Minimal Residual Disease in Gastric Cancer: Evidence of an Independent Prognostic Relevance of Urokinase Receptor Expression by Disseminated Tumor Cells in the Bone Marrow

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Regression Models and Life-Tables

1992 • 27,454 citations

Regression Models and Life-Tables

1972 • 27,145 citations

A Simple Sequentially Rejective Multiple Test Procedure

1979 • 20,726 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

1992 • 563 citations

Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial.

1998 • 530 citations

Differential Expression of Proliferation-Associated Molecules in Individual Micrometastatic Carcinoma Cells

1993 • 514 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases.

1991 • 454 citations

Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells

1999 • 449 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Urokinase Receptor and Fibronectin Regulate the ERK^MAPK to p38^MAPK Activity Ratios That Determine Carcinoma Cell Proliferation or Dormancy In Vivo

2001 • 422 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Prognostic Value of Immunohistochemically Identifiable Tumor Cells in Lymph Nodes of Patients with Completely Resected Esophageal Cancer

1997 • 370 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes.

1995 • 355 citations

Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies.

1987 • 316 citations

Methodological Analysis of Immunocytochemical Screening for Disseminated Epithelial Tumor Cells in Bone Marrow

1994 • 312 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis.

1992 • 289 citations

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

1990 • 278 citations

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.

1994 • 266 citations

Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

1995 • 253 citations

The epithelial cell surface antigen 17–1A, a target for antibody‐mediated tumor therapy: Its biochemical nature, tissue distribution and recognition by different monoclonal antibodies

1986 • 243 citations

Prognostic Value of Immunocytologic Detection of Bone Marrow Metastases in Neuroblastoma

1991 • 238 citations

The regulation and expression of MHC class I genes

1990 • 237 citations

Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated.

1998 • 228 citations

Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells.

1991 • 227 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Bone marrow micrometastases in primary breast cancer: Prognostic significance after 6 years' follow-up

1991 • 212 citations

Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases.

1987 • 205 citations

Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer.

1994 • 205 citations

Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma

1997 • 202 citations

Prognostic significance of bone marrow micrometastases in patients with gastric cancer.

1996 • 195 citations

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.

1991 • 178 citations

Local Recurrences Following Mastectomy: Support for the Concept of Tumor Dormancy

1994 • 178 citations

Immunocytological detection of bone marrow micrometastasis in operable non-small cell lung cancer.

1993 • 170 citations

Urokinase and plasminogen activator inhibitor type 1 in pulmonary adenocarcinoma

1994 • 169 citations

The Urokinase-type Plasminogen Activator Receptor Mediates Tyrosine Phosphorylation of Focal Adhesion Proteins and Activation of Mitogen-activated Protein Kinase in Cultured Endothelial Cells

1998 • 162 citations

The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptase-polymerase-chain reaction is related to the stage of disease

1996 • 160 citations

The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma.

1991 • 147 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

The Relationship Between Micrometastases in the Bone Marrow, Histopathologic Features of the Primary Tumor in Breast Cancer and Prognosis

1988 • 139 citations

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer

1994 • 134 citations

Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system.

1995 • 116 citations

Downstream targets of urokinase‐type plasminogen‐activator‐mediated signal transduction

1998 • 105 citations

Structural and Functional Analyses of Benzamidine-Based Inhibitors in Complex with Trypsin: Implications for the Inhibition of Factor Xa, tPA, and Urokinase

1998 • 104 citations

Recombinant soluble urokinase receptor as a scavenger for urokinase‐type plasminogen activator (uPA)

1994 • 101 citations

Immunocytochemical Detection of Disseminated Tumor Cells in the Bone Marrow of Patients With Esophageal Carcinoma

1996 • 99 citations

Primary tumor and metastasis in ovarian cancer differ in their content of urokinase-type plasminogen activator, its receptor, and inhibitors types 1 and 2.

1995 • 96 citations

Expression and localization of elements of the plasminogen activation system in benign breast disease and breast cancers

1993 • 92 citations

Immunocytochemical double staining of cytokeratin and prostate specific antigen in individual prostatic tumour cells

1993 • 91 citations

RT‐PCR‐Based Detection of Occult Disseminated Tumor Cells in Peripheral Blood and Bone Marrow of Patients with Solid Tumors: An Overview

2000 • 83 citations

Ficoll-isopaque gradients for the determination of density distributions of human blood lymphocytes and other reticulo-endothelial cells

1974 • 82 citations

Structure and function of the urokinase receptor

1993 • 80 citations

Detection and management of bone marrow micrometastases in breast cancer.

1994 • 75 citations

Transcriptional Induction of the Urokinase Receptor Gene by a Constitutively Active Src

1999 • 72 citations

Urokinase plasminogen activator receptor (uPA-R): one potential characteristic of metastatic phenotypes in minimal residual tumor disease.

1997 • 72 citations

Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.

1997 • 68 citations

Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach.

1993 • 59 citations

Structural requirements for glycosyl‐phosphatidylinositol‐anchor attachment in the cellular receptor for urokinase plasminogen activator

1992 • 58 citations

Disseminated Epithelial Tumor Cells in Bone Marrow of Patients with Esophageal Cancer: Detection and Prognostic Significance

1996 • 55 citations

Prognostic Relevance of MMP-2 (72-kD Collagenase IV) in Gastric Cancer

1998 • 55 citations

Strong prognostic impact of tumor-associated urokinase-type plasminogen activator in completely resected adenocarcinoma of the esophagus.

1998 • 55 citations

Targeted disruption of the K-Ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis

1999 • 53 citations

Transactivation of the Urokinase-type Plasminogen Activator Receptor Gene through a Novel Promoter Motif Bound with an Activator Protein-2α-related Factor

1999 • 41 citations

An immunohistochemical assessment of cathepsin D in gastric carcinoma

1997 • 39 citations

Minimal Residual Epithelial Cancer: Diagnostic Approaches and Prognostic Relevance

1996 • 39 citations

The prognostic impact of the urokinase-type plasminogen activator system is associated with tumour differentiation in gastric cancer

1996 • 30 citations

Increase of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) in plasma after thrombolytic therapy of patients with myocardial infarction. A randomised, placebo-controlled study

1992 • 29 citations

Regulation and Functional Role of MHC Expression on Tumors

1989 • 22 citations

Immunocytochemical Phenotyping of Disseminated Tumor Cells in Bone Marrow by uPA Receptor and CK18: Investigation of Sensitivity and Specificity of an Immunogold/Alkaline Phosphatase Double Staining Protocol

1997 • 19 citations