EIGHTH GADDUM MEMORIAL LECTURE UNIVERSITY OF LONDON INSTITUTE OF EDUCATION DECEMBER 1980: BIOLOGICAL IMPORTANCE OF PROSTACYCLIN

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Cholesterol in the Prediction of Atherosclerotic Disease

1979 • 1,333 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS

1979 • 1,012 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Prostaglandins: Their Disappearance from and Release into the Circulation

1967 • 898 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties

1979 • 786 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

1978 • 715 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

1977 • 683 citations

Advances in prostaglandin and thromboxane research

1980 • 675 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects

1980 • 642 citations

The release and fate of vaso‐active hormones in the circulation

1969 • 639 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

Effect of Heparin and Heparin Fractions on Platelet Aggregation

1980 • 607 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Advances in prostaglandin and thromboxane research

1976 • 602 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease

1981 • 597 citations

PLASMA LIPIDS AND LIPOPROTEINS IN GREENLANDIC WEST COAST ESKIMOS

1972 • 578 citations

PLATELET-MEMBRANE FATTY ACIDS, PLATELET AGGREGATION, AND THROMBOXANE FORMATION DURING A MACKEREL DIET

1980 • 551 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Choline esters in tissue extracts

1933 • 490 citations

THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD

1964 • 478 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Zur Kenntnis der pharmakologischen Wirkungen von Nativsekreten und Extrakten männlicher accessorischer Geschlechtsdrüsen

1934 • 403 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Prostacyclin is a circulating hormone

1978 • 380 citations

Generation of prostacyclin by lungs in vivo and its release into the arterial circulation

1978 • 374 citations

The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.

1978 • 364 citations

Effect on Blood Lipids and Haemostasis of a Supplement of Cod-Liver Oil, Rich in Eicosapentaenoic and Docosahexaenoic Acids, in Healthy Young Men

1981 • 359 citations

Localisation and stimulation of prostacyclin production in vascular cells

1978 • 356 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

1978 • 339 citations

Prostacyclin: A Potent Antimetastatic Agent

1981 • 335 citations

Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid

1979 • 318 citations

Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3′,5′-cyclic monophosphate and protein kinase

1977 • 311 citations

Recovery of Endothelial Cell Prostacyclin Production after Inhibition by Low Doses of Aspirin

1979 • 310 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.

1981 • 300 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

HqMOLYTIC-URqMIC SYNDROME: DEFICIENCY OF PLASMA FACTOR(S) REGULATING PROSTACYCLIN ACTIVITY?

1978 • 294 citations

DIFFERENTIAL INHIBITION OF PROSTACYCLIN PRODUCTION AND PLATELET AGGREGATION BY ASPIRIN

1979 • 284 citations

Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

1977 • 279 citations

SUCCESSFUL THERAPY OF ADVANCED ARTERIOSCLEROSIS OBLITERANS WITH PROSTACYCLIN

1979 • 279 citations

The chemical transmitter at synapses in a sympathetic ganglion

1934 • 279 citations

Inhibition of Prostacyclin and Platelet Thromboxane A₂after Low-Dose Aspirin

1981 • 278 citations

The estimation of adrenaline and allied substances in blood

1949 • 267 citations

Nitroglycerin Stimulates Synthesis of Prostacyclin by Cultured Human Endothelial Cells

1981 • 252 citations

Prevention of Thrombosis in Patients on Hemodialysis by Low-Dose Aspirin

1979 • 248 citations

Human Pulmonary Endothelial Cells in Culture

1980 • 233 citations

Leukotrienes and Slow Reacting Substance of Anaphylaxis (SRS‐A)

1980 • 228 citations

Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung

1974 • 226 citations

Thromboxane A₂in Vasotonic Angina Pectoris

1981 • 226 citations

Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function.

1980 • 225 citations

Dependency of Renal Blood Flow on Prostaglandin Synthesis in the Dog

1973 • 222 citations

Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias

1981 • 220 citations

The effect of dietary supplementation of fish oil on experimental myocardial infarction

1980 • 219 citations

Contribution of prostaglandins to the renal circulation in conscious, anesthetized, and laparotomized dogs.

