Biochemical basis of alcoholism: Statements and hypotheses of present research

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Frontiers in Catecholamine Research

1973 • 1,252 citations

Psychopharmacology: A Generation of Progress

1979 • 1,101 citations

Alcohol Problems in Adoptees Raised Apart From Alcoholic Biological Parents

1973 • 895 citations

Hepatic Microsomal Ethanol-oxidizing System

1970 • 824 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

Induction of physical dependence upon ethanol and the associated behavioral changes in rats

1975 • 740 citations

Catecholamines: Basic and Clinical Frontiers

1979 • 730 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

1968 • 562 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

High Blood Acetaldehyde Levels after Ethanol Administration

1975 • 514 citations

Drinking Problems in Adopted and Nonadopted Sons of Alcoholics

1974 • 514 citations

Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of Ethanol

1977 • 511 citations

Adaptation of membrane lipids to alcohols

1976 • 483 citations

Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes.

1977 • 458 citations

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

1970 • 441 citations

Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal Reaction

1971 • 437 citations

Alcohol tolerance and dependence

1980 • 419 citations

Biphasic action of ethanol

1977 • 373 citations

Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors

1976 • 350 citations

Behavioral Neurochemistry: Neuroregulators and Behavioral States

1978 • 333 citations

Relationship of alcohol dose to intensity of withdrawal signs in mice.

1972 • 329 citations

Metabolic Effects of Ethanol in Perfused Rat Liver

1969 • 327 citations

Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo

1973 • 312 citations

Interaction of Mixed‐Function Oxidation with Biosynthetic Processes

1973 • 305 citations

The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo.

1972 • 290 citations

Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary

1980 • 267 citations

Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats

1971 • 263 citations

Racial differences in alcohol sensitivity: A new hypothesis

1979 • 259 citations

ANIMAL MODELS IN ALCOHOL RESEARCH

1979 • 255 citations

Biological Effects of Alcohol

1980 • 254 citations

Neuropeptides and neural transmission

1980 • 252 citations

The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver

1972 • 250 citations

THE ROLE OF ACETALDEHYDE IN THE ACTIONS OF ETHANOL

1975 • 250 citations

ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS

1974 • 247 citations

Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing Enzymes

1968 • 247 citations

Activation of hypothalamic β-endorphin pools by reward induced by highly palatable food

1983 • 245 citations

Biological Basis of Alcoholism

1972 • 241 citations

Criteria for an animal model of alcoholism

1973 • 238 citations

Biochemical factors in alcoholism

1967 • 233 citations

ALTERATIONS IN THE TURNOVER OF BRAIN NOREPINEPHRINE AND DOPAMINE IN ALCOHOL‐DEPENDENT RATS

1974 • 231 citations

Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference

1973 • 229 citations

Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.

1976 • 228 citations

Recent Advances in Studies of Alcoholism

1973 • 227 citations

Ethanol Ingestion: Differences in Blood Acetaldehyde Concentrations in Relatives of Alcoholics and Controls

1979 • 225 citations

Biological aspects of alcohol

1971 • 223 citations

Handbook of Drug and Chemical Stimulation of the Brain

1976 • 222 citations

Effects of chronic ethanol treatment on mitochondrial functions damage to coupling site I

1974 • 215 citations

Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.

1973 • 213 citations

Inhibition of drug metabolism by acute ethanol intoxication

1970 • 211 citations

A review of methods to induce alcohol addiction in animals

1973 • 210 citations

EFFECTS OF CHRONIC INTAKE OF ETHANOL ON RATE OF ETHANOL METABOLISM

1966 • 210 citations

Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

1974 • 203 citations

Brain Aldehyde Dehydrogenase

1966 • 201 citations

The characteristics of the ‘peroxidatic’ reaction of catalase in ethanol oxidation

1973 • 195 citations

Functional Compartmentation of Acetaldehyde Oxidation in Rat Liver

1974 • 193 citations

The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man.

1967 • 192 citations

Progress toward a voluntary oral consumption model of alcoholism

1979 • 190 citations

Effects of ethanol on central and peripheral noradrenergic neurons.

