Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Mitochondria and Apoptosis

1998 • 8,909 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Apoptosis Signaling

2000 • 1,290 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Two Distinct Pathways Leading to Nuclear Apoptosis

2000 • 737 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

1999 • 354 citations

Apoptosomes: engines for caspase activation

2002 • 306 citations

Adult Apaf-1-Deficient Mice Exhibit Male Infertility

2000 • 202 citations

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

2002 • 193 citations

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

2002 • 188 citations

The role of ARK in stress-induced apoptosis in Drosophila cells

2002 • 162 citations

Apoptotic Protease Activating Factor 1 (Apaf-1)–Independent Cell Death Suppression by Bcl-2

2000 • 159 citations

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

2000 • 142 citations

The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes

2002 • 48 citations

Irreversible Caspase Inhibitors: Tools for Studying Apoptosis

1999 • 46 citations

Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.

2001 • 40 citations