1977 • 217 citations

Clinical pharmacology of prostacyclin

1981 • 211 citations

Cyclic adenosine 3′,5′-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets

1977 • 204 citations

Formation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release Reaction

1974 • 203 citations

Decreased vascular prostacyclin in experimental diabetes

1978 • 203 citations

Hemodialysis Using Prostacyclin Instead of Heparin as the Sole Antithrombotic Agent

1981 • 201 citations

DIFFERENTIAL INHIBITION BY LOW-DOSE ASPIRIN OF HUMAN VENOUS PROSTACYCLIN SYNTHESIS AND PLATELET THROMBOXANE SYNTHESIS

1981 • 200 citations

Chemical stability of prostacyclin (PGI2) in aqueous solutions

1978 • 197 citations

Inhibition of tumour growth in vivo and in vitro by prostaglandin E

1976 • 196 citations

Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells.

1978 • 196 citations

Slow Reacting Substances (SRSs): The structure identification of SRSs from rat basophil leukaemia (RBL-1) cells

1980 • 192 citations

Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets.

1977 • 191 citations

Thrombogenic Effect of High-Dose Aspirin in Rabbits

1978 • 191 citations

Conversion of prostaglandin endoperoxides to C₁₇‐hydroxy acids catalyzed by human platelet thromboxane synthase

1977 • 188 citations

Pharmacological control of prostaglandin and thromboxane release from macrophages

1978 • 187 citations

The Effect of Cod Liver Oil and Corn Oil on Platelets and Vessel Wall in Man

1981 • 186 citations

Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

1980 • 185 citations

Platelet and Blood Vessel Arachidonate Metabolism and Interactions

1979 • 181 citations

Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men

1978 • 181 citations

An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli-purification, identification and unique biological significance

1974 • 178 citations

Inhibition of polymorphonuclear leukocyte adherence by prostacyclin.

1980 • 177 citations

Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium

1979 • 176 citations

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition

1976 • 176 citations

Cardiac and Renal Prostaglandin I2

1978 • 174 citations

ADMINISTRATION TO MAN OF UK-37,248-01, A SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE

1981 • 168 citations

RECIRCULATION OF PROSTACYCLIN (PGI₂) IN THE DOG

1978 • 167 citations

Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells.

1981 • 166 citations

Effect of pyrogen and antipyretics on prostaglandin activity in cisternal c.s.f. of unanaesthetized cats

1973 • 166 citations

Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina

1979 • 164 citations

The action of prostaglandin synthetase on 2-arachidonyl-lecithin

1968 • 160 citations

Fatty Acids and Their Prostaglandin Derivatives: Inhibitors of Proliferation in Aortic Smooth Muscle Cells

1977 • 157 citations

Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa

1981 • 157 citations

The Origin of Atherosclerosis

1977 • 157 citations

Nomenclature for leukotrienes

1980 • 157 citations

Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium

1978 • 157 citations

Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin.

1981 • 155 citations

Effects of all CIS-5, 8,11,14,17 eicosapentaenoic acid and PGH3 on platelet aggregation

1979 • 154 citations

Cardiovascular pharmacology of the prostaglandins

1982 • 154 citations

Clinical pharmacology of platelets

1977 • 153 citations

Prostaglandin synthesis by bovine mesenteric arteries and veins.

1975 • 152 citations

Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.

1978 • 150 citations

Thromboxane A2 biosynthesis in the ureter obstructed isolated perfused kidney of the rabbit.

1978 • 146 citations

THROMBOXANE SYNTHETASE INHIBITION AS ANTITHROMBOTIC STRATEGY

1981 • 145 citations

Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets

1977 • 144 citations

Enhanced formation of PGI2, a potent hypotensive substance, by aortic rings and homogenates of the spontaneously hypertensive rat

1978 • 142 citations

Cyclic AMP inhibits synthesis of prostaglandin endoperoxide (PGG2) in human platelets

1976 • 142 citations

Heparin‐induced thrombocytopenia: Association with a platelet aggregating factor and arterial thromboses

1979 • 138 citations

Prevention of blockage of partially obstructed coronary arteries with prostacyclin correlates with inhibition of platelet aggregation

1979 • 135 citations

The protective effects of dietary fish oil on focal cerebral infarction

1979 • 135 citations

Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets.