1974 • 188 citations

Metabolic alterations produced in the liver by chronic ethanol administration. Increased oxidative capacity

1973 • 187 citations

Biology of Opioid Peptides

1979 • 185 citations

Alcohol Drinking: Abnormal Intake Caused by Tetrahydropapaveroline in Brain

1977 • 183 citations

Monoamine oxidase inhibition in brain and liver produced by β-carbolines: structure-activity relationships and substrate specificity

1977 • 180 citations

Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration

1970 • 178 citations

The route and significance of endogenous synthesis of alkaloids in animals

1982 • 177 citations

Psychopharmacology of alcohol

1980 • 170 citations

Synaptosomal membrane lipids of mice during continuous exposure to ethanol

1977 • 169 citations

Brain acetaldehyde after ethanol administration

1976 • 169 citations

Central Deficiency of β-Endorphin in Alcohol Addicts*

1982 • 168 citations

The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis

1980 • 163 citations

Metabolic alterations produced in the liver by chronic ethanol administration. Changes related to energetic parameters of the cell

1973 • 162 citations

Effects of ethanol on Na, K, Mg-stimulated microsomal atpase activity

1965 • 161 citations

The distribution and metabolism of acetaldehyde in rats during ethanol oxidation—I

1977 • 159 citations

Dopamine-Related Tetrahydroisoquinolines: Significant Urinary Excretion by Alcoholics After Alcohol Consumption

1979 • 157 citations

Peptides: Integrators of Cell and Tissue Function

1981 • 156 citations

Psychopharmacology of Alcohol

1978 • 152 citations

The Determinants of Alcohol Preference in Animals

1972 • 152 citations

Purification and Characterization of a Reduced Nicotinamide Adenine Dinucleotide Phosphate-linked Aldehyde Reductase from Brain

1970 • 151 citations

Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin

1968 • 150 citations

Platelet and Plasma Amine Oxidase Activity in Alcoholic Individuals

1978 • 150 citations

Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication

1975 • 149 citations

Effect of ethanol on the amount and enzyme activities of hepatic rough and smooth microsomal membranes

1973 • 149 citations

Acquisition and loss of tolerance to ethanol by the rat.

1969 • 148 citations

Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary

1983 • 146 citations

The effect of acetaldehyde on mitochondrial function

1974 • 145 citations

Aldehyde Dehydrogenase and Ethanol Preference in Mice

1970 • 145 citations

Effect of hypnotics on mice genetically selected for sensitivity to ethanol

1976 • 145 citations

BRAIN LEVELS AND TURNOVER RATES OF PRESUMPTIVE NEUROTRANSMITTERS AS INFLUENCED BY ADMINISTRATION AND WITHDRAWAL OF ETHANOL IN MICE¹

1974 • 143 citations

THE GAMMA‐AMINOBUTYRIC ACID (GABA) SYSTEM IN BRAIN DURING ACUTE AND CHRONIC ETHANOL INTOXICATION

1975 • 141 citations

Biogenic Amine-Aldehyde Condensation Products: Tetrahydroisoquinolines and Tryptolines (szlig-Carbolines)

1980 • 140 citations

Acetaldehyde Oxidation by Hepatic Mitochondria: Decrease After Chronic Ethanol Consumption

1975 • 139 citations

Chronic Central Nervous System Toxicity of Alcohol

1973 • 138 citations

Hepatic microsomal ethanol-oxidizing system: Solubilization, isolation, and characterization

1974 • 138 citations

Effect of ethanol on the metabolism of brain catecholamines

1973 • 137 citations

Hepatic microsomal alcohol-oxidizing system. Affinity for methanol, ethanol, propanol, and butanol.

1975 • 136 citations

Inhibition of aldehyde dehydrogenase in brain and liver by cyanamide

1976 • 135 citations

Adrenal Function and Alcoholism

1971 • 135 citations

Effect of ethanol administration on hepatic ethanol and drug-metabolizing enzymes and on rates of ethanol degradation.

1971 • 135 citations

Neurobiological mechanisms of adaptation and behavior

1975 • 133 citations

Ethanol-induced alterations of norepinephrine metabolism in man.

1967 • 131 citations

BRAIN CONCENTRATIONS OF BIOGENIC AMINE METABOLITES IN ACUTELY TREATED AND ETHANOL‐DEPENDENT RATS

1976 • 131 citations

Naloxone-induced inhibition of ethanol dependence in mice

1977 • 130 citations

Effects of lower alcohols on potassium transport and microsomal adenosine-triphosphatase activity of rat cerebral cortex

1966 • 127 citations

Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats

1979 • 127 citations

Heterogeneity of NADPH-Dependent Aldehyde Reductase from Human and Rat Brain

1973 • 127 citations

Is Alcoholism Hereditary?

