DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

Inhibition of platelet prostaglandin synthetase by oral aspirin.

1978 • 552 citations

The effect of salicylates on the hemostatic properties of platelets in man

1968 • 544 citations

Platelet and Fibrinogen Consumption in Man

1972 • 492 citations

The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3′:5′-cyclic monophosphate in platelets

1971 • 422 citations

Studies of Platelet and Fibrinogen Kinetics in Patients with Prosthetic Heart Valves

1970 • 334 citations

Inhibition of prostaglandin synthesis in man

1972 • 276 citations

EFFECT OF DIPYRIDAMOLE ON HUMAN PLATELET BEHAVIOUR

1965 • 244 citations

Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin

1977 • 209 citations

Clinical pharmacology of platelets

1977 • 153 citations

Effect of a Pyrimidopyrimidine Derivative on Thrombus Formation in the Rabbit

1965 • 132 citations

Clinical pharmacology of platelets

1977 • 127 citations

Effect of dipyridamole and aspirin in thrombotic microangiopathy.

1972 • 58 citations

An antiserum to 5,6-dihydro prostacyclin (PGI1) which also binds prostacyclin

1978 • 36 citations