1977 • 132 citations

Clinical pharmacology of platelets

1977 • 127 citations

Thromboxane Generation and Platelet Aggregation in Survivals of Myocardial Infarction

1978 • 125 citations

Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach

1976 • 124 citations

Release of vasodilator prostaglandin, PGI2, from isolated rat lung during vasoconstriction.

1981 • 124 citations

PROSTACYCLIN TO PREVENT PLATELET ACTIVATION DURING CHARCOAL HÆMOPERFUSION IN FULMINANT HEPATIC FAILURE

1980 • 123 citations

A double blind placebo controlled crossover study of prostacyclin in man

1979 • 121 citations

Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells

1982 • 120 citations

PROSTACYCLIN CAN REPLACE HEPARIN IN HÆMODIALYSIS IN DOGS

1978 • 120 citations

Evidence for distinct prostaglandin I2 and D2 receptors in human platelets.

1979 • 118 citations

Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery.

1980 • 117 citations

Generation of prostacyclin-like substance and lipid peroxidation in vitamin E-deficient rats

1980 • 115 citations

Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis

1976 • 114 citations

Inhibition of prostacyclin by treatment of endothelium with aspirin. Correlation with platelet adherence.

1979 • 114 citations

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs

1972 • 113 citations

Homeostasis of effector systems which can also be recruited for immunologic reactions.

1978 • 112 citations

Effects of intravenous infusion of prostacyclin (PGI2) in man

1980 • 111 citations

Vascular actinos of arachidonic acid and its metabolites in perfused mesenteric and femoral beds of the dog

1978 • 111 citations

Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate

1976 • 110 citations

Prostacyclin release and the modulation of some vasoactive hormones

1980 • 110 citations

Lipoproteins and the inhibitory effect of human endothelial cells on platelet function.

1978 • 110 citations

STIMULATION OF PROSTACYCLIN RELEASE FROM VESSEL WALL BY BAY g 6575, AN ANTITHROMBOTIC COMPOUND

1979 • 108 citations

Endoperoxides and thromboxanes structural determinants for platelet aggregation and vasoconstriction

1977 • 108 citations

PGI2 production by rat blood vessels: Diminished prostacyclin formation in veins compared to arteries

1978 • 106 citations

Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets

1977 • 106 citations

The effect of prostacyclin (PGT2) on platelet behaviour. Thrombus formation in vivo and bleeding time.

1979 • 105 citations

Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 cells is associated with platelet-derived growth-promoting activity.

1980 • 104 citations

Prostacyclin in experimental myocardial ischemia: Effects on hemodynamics, regional myocardial blood flow, infarct size and mortality

1981 • 103 citations

Pharmacology of platelet-affecting drugs.

1980 • 103 citations

Dihomo-γ-linolenate suppresses platelet aggregation when administered in vitro or in vivo

1974 • 102 citations

In vitro studies of thromboresistance: the role of prostacyclin (PGI2) in platelet adhesion to cultured normal and virally transformed human vascular endothelial cells.

1980 • 99 citations

PROSTACYCLIN: HAEMODYNAMIC AND METABOLIC EFFECTS IN PATIENTS WITH CORONARY ARTERY DISEASE

1981 • 98 citations

Myocardial infarction over a five-year period—I. Prevalence, incidence and mortality experience

1973 • 98 citations

Biosynthesis of Prostacyclin in Rat Cerebral Microvessels and the Choroid Plexus

1981 • 97 citations

Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta

1980 • 96 citations

Plasma High-Density Lipoproteins and Ischemic Heart Disease

1978 • 91 citations

PROSTACYCLIN: A SOLUTION TO SOME PROBLEMS OF EXTRACORPOREAL CIRCULATION

1979 • 89 citations

Is prostacyclin a physiologically important circulating anti-platelet agent?

