Heparin and dextran sulfate antagonize PGI2 inhibition of platelet aggregation

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

1977 • 625 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

SUCCESSFUL THERAPY OF ADVANCED ARTERIOSCLEROSIS OBLITERANS WITH PROSTACYCLIN

1979 • 279 citations

Binding of heparin on the surface of cultured human endothelial cells

1978 • 236 citations

Cyclic AMP and Platelet Function

1972 • 213 citations

Heparin induced thrombocytopenia with thrombotic and hemorrhagic manifestations.

1973 • 206 citations

Selective Binding Site for [3H]Prostacyclin on Platelets

1979 • 199 citations

Identification of platelet receptors for prostaglandin I2 and D2.

1979 • 191 citations

Platelet function testing.

1978 • 154 citations

Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets

1977 • 144 citations

On the Mechanism of Platelet Aggregation Induced by Heparin, Protamine and Polybrene

1972 • 135 citations

The Potentiation of Platelet Aggregation and Adhesion by Heparin in Vitro and in Vivo

1973 • 134 citations

Disseminated Intravascular Coagulation During Heparin Therapy

1974 • 125 citations

PROSTACYCLIN CAN REPLACE HEPARIN IN HÆMODIALYSIS IN DOGS

1978 • 120 citations

Heparin-Induced Thrombocytopenia

1969 • 111 citations

Platelet Aggregation Following Heparin and Protamine Administration

1978 • 79 citations

Anti-platelet action of intravenous infusion of prostacyclin in man

1978 • 76 citations

Cyclic Nucleotides in Platelet Function

1978 • 68 citations

Modulation of adenylate cyclase activity by sulfated glycosaminoglycans I. Inhibition by heparin of gonadotropin- stimulated ovarian adenylate cyclase

1978 • 57 citations

Morphine antagonises prostaglandin E1- mediated inhibition of human platelet aggregation

1975 • 38 citations

The interaction of platelets with a tritium-labelled heparin

1976 • 34 citations

Modulation of adenylate cyclase activity by sulfated glycosaminoglycans II. Effects of mucopolysaccharides and dextran sulfate on the activity of adenylate cyclase derived from various tissues

1978 • 31 citations

Thrombocytopenia Occurring during Heparin Therapy

1976 • 31 citations

Heparin inhibits PGE1-sensitive adenylate cyclase and antagonizes PGE1 antiaggregating effect in human platelets.

1979 • 29 citations

The effects of dextran sulfate, heparin and PGE1 on adenylate cyclase activity and aggregation of human platelets

1979 • 26 citations

Heparin: A potent inhibitor of ovarian luteinizing hormone‐sensitive adenylate cyclase

1977 • 26 citations

Effect of platelet activity of inhibition of adenylate cyclase

1978 • 21 citations

Heparin-induced coagulopathy.

1977 • 17 citations