1971 • 125 citations

Changes in cation transport and (Na + K)-activated adenosine triphosphatase produced by chronic administration of ethanol.

1970 • 125 citations

Localization and characteristics of rat liver mitochondrial aldehyde dehydrogenases

1976 • 125 citations

Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles

1976 • 125 citations

Brain and pituitary peptides

1980 • 125 citations

The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol.

1977 • 125 citations

Tetrahydroisoquinoline alkaloids: uptake by rat brain homogenates and inhibition of catecholamine uptake.

1971 • 125 citations

Blood Concentrations of Acetaldehyde and Ethanol in Chronic Alcoholics

1970 • 123 citations

Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver

1972 • 122 citations

Differential actions on voluntary alcohol intake of tetrahydroisoquinolines or a β-carboline infused chronically in the ventricle of the rat

1977 • 122 citations

1-Methyl-?-carboline (Harmane), a potent endogenous inhibitor of benzodiazepine receptor binding

1980 • 119 citations

Microsomal ethanol-oxidizing system (MEOS): Purification and properties of a rat liver system free of catalase and alcohol dehydrogenase

1972 • 119 citations

Biochemical Pharmacology of Ethanol

1975 • 118 citations

Hypothesis: energy wastage in alcoholism and drug abuse: possible role of hepatic microsomal enzymes

1976 • 118 citations

Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats

1976 • 117 citations

ENZYMES CATALYSING ETHANOL METABOLISM IN NEURAL AND SOMATIC TISSUES OF THE RAT

1972 • 117 citations

Tetrahydropapaveroline : Formation and in rat brain

1974 • 117 citations

Salsolinol, an Alkaloid Derivative of Dopamine formed in vitro during Alcohol Metabolism

1970 • 116 citations

The Metabolism of Alcohol

1976 • 116 citations

Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro.

1970 • 115 citations

Metabolic Aspects of Alcoholism

1976 • 115 citations

Characteristics of acetaldehyde oxidation in rat liver mitochondria.

1976 • 114 citations

Effects of ethanol and pentobarbital on release of acetylcholine from cerebral cortex slices.

1967 • 114 citations

Alcoholism, Alcohol, and Drugs

1971 • 113 citations

Development of functional dependence on ethanol in dopaminergic systems.

1979 • 113 citations

Metabolism of Ethanol

1992 • 113 citations

Aldehyde adducts in alcoholism

1986 • 112 citations

Morphine-induced Suppression of Voluntary Alcohol Drinking in Rats

1973 • 112 citations

CHANGES IN MONOAMINE CONCENTRATIONS IN MOUSE BRAIN ASSOCIATED WITH ETHANOL DEPENDENCE AND WITHDRAWAL

1974 • 112 citations

Neurobiology of tetrahydro-β-carbolines

1980 • 111 citations

Alkaloid products in the metabolism of alcohol and biogenic amines

1976 • 111 citations

ALCOHOL DEHYDROGENASE ACTIVITY IN RAT BRAIN AND LIVER

1970 • 107 citations

The dopamine-releasing actions of neuroleptics and ethanol.

1974 • 107 citations

In vivo acetaldehyde in the brain of the rat treated with ethanol

1980 • 107 citations

Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain.

1975 • 106 citations

Suppression by dopamine-agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis

1974 • 105 citations

Microsomal Ethanol Oxidizing System (MEOS): Current Status of Its Characterization and Its Role

1977 • 105 citations

Reduced Nicotinamide-adenine Dinucleotide Phosphate Oxidase: Activity Enhanced by Ethanol Consumption

1970 • 103 citations

Inhibition of brain microsomal adenosine triphosphatases by general depressants

1967 • 103 citations

Ethanol dependence in the rat: A parametric analysis

1975 • 101 citations

Oxidation of Acetaldehyde by Rat‐Liver Mitochondria in Relation to Ethanol Oxidation and the Transport of Reducing Equivalents across the Mitochondrial Membrane

1973 • 101 citations

Neuropharmacological actions of enkephalin after systemic administration

1976 • 99 citations

The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450

1978 • 98 citations

Preference for alcohol evoked by tetrahydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat

1977 • 98 citations

Effect of ethanol concentration on rates of ethanol elimination in normal and alcohol-treated rats in vivo