1980 • 88 citations

The Effect of Prostacyclin (PGI2) on Platelet Behaviour. Thrombus Formation in Vivo and Bleeding Time

1979 • 84 citations

Release of histamine, kinin and prostaglandins during carrageenin-induced inflammation in the rat.

1969 • 83 citations

A new potential mediator of arterial thrombosis whose biosynthesis is inhibited by aspirin

1973 • 81 citations

The effect of prostacyclin infusion on endotoxin-induced lung injury.

1981 • 77 citations

Prostacyclin as a circulatory hormone

1979 • 76 citations

Treatment of pulmonary embolism with prostacyclin.

1980 • 75 citations

Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity

1980 • 75 citations

Metabolism of arachidonic acid in rabbit ocular tissues.

1979 • 74 citations

Preliminary Experience With Prostaglandins E1 and I2 in Peripheral Vascular Disease

1981 • 71 citations

Synthesis of prostaglandin 6-keto F1α by cultured aortic smooth muscle cells and stimulation of its formation in a coupled system with platelet lysates

1978 • 70 citations

Endothelial cell adenylate cyclase: Activation by catecholamines and prostaglandin I2

1980 • 70 citations

Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells

1980 • 70 citations

Transformation of arachidonic acid into thromboxane B2 by the homogenates of activated macrophages

1978 • 69 citations

Dietary manipulation of prostaglandin and thromboxane synthesis in heart, aorta and blood platelets of the rat.

1980 • 69 citations

Treatment of Intermittent Claudication

1963 • 68 citations

Acetylsalicylic acid, bleeding time and age

1980 • 68 citations

Age-related decrease in prostacyclin biosynthetic activity in rat aortic smooth muscle cells

1980 • 66 citations

Biosynthesis of thromboxanes in human platelets. I. Characterization and assay of thromboxane systhetase

1977 • 66 citations

Measurement of circulating prostacyclin

1981 • 64 citations

Prostacyclin produced by the pregnant uterus in the dog may act as a circulating vasodepressor substance.

1981 • 64 citations

PRODUCTION OF 6-OXO-PGF1α BY HUMAN LUNG IN VIVO

1979 • 62 citations

Effects of feeding ethyl-dihomo-γ-linolenate on prostaglandin biosynthesis and platelet aggregation in the rabbit

1976 • 62 citations

Effect of aspirin on prevention of coronary and cerebrovascular disease in patients with rheumatoid arthritis. A long-term follow-up study.

1978 • 61 citations

Salutary Effects of Prostacyclin in Endotoxic Shock

1980 • 61 citations

A plasma factor in uraemia which stimulates prostacyclin release from cultured endothelial cells

1980 • 60 citations

Evidence for the mechanism by which eicosapentaenoic acid inhibits human platelet aggregation and secretion - implications for the prevention of vascular disease

1979 • 60 citations

Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy

1978 • 60 citations

INTERNATIONAL REVIEW OF EXPERIMENTAL PATHOLOGY

1967 • 60 citations

The Mode of Action of Anti-inflammatory Drugs which Prevent the Peroxidation of Arachidonic Acid

1980 • 59 citations

Microemboli during cardiopulmonary bypass detected by ultrasound.

1969 • 58 citations

Decreased vascular prostacyclin (PGI2) in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compound bay g 6575

1980 • 58 citations

The ability of vascular tissue to produce prostacyclin decreases with age

1981 • 57 citations

Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man

1979 • 56 citations

The interaction of platelets with aortic subendothelium: inhibition of adhesion and secretion by prostaglandin I2

1981 • 56 citations

Intravenous Prostacyclin in Thrombotic Thrombocytopenic Purpura

1981 • 55 citations

Bioassay of prostaglandins and biologically active substances derived from arachidonic acid.

