A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Factors influencing platelet function: adhesion, release, and aggregation.

1970 • 635 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

1974 • 517 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

Lipid composition of subcellular particles of human blood platelets

1969 • 337 citations

Selective inhibition by mepacrine of the release of “rabbit aorta contracting substance” evoked by the administration of bradykinin

1972 • 249 citations

Prostaglandin D2 inhibits the aggregation of human platelets

1974 • 230 citations

Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung

1976 • 192 citations

Relationship between chemical structure and plateletaggregation activity of prostaglandins

1969 • 178 citations

An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli-purification, identification and unique biological significance

1974 • 178 citations

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition

1976 • 176 citations

Stimulation of human platelet adenylate cyclase by prostaglandin D2

1974 • 170 citations

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

1971 • 163 citations

Increased Lysosomal Enzymes in Muscular Dystrophy of Vitamin E-deficient Rabbits

1962 • 151 citations

EFFECT OF ANTI-INFLAMMATORY AGENTS ON PLATELETS

1968 • 148 citations

Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach

1976 • 124 citations

Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate

1976 • 110 citations

Free Radical Theory of Aging: Free Radical Reactions in Serum

1966 • 62 citations

The vascular wall in the pathogenesis of thrombosis.

1966 • 60 citations

Polyhydroxy cyclic ethers formed from tritiated arachidonic acid by acetone powders of sheep seminal vesicles

1971 • 43 citations

Platelet adhesion in the rabbit abdominal aorta following the removal of the endothelium: a scanning and transmission electron microscopical study

1971 • 41 citations

Prostaglandins and platelet function.

1976 • 35 citations

Effects of Intravenous Phospholipid Containing Phosphatidyl Serine on Blood Clotting with Particular Reference to the Russell's Viper Venom Time

1962 • 22 citations

Transformation of prostaglandin G2 into 6(9)-oxy-11,15-dihydroxy-prosta-7,13-dienoic acid by the rat stomach fundus

1976 • 16 citations

Effect of a Natural Phosphatidyl Serine Fraction on Blood Coagulation, Platelet Aggregation and Haemostasis

1969 • 10 citations

Inhibition of platelet aggregation and white thrombus formation by prostaglandin analogue ONO-747.

1976 • 2 citations