Angiopoietin-1 Requires p190 RhoGAP to Protect against Vascular Leakage in Vivo

Rho GTPases in cell biology

2002 • 4,662 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Rho and Rac Take Center Stage

2004 • 1,797 citations

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

1999 • 1,702 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion

2000 • 1,167 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

2006 • 864 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

1999 • 659 citations

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

2002 • 561 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions

2000 • 496 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

2006 • 490 citations

Novel Role of gp91 ^phox -Containing NAD(P)H Oxidase in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis

2002 • 464 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Rho GTPases and the regulation of endothelial permeability

2002 • 457 citations

RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity

2001 • 431 citations

Cadherin Engagement Regulates Rho family GTPases

2001 • 421 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression

2001 • 354 citations

Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death

2006 • 322 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Phosphoinositide 3‐kinase‐dependent activation of Rac

2003 • 318 citations

Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering

1999 • 269 citations

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

2006 • 247 citations

VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam

2002 • 241 citations

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

2005 • 211 citations

Protective Role of Angiopoietin-1 in Endotoxic Shock

2004 • 195 citations

Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction

2000 • 172 citations

Angiopoietin-1 Opposes VEGF-Induced Increase in Endothelial Permeability by Inhibiting TRPC1-Dependent Ca ² Influx

2005 • 164 citations

Suppression of RhoA Activity by Focal Adhesion Kinase-induced Activation of p190RhoGAP

2005 • 161 citations

Angiopoietin‐1 inhibits endothelial permeability, neutrophil adherence and IL‐8 production

2003 • 154 citations

Cyclic AMP Blocks Bacterial Lipopolysaccharide-Induced Myosin Light Chain Phosphorylation in Endothelial Cells Through Inhibition of Rho/Rho Kinase Signaling

2000 • 146 citations

Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis

2004 • 142 citations

Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation

2005 • 131 citations

Cdc42 Regulates Adherens Junction Stability and Endothelial Permeability by Inducing α-Catenin Interaction With the Vascular Endothelial Cadherin Complex

2005 • 85 citations

Rho GTPases and leucocyte-induced endothelial remodelling

2005 • 78 citations

Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury

2006 • 76 citations

Calcium dependence of the thrombin-induced increase in endothelial albumin permeability

1989 • 72 citations

Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1

2004 • 62 citations

Propagation of electromagnetic waves of crossroads with a reflector inside a tunnel

1989 • 36 citations

Tyrosine phosphorylation and the small GTPase rac cross-talk in regulation of endothelial barrier function

2005 • 31 citations