1978 • 54 citations

Biosynthesis of thromboxane B2: Assay, isolation, and properties of the enzyme system in human platelets

1976 • 54 citations

The effect of aspirin inhibition of PGI2 production on platelet adherence to normal and damaged rabbit aortae

1980 • 53 citations

Steroidal antiinflammatory drugs as inhibitors of phospholipase A2.

1978 • 53 citations

The effect of peroxidized arachidonic acid upon human platelet aggregation

1974 • 52 citations

In-vitro venous prostacyclin production, plasma 6-keto-prostaglandin F1 alpha concentrations, and diabetic retinopathy.

1981 • 52 citations

Stimulation of human foreskin fibroblast adenosine 3‘:5‘-cyclic monophosphate levels by prostacyclin (prostaglandin I2).

1979 • 51 citations

Blood platelets do not provide endoperoxides for vascular prostacyclin production

1979 • 50 citations

Prostacyclin in physiology and pathophysiology.

1982 • 49 citations

Heparin and dextran sulfate antagonize PGI2 inhibition of platelet aggregation

1979 • 49 citations

The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings].

1976 • 48 citations

Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries

1980 • 47 citations

Thromboxane A2 biosynthesis in human lung fibroblasts WI-38

1978 • 47 citations

The effect of arachidonic- and eicosapentaenoic acid on the synthesis of prostacyclin-like material in human umbilical vasculature.

1980 • 46 citations

Prostaglandins and cardiovascular disease

1981 • 46 citations

Prevention of infarction-induced decrease in circulating platelet count by prostacyclin

1980 • 43 citations

Platelet adhesion and mural platelet thrombus formation on aortic subendothelium of rats, rabbits, and guinea pigs correlate negatively with the vascular PGI2 production.

1981 • 43 citations

Diminished Urinary Prostacyclin Metabolite in Essential Hypertension

1980 • 42 citations

Binding and inactivation of prostacyclin (PGI₂) by human erythrocytes

1983 • 42 citations

Critical Appraisal of the Therapeutic Value of α-Tocopherol

1962 • 42 citations

Preparation and biochemical properties of PGH3

1979 • 42 citations

Prostacyclin and Thrombotic Microangiopathy

1980 • 42 citations

ANTI‐AGGREGATORY EFFECT OF PROSTACYCLIN (PGI₂) in vivo

1979 • 40 citations

Metabolism and action of the prostaglandin endoperoxide PGH2 in rat kidney

1977 • 40 citations

Changes in pigeon cone photocurrent caused by reduction in extracellular calcium activity.

1978 • 39 citations

Enhancement of platelet aggregation by tranylcypromine in mouse cerebral microvessels.

1978 • 39 citations

Heparin induced platelet aggregation: in vitro confirmation of thrombotic complications associated with heparin therapy.

1979 • 38 citations

Cyclic AMP in human blood platelets: relation to platelet prostaglandin synthesis induced by centrifugation or surface contact.

1976 • 38 citations

Short term suppression of hyperacute renal allograft rejection in presensitised dogs with prostacyclin

1980 • 36 citations

Maintenance of the tone of the human umbilical artery by prostaglandin and thromboxane formation.

1976 • 36 citations

Measurement of epinephrine, norepinephrine and related compounds; bioassay procedures.

1959 • 36 citations

An antiserum to 5,6-dihydro prostacyclin (PGI1) which also binds prostacyclin

1978 • 36 citations

OKY-1581, a potential selective thromboxane synthetase inhibitor

1981 • 36 citations

Release of prostacyclin into the bloodstream and its exhaustion in humans after local blood flow changes (ischemia and venous stasis)

1980 • 33 citations

Prostacycin production by arterialized autogenous venous grafts in dogs

1981 • 32 citations

Some properties of prostacyclin synthase from pig aorta

1979 • 29 citations

The treatment of peripheral occlusive arterial disease with alpha-tocopherol as compared with vasodilator agents and antiprothrombin (dicumarol).

