Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

2001 • 8,356 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

ROCKs: multifunctional kinases in cell behaviour

2003 • 1,866 citations

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

2004 • 1,186 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

Epidemiology of sepsis: An update

2001 • 823 citations

Long-Term Inhibition of Rho-Kinase Suppresses Angiotensin II–Induced Cardiovascular Hypertrophy in Rats In Vivo

2003 • 427 citations

Long-Term Treatment With a Rho-Kinase Inhibitor Improves Monocrotaline-Induced Fatal Pulmonary Hypertension in Rats

2003 • 401 citations

Cold‐induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species

1999 • 321 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Regulation of innate immunity by Rho GTPases

2005 • 294 citations

Clinical Gram-positive sepsis

1999 • 257 citations

Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism

1991 • 237 citations

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury

2004 • 223 citations

Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells

2000 • 210 citations

Anti-Fas Induces Hepatic Chemokines and Promotes Inflammation by an NF-κB-independent, Caspase-3-dependent Pathway

2001 • 205 citations

Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas-antibody-induced liver injury

1998 • 176 citations

Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells

2000 • 171 citations

Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury

1997 • 162 citations

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

2001 • 157 citations

Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury

1993 • 128 citations

Attenuation of Endotoxin-Induced Acute Lung Injury by the Rho-Associated Kinase Inhibitor, Y-27632

2005 • 115 citations

Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression

2005 • 113 citations

Apoptosis in sepsis

2000 • 111 citations

Lipopolysaccharide and<scp>d</scp>-galactosamine-induced hepatic injury is mediated by TNF-α and not by Fas ligand

2000 • 108 citations

Critical role of CXC chemokines in endotoxemic liver injury in mice

2003 • 104 citations

Hepatocyte Injury During Post-Operative Sepsis: Activated Neutrophils as Potential Mediators

1988 • 83 citations

Important Role of P-Selectin for Leukocyte Recruitment, Hepatocellular Injury, and Apoptosis in Endotoxemic Mice

2004 • 68 citations

IL-1 Receptor-Associated Kinase and Low Molecular Weight GTPase RhoA Signal Molecules Are Required for Bacterial Lipopolysaccharide-Induced Cytokine Gene Transcription

2002 • 63 citations

Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion

2002 • 54 citations

Lymphocyte function antigen‐1 mediates leukocyte adhesion and subsequent liver damage in endotoxemic mice

2004 • 50 citations

Involvement of Rho-Kinase in Cold Ischemia-Reperfusion Injury after Liver Transplantation in Rats

2004 • 40 citations

p38 Mitogen-Activated Protein Kinase-Dependent Chemokine Production, Leukocyte Recruitment, and Hepatocellular Apoptosis in Endotoxemic Liver Injury

2005 • 39 citations