1979 • 97 citations

Genetic Influence upon Phenobarbital-induced Increase in Rat Liver Supernatant Aldehyde Dehydrogenase Activity

1972 • 96 citations

Formation of 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline under physiological conditions

1961 • 96 citations

Inherited Differences in Intensity of Alcohol Withdrawal Reactions in Mice

1973 • 95 citations

Comparison of the effects of biogenic amines on cyclic GMP and cyclic AMP levels in mouse cerebellumin vitro

1975 • 95 citations

Alcohol drinking in the rat induced by acute intracerebral infusion of two tetrahydroisoquinolines and a β-carboline

1977 • 95 citations

Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preference

1975 • 95 citations

An investigation of the mechanisms of action of 5-hydroxytryptamine in the suppression of ethanol intake

1982 • 94 citations

Hepatic microsomal ethanol oxidizing system (MEOS): Differentiation from alcohol dehydrogenase and NADPH oxidase

1970 • 92 citations

Alterations in opiate receptor function after chronic ethanol exposure.

1982 • 92 citations

Effect of acute and chronic administration of ethanol on the 5-hydroxytryptamine turnover and tryptophan hydroxylase activity of the mouse brain

1971 • 92 citations

Tetrahydronorharmane (Tetrahydro-?-carboline), a physiologically occurring compound of indole metabolism

1978 • 92 citations

Metabolic Derangement Induced by Alcohol

1967 • 91 citations

Acute tolerance in inbred and selected lines of mice

1979 • 91 citations

Alterations in Phospholipid Composition in Ethanol Tolerance and Dependence

1979 • 90 citations

Hepatic ethanol metabolism: Respective roles of alcohol dehydrogenase, the microsomal ethanol-oxidizing system, and catalase

1976 • 89 citations

Excretion of tetrahydroharmane and harmane into the urine of man and rat after a load with ethanol

1980 • 89 citations

Reduction of striatal dopamine release during an ethanol withdrawal syndrome

1977 • 89 citations

Chronic ethanol feeding produces an increase in muscarinic cholinergic receptors in mouse brain

1979 • 89 citations

Ethanol oxidation in the microsomal fraction of rat liver

1969 • 88 citations

The effects of long-chain alcohols on membrane lipids and the (Na+ + K+)-ATPase

1973 • 88 citations

Blood methanol concentrations during experimentally induced ethanol intoxication in alcoholics.

1971 • 88 citations

Persistence of a “subacute withdrawal syndrome” following chronic ethanol intake

1979 • 86 citations

Naloxone alters alcohol drinking induced in the rat by tetrahydropapaveroline (THP) infused ICV

1982 • 86 citations

EFFECTS OF ETHANOL ON SEROTONIN METABOLISM IN BRAIN

1974 • 85 citations

Ethanol preference in the rat: interactions between brain serotonin and ethanol, acetaldehyde, paraldehyde, 5-HTPand 5-HTOL

1972 • 83 citations

Brain Alcohol Dehydrogenase

1968 • 83 citations

Dissociation of alcohol tolerance and dependence

1976 • 83 citations

Alterations in dopamine receptor sensitivity by chronic ethanol treatment

1977 • 82 citations

Comparative Aspects of Tolerance to, and Dependence on, Alcohol, Barbiturates and Opiates

1977 • 82 citations

Alcohol Tolerance in a Cholinergic Nerve Terminal: Relation to the Membrane Expansion-Fluidization Theory of Ethanol Action

1977 • 82 citations

Alcoholism: Progress in research and treatment

1974 • 81 citations

Tetrahydroisoquinolines in the Brain: The Basis of an Animal Model of Alcoholism

1978 • 81 citations

Neuroamine Condensations in Human Subjects

1980 • 81 citations

Biochemical and Clinical Aspects of Alcohol Metabolism

1970 • 80 citations

Hepatic redox state: Attentuation of the acute effects of ethanol induced by chronic ethanol consumption

1974 • 80 citations

Pathways responsible for the adaptive increase in ethanol utilization following chronic treatment with ethanol: inhibitor studies with the hemoglobin-free perfused rat liver.