1968 • 29 citations

Inhibition of PGI<sub>2</sub> (Prostacyclin) Synthesis in the Arterial Wall Enhances the Formation of White Platelet Thrombi <i>in vivo</i>

1978 • 26 citations

Uncontrolled PGI2 production by whole vessel wall segments due to thrombin generation and its prevention by heparin

1979 • 26 citations

Infarct size reduction by prostacyclin after coronary occlusion in conscious dogs

1979 • 26 citations

Unstable metabolites of arachidonic acid aspirin and the formation of the haemostatic plug

1978 • 26 citations

Disappearance of prostacyclin (PGI2) in the circulation of the dog [proceedings].

1978 • 26 citations

Biochemical properties of the prostaglandin/thromboxane synthetase of human blood platelets and comparison with the synthetase of bovine seminal vesicles

1976 • 25 citations

Interactions between stimulated platelets and endothelial cells in vitro

1981 • 24 citations

Activation of guinea pig pulmonary adenylate cyclase by prostacyclin

1980 • 23 citations

Effect of in vitro aging on 6-ketoprostaglandin F1α -producing activity in cultured human diploid lung fibroblasts

1979 • 23 citations

Circulating Prostacyclin Concentrations May Be Increased by Bendrofluazide in Patients with Essential Hypertension

1980 • 22 citations

Prostacyclin is produced in whole blood [proceedings].

1978 • 22 citations

Prostaglandins in shock: to give or to block?

1980 • 22 citations

Rationale and Proposal for Use of Prostacyclin in Thrombotic Thrombocytopenic Purpura Therapy

1981 • 20 citations

PLATELETS AND THE VESSEL WALL: HOW MUCH ASPIRIN?

1980 • 20 citations

An Observation of Thromboxane A<sub>2</sub> in Arterial Blood after Cholesterol Feeding in Rabbits

1978 • 19 citations

Antigenic Relationship Between Blood Platelets and Vascular Endothelium

1969 • 18 citations

Angiotensin-induced release of prostacyclin (PGI2) into circulation of anaesthetized cats

1979 • 17 citations

ASPIRIN AND MYOCARDIAL INFARCTION

1972 • 17 citations

Platelet protein synthesis studied in a cell-free system

1970 • 16 citations

Inhibition of platelet activation by prostacyclin: Possible consequences in coagulation and anticoagulation

1981 • 15 citations

STIMULATION BY ANGIOTENSIN OF PROSTACYCLIN BIOSYNTHESIS IN RATS AND DOGS

1980 • 14 citations

Prostacyclin (PGI2) inhibits the formation of platelet thrombi induced by adenosine diphosphate (ADP) in vivo [proceedings].

1977 • 14 citations

PROSTACYCLIN AND ATHEROSCLEROSIS

1981 • 14 citations

The action of cyclooxygenase and prostacyclin-synthetase inhibitors on platelet-vessel wall interaction.

1980 • 13 citations

The effect of PGI2 and PGI2 analogies with increased stability on platelet cAMP content and aggregation

1980 • 12 citations

The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts

1972 • 12 citations

Effects of some naturally occurring prostaglandins of the D-, E-, and I-type and synthetic analogues on adenylate cyclase of human fat cell ghosts

1979 • 11 citations

Clinics in Rheumatic Diseases

1981 • 11 citations

Biological Activities of Some Metabolites and Analogues of Prostacyclin

1981 • 11 citations

Prostacyclin reduces the number of 'slow moving' leucocytes in hamster cheek pouch venules [proceedings].

1978 • 10 citations

The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits.

1975 • 8 citations

Prostacyclin production by rabbit aorta, pericardium, pleura, peritoneum and dura mater.

1978 • 7 citations

Treatment of Fulminant Hepatic Failure

1971 • 6 citations

Platelet-endothelial prostaglandin biochemical imbalance in sudden infant death syndrome in the newborn: Capillary endothelial cell deficiency and/or lag in maturation of prostacyclin synthetase

1978 • 6 citations

The release of thromboxane B2 by rabbit peritoneal polymorphonuclear leucocytes [proceedings].

1978 • 3 citations