DIFFERENTIAL INHIBITION OF PROSTACYCLIN PRODUCTION AND PLATELET AGGREGATION BY ASPIRIN

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

Inhibition of platelet prostaglandin synthetase by oral aspirin.

1978 • 552 citations

THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD

1964 • 478 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin

1977 • 209 citations

Studies on lipid peroxides in platelets. I. Method of assay and effect of storage.

1970 • 88 citations

A laminar flow superfusion technique with much increased sensitivity for the detection of smooth muscle-stimulating substances

1976 • 78 citations

Platelet function studies in human beings receiving 300 mg. of aspirin per day.

1970 • 62 citations

Comparative evaluation of the inhibitory effects of aspirin-like drugs on prostaglandin production by human platelets and synovial tissue.

1976 • 27 citations

Bioassay by cascade superfusion using a highly sensitive laminar flow technique

1977 • 25 citations