Molecular Detection of Circulating Cancer Cells

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

2001 • 747 citations

Detection and characterization of carcinoma cells in the blood

1998 • 684 citations

The significance of hematogenous tumor cell clumps in the metastatic process.

1976 • 568 citations

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

1992 • 563 citations

Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival

1994 • 413 citations

Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies.

1987 • 316 citations

Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients.

2001 • 239 citations

Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR.

1997 • 224 citations

Are lymph node micrometastases of any clinical significance in dukes stages A and B colorectal cancer?

1998 • 163 citations

The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptase-polymerase-chain reaction is related to the stage of disease

1996 • 160 citations

Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

2000 • 145 citations

Immunomagnetic enrichment of disseminated epithelial tumor cells from peripheral blood by MACS.

1998 • 143 citations

Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells

2002 • 130 citations

Prognostic Significance of Cytokeratin-20 Reverse Transcriptase Polymerase Chain Reaction in Lymph Nodes of Node-Negative Colorectal Cancer Patients

2002 • 129 citations

Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20

1998 • 128 citations

Increased detection of circulating tumor cells in the blood of colorectal carcinoma patients using two reverse transcription-PCR assays and multiple blood samples.

1999 • 107 citations

Clearance of Circulating Tumor Cells After Excision of Primary Colorectal Cancer

2002 • 104 citations

Detection and enumeration of circulating tumour cells in colorectal cancer

1993 • 89 citations

Molecular detection of telomerase-positive circulating epithelial cells in metastatic breast cancer patients.

1999 • 88 citations

Detection and analysis of cancer cells in blood and bone marrow using a rare event imaging system.

2000 • 76 citations

Incidence and Prognostic Implications of Isolated Tumor Cells in Lymph Nodes from Patients with Dukes B Colorectal Carcinoma

2002 • 65 citations

Detection of p16 promoter hypermethylation in serum of gastric cancer patients

2003 • 53 citations

Quantitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes.

2001 • 52 citations

High Percentage of False-Positive Results of Cytokeratin 19 RT-PCR in Blood: A Model for the Analysis of Illegitimate Gene Expression

2000 • 49 citations

Ectopic Expression of Guanylyl Cyclase C in CD34⁺ Progenitor Cells in Peripheral Blood

2001 • 45 citations

Real-time PCR (TaqMan PCR) quantification of carcinoembryonic antigen (CEA) mRNA in the peripheral blood of colorectal cancer patients.

2003 • 32 citations

Immunomagnetic Enrichment and Detection of Micrometastases in Colorectal Cancer: Correlation With Established Clinical Parameters

2002 • 31 citations

Immunobead RT-PCR versus regular RT-PCR amplification of CEA mRNA in peripheral blood

2001 • 28 citations

Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review)

2001 • 28 citations

Transcription of Cytokeratins 8, 18, and 19 in Bone Marrow and Limited Expression of Cytokeratins 7 and 20 by Carcinoma Cells: Inherent Limitations for RT-PCR in the Detection of Isolated Tumor Cells

2001 • 27 citations

Comparison of the expression profile of metastasis-associated genes between primary and circulating cancer cells in oral squamous cell carcinoma.

2003 • 26 citations

Reliability of quantitative reverse-transcriptase-PCR-based detection of tumour cells in the blood between different laboratories using a standardised protocol

2003 • 26 citations

Effects of whole body hyperthermia (41.8 degrees C) on the frequency of tumor cells in the peripheral blood of patients with advanced malignancies.

2003 • 21 citations

Effect of Blood Sample Handling and Reverse Transcriptase–Polymerase Chain Reaction Assay Sensitivity on Detection of CK20 Expression in Healthy Donor Blood

2002 • 20 citations

Quantitative Reverse Transcription-PCR Comparison of Tumor Cell Enrichment Methods

2001 • 19 citations

Detection of cancer metastases in regional lymph nodes: comparative histological and immunohistological investigations with the broad-range anticytokeratin monoclonal antibody A45-B/B3.

1991 • 16 citations

Detection of colorectal cancer cells in peripheral blood by reverse‐transcriptase polymerase chain reaction for cytokeratin 20

1998 • 14 citations

Cytokeratin-positive cells in preoperative peripheral blood and bone marrow aspirates of patients with colorectal cancer

2002 • 11 citations

Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

2000 • 7 citations

Detecting disseminated solid tumor cells in hematopoietic samples: methodological aspects

2001 • 7 citations

A Novel Method for Monitoring Response to Chemotherapy Based on the Detection of Circulating Cancer Cells: A Case Report

2002 • 7 citations

Gastrointestinal Cancer: Towards a Tailored Tumour Therapy

2003 • 4 citations