1976 • 79 citations

Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo

1975 • 79 citations

INHIBITION OF THE TRANSPORT OF 5‐HYDROXYINDOLEACETIC ACID FROM BRAIN BY ETHANOL¹

1975 • 79 citations

ALCOHOL AND OPIATES: A REVIEW OF COMMON NEUROCHEMICAL AND BEHAVIORAL MECHANISMS

1977 • 79 citations

The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens

1976 • 78 citations

Benzodiazepines modulate striatal enkephalin levels via a gabaergic mechanism

1980 • 78 citations

A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence

1974 • 77 citations

Molecular injury to mitochondria produced by ethanol and acetaldehyde.

1975 • 76 citations

Ethanol binding to hepatic microsomes—its increase by ethanol consumption

1971 • 76 citations

Intraventricular self-administration of acetaldehyde and voluntary consumption of ethanol in rats

1980 • 75 citations

Noradrenergic sensitivity of the cerebral cortex after chronic ethanol ingestion and withdrawal.

1975 • 75 citations

Effects of acute and chronic ethanol on the γ-aminobutyric acid system in rat brain

1973 • 74 citations

Induction of hepatic microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent production of hydrogen peroxide by chronic prior treatment with ethanol.

1973 • 74 citations

Brain (Na+ + K+)-activated adenosine triphosphatase activity and neurotransmitter uptake in alcohol-dependent rats

1973 • 72 citations

Alcohol metabolizing enzymes: Studies of isozymes in human biopsies and cultured fibroblasts

1979 • 72 citations

Essays in neurochemistry and neuropharmacology

1977 • 72 citations

Cross-tolerance between ethanol and morphine with respect to their hypothermic effects

1979 • 72 citations

Ethanol Oxidation by a Component of Liver Microsomes Rich in Cytochrome P-450

1973 • 71 citations

Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone

1983 • 71 citations

Dopamine receptor function after chronic ingestion of ethanol

1978 • 70 citations

Dissociation between physical dependence and volitional ethanol consumption: Role of multiple withdrawal episodes

1974 • 69 citations

The Effects of Aliphatic Alcohols on the Biophysical and Biochemical Correlates of Membrane Function

1975 • 69 citations

Chromosomal damage in chronic alcohol users

1975 • 69 citations

Mutagenic activity of aldehydes

1979 • 69 citations

Inhibition by β-carbolines of monoamine uptake into a synaptosomal preparation: Structure-activity relationships

1977 • 69 citations

The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats

1977 • 69 citations

K+-evoked release of met-enkephalin from rat striatum in vitro: Effect of putative neurotransmitters and morphine

1980 • 69 citations

6,7-Dihydroxytetrahydroisoquinoline: Uptake and Storage by Peripheral Sympathetic Nerve of the Rat

1972 • 68 citations

5-Hydroxytryptamine and 5-hydroxyindolylacetic acid content in brain of rat strains selected for their alcohol intake

1972 • 68 citations

Acute and chronic ethanol ingestion and serotonin metabolism in rat brain.

1978 • 67 citations

NADPH-dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes

1974 • 67 citations

Increased Salsolinol Levels in Rat Striatum and Limbic Forebrain Following Chronic Ethanol Treatment

1982 • 67 citations

Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro.

1970 • 67 citations

Potency in Male Rhesus Monkeys: Effects of Continuously Receptive Females

1978 • 67 citations

7 Alcohol and neurotransmitters

1978 • 67 citations

XIX. Enzyme expansion theory of drug tolerance and physical dependence.

1968 • 67 citations

Involvement of neurohypophyseal peptides in drug-mediated adaptive responses

1980 • 66 citations

Noradrenergic mediation of the positive reinforcing properties of ethanol: I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition.

1977 • 66 citations

SELECTIVE ACTION OF ALCOHOLS ON CEREBRAL CALCIUM LEVELS

1976 • 66 citations

THE EFFECTS OF AGE AND ALCOHOL ON (Na⁺+ K⁺)‐ATPASE ACTIVITY OF WHOLE HOMOGENATE AND SYNAPTOSOMES PREPARED FROM MOUSE AND HUMAN BRAIN

1975 • 66 citations

Effect of ethanol administration on cyclic 3',5'-adenosine monophosphate metabolism in brain

1973 • 65 citations

Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. II. Behavioral measures.

1977 • 65 citations

Noradrenergic involvement in the acute effects of ethanol.

1975 • 64 citations

Effect of chronic ethanol treatment on metabolism of drugs in vitro and in vivo

1976 • 64 citations

Potentiation of ethanol withdrawal by prior dependence

1979 • 64 citations

Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol Administration

1978 • 63 citations

Effects of long-term ethanol treatment on aldehyde and alcohol dehydrogenase activities in rat liver

1975 • 63 citations

Voluntary Alcohol Consumption in Animals: Peripheral and Intracerebral Factors

1966 • 63 citations

Hormonal influences in the development of the hypermetabolic state of the liver produced by chronic administration of ethanol.

1975 • 63 citations

Addiction and Brain Damage

1981 • 63 citations

The effect of ethanol on drug oxidations in vitro and the significance of ethanol–cytochrome P-450 interaction

1973 • 63 citations

Research Advances in Alcohol and Drug Problems

1978 • 63 citations

The role of calcium in the central effects of biogenic amines

1974 • 63 citations

Isoquinoline alkaloids

1978 • 62 citations

Pharmacological aspects of physical dependence on ethanol

1976 • 62 citations

Structure-action relationship of β-carbolines as monoamine oxidase inhibitors

1966 • 62 citations

Involvement of biogenic amine metabolism in ethanol addiction.

1975 • 62 citations

Turnover rates and steady-state levels of brain serotonin in alcohol-dependent rats

1974 • 62 citations

Accelerated development of tolerance during repeated cycles of ethanol exposure

1978 • 61 citations

Protective effect of cysteine on the inhibition of mitochondrial functions by acetaldehyde

1976 • 61 citations

Studies on metabolic tolerance to alcohol, hepatomegaly and alcoholic liver disease

1979 • 61 citations

Toxic effects of ethanol: Possible role of acetaldehyde, tetrahydroisoquinolines, and tetrahydro-β-carbolines

1975 • 60 citations

Duration of the enhanced activity of the microsomal ethanol-oxidizing enzyme system and rate of ethanol degradation in ethanol-fed rats after withdrawal

1972 • 60 citations

Morphine and Ethanol Physical Dependence: A Critique of a Hypothesis

1970 • 60 citations

ALTERATIONS IN RECEPTORS CONTROLLING DOPAMINE SYNTHESIS AFTER CHRONIC ETHANOL INGESTION

1978 • 60 citations

Effects of acute and chronic ethanol administration and withdrawal on adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate levels in the rat brain.

1977 • 60 citations

The Metabolism of Alcohol in Normals and Alcoholics: Enzymes

1971 • 59 citations

Non-enzymatic Ethanol Oxidation in Biological Extracts.

1973 • 59 citations

Alterations in Neurotransmitter Function after Acute and Chronic Treatment with Ethanol

1979 • 59 citations

Putative Role of Isoquinoline Alkaloids in Alcoholism: A Link to Opiates

1978 • 59 citations

Tetrahydroisoquinoline alkaloids: stimulated secretion from the adrenal medulla.

1973 • 59 citations

Opiate receptor binding and analgesic effects of the tetrahydroisoquinolines salsolinol and tetrahydropapaveroline.

1980 • 58 citations

TETRAHYDRO‐β‐CARBOLINES: SPECIFIC INHIBITORS OF TYPE A MONOAMINE OXIDASE IN RAT BRAIN¹

1977 • 58 citations

Influence of Prolonged Ethanol Intake on the Levels and Turnover of Alcohol and Aldehyde Dehydrogenases and Glutathione

1980 • 58 citations

Opioid peptides (endorphins) in pituitary and brain

1977 • 57 citations

A possible neurochemical mechanism for brain and nerve damage associated with chronic alcoholism

1982 • 57 citations

The swift increase in alcohol metabolism

1982 • 56 citations

Concentration Dependence of Ethanol Metabolism In Vivo in Rats and Man

1978 • 56 citations

Possible involvement of acetaldehyde, norepinephrine and their tetrahydroisoquinoline derivatives in the regulation of ethanol self-administration

1977 • 56 citations

Effect of Ethanol and Acetaldehyde on Liver and Brain Monoamine Oxidase

1964 • 56 citations

β‐CARBOLINES: A TOOL FOR INVESTIGATING STRUCTURE‐ACTIVITY RELATIONSHIPS OF THE HIGH‐AFFINITY UPTAKE OF SEROTONIN, NORADRENALINE, DOPAMINE, GABA AND CHOLINE INTO A SYNAPTOSOME‐RICH FRACTION OF VARIOUS REGIONS FROM RAