Urokinase Receptor and Fibronectin Regulate the ERKMAPK to p38MAPK Activity Ratios That Determine Carcinoma Cell Proliferation or Dormancy In Vivo

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly

1998 • 589 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling

1999 • 520 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

1998 • 336 citations

Fibronectin and integrins in invasion and metastasis

1995 • 315 citations

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

1998 • 309 citations

Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly

1999 • 303 citations

Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

1998 • 264 citations

Adhesion molecules in cancer: the role of integrins

1993 • 264 citations

Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

1998 • 234 citations

Transplantable human neoplasms maintained in cortisone-treated laboratory animals: H.S. No. 1; H.Ep. No. 1; H.Ep. No. 2; H.Ep. No. 3; and H.Emb.Rh. No. 1.

1954 • 231 citations

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

1997 • 193 citations

Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK

1997 • 191 citations

Deregulation of the signaling pathways controlling urokinase production

1999 • 189 citations

Reduction in Surface Urokinase Receptor Forces Malignant Cells into a Protracted State of Dormancy

1997 • 158 citations

One-way Cross-talk between p38MAPK and p42/44MAPK

1999 • 152 citations

p38 Kinase Is a Negative Regulator of Angiotensin II Signal Transduction in Vascular Smooth Muscle Cells

1998 • 131 citations

Bidirectional Regulation of p38 Kinase and c-Jun N-terminal Protein Kinase by Insulin-like Growth Factor-I

1998 • 114 citations

Changes in malignant phenotype of a human carcinoma conditioned by growth environment

1983 • 106 citations

Cell Cycle Arrest and Reversion of Ras-Induced Transformation by a Conditionally Activated Form of Mitogen-Activated Protein Kinase Kinase Kinase 3

1999 • 86 citations

Regulation by p38 mitogen-activated protein kinase of adenylate- and uridylate-rich element-mediated urokinase-type plasminogen activator (uPA) messenger RNA stability and uPA-dependent in vitro cell invasion.

1999 • 83 citations

Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade

1997 • 70 citations

Role of the alpha 5 beta 1 integrin receptor in the proliferative response of quiescent human melanoma cells to fibronectin.

1992 • 57 citations

Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin.

1996 • 54 citations

Fibronectin Fibrils and Growth Factors Stimulate Anchorage-Independent Growth of a Murine Mammary Carcinoma

1996 • 35 citations

A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis.

1998 • 33 citations

Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells

1998 • 32 citations

Loss of the tumorigenic phenotype with in vitro, but not in vivo, passaging of a novel series of human bronchial epithelial cell lines: possible role of an alpha 5/beta 1-integrin-fibronectin interaction.

1995 • 31 citations

A Novel Mechanism of Ha-ras Oncogene Action: Regulation of Fibronectin mRNA Levels by a Nuclear Posttranscriptional Event

1994 • 29 citations

Cleavage of urokinase receptor regulates its interaction with integrins in thyroid cells

1999 • 28 citations

A novel mechanism of Ha-ras oncogene action: regulation of fibronectin mRNA levels by a nuclear posttranscriptional event.

1994 • 19 citations

Transcriptional Repression of Fibronectin Gene Expression in v-src Transformation

1995 • 9 citations

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