endosomal fractions. In vivo activation of insulin-stimulable receptor kinase in these structures.

1986 • 107 citations

Selective degradation of insulin within rat liver endosomes.

1990 • 106 citations

Post-translational changes in tertiary and quaternary structure of the insulin proreceptor. Correlation with acquisition of function.

1988 • 105 citations

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.

1982 • 102 citations

Isolation of insulin degradation products from endosomes derived from intact rat liver.

1988 • 99 citations

Control of insulin receptor level in 3T3 cells: effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation.

1982 • 96 citations

Degradation products of insulin generated by hepatocytes and by insulin protease.

1988 • 95 citations

Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase.

1990 • 93 citations

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

1989 • 90 citations

The Insulin Receptor: Structure and Functio

1989 • 90 citations

The Development of Insulin Receptors and Responsiveness Is an Early Marker of Differentiation in the Muscle Cell Line L6*

1986 • 81 citations

Tyrosine Phosphorylation of the Insulin Receptor During Insulin-stimulated Internalization in Rat Hepatoma Cells

1989 • 81 citations

Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding

1989 • 80 citations

Identification of a Ligand-Binding Region of the Human Insulin Receptor Encoded by the Second Exon of the Gene

1990 • 79 citations

Characterization of the Promoter Region and 3′ End of the Human Insulin Receptor Gene

1989 • 74 citations

Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes.

1982 • 72 citations

Affinity alteration of insulin receptor induced by a phorbol ester

1982 • 65 citations

The effects of cycloheximide and chloroquine on insulin receptor metabolism. Differential effects on receptor recycling and inactivation and insulin degradation.

1985 • 62 citations

Insulin receptor kinase following internalization in isolated rat adipocytes.

1987 • 57 citations

Evidence for Two Independent Pathways of Insulin-Receptor Internalization in Hepatocytes and Hepatoma Cells

1988 • 57 citations

Hormonal regulation of insulin receptor gene expression. Hydrocortisone and insulin act by different mechanisms.

1988 • 50 citations

Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.

1989 • 49 citations

A common mechanism for posttranslational activation of plasma membrane receptors?

1989 • 45 citations

Insulin down-regulates insulin receptor number and up-regulates insulin receptor affinity in cells expressing a tyrosine kinase-defective insulin receptor.

1990 • 45 citations

Regulation of Insulin-Receptor mRNA Levels by Glucocorticoids

1987 • 42 citations

The Insulin Receptor of a Human Monocyte-Like Cell Line: Characterization and Function*

1984 • 41 citations

Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.

1990 • 37 citations

Endocytosis, Recycling, and Degradation of the Insulin Receptor

1989 • 36 citations

Effects of Growth and Insulin Treatment on the Levels of Insulin Receptors and Their mRNA in HEP G2 Cells

1989 • 36 citations

Ultrastructural analysis of the organization and distribution of insulin receptors on the surface of 3T3‐L1 adipocytes: Rapid microaggregation and migration of occupied receptors

1985 • 33 citations

Labile disulfide bonds in human placental insulin receptor.

1990 • 32 citations

Differences in Adenosine Triphosphate Dependency of Receptor-Mediated Endocytosis of α2-Macroglobulin and Insulin Correlate with Separate Routes of Ligand-Receptor Complex Internalization*

1990 • 32 citations

Effects of monensin on insulin interactions with isolated hepatocytes. Evidence for inhibition of receptor recycling and insulin degradation

1986 • 30 citations

The acute and chronic effects of glucocorticoids on insulin receptor and insulin responsiveness. Transient fluctuations in intracellular receptor level parallel transient fluctuations in responsiveness.

1986 • 26 citations

Insulin receptor internalization and recycling: mechanism and significance

1985 • 24 citations

[125I]-Insulin metabolism by the rat liver in vivo: Evidence that a neutral thiol-protease mediates rapid intracellular insulin degradation

1990 • 17 citations

Homologous down-regulation of the insulin receptor is associated with increased receptor biosynthesis in cultured human lymphocytes (IM-9 line).

1987 • 17 citations

Evidence for an early degradative event to the insulin molecule following binding to hepatocyte receptors

1986 • 15 citations

Peptide mapping of the insulin-binding site of the 130-kDa subunit of the insulin receptor by means of a novel cleavable radioactive photoprobe

1985 • 13 citations

Uncoupling between the insulin-receptor cycle and the cellular degradation of the hormone in cultured foetal hepatocytes. Effect of drugs and temperature that inhibit insulin degradation

1987 • 7 citations

Insulin binding and processing by H4IIEC3 hepatoma cells: Ultrastructural and biochemical evidence for a unique route of internalization and processing

1987 • 6 citations

Degradation of insulin receptors by hepatoma cells: insulin-induced down-regulation results from an increase in the rate of basal receptor degradation

1985 • 6 citations

Internalization of Insulin: Structures Involved and Significance

1985 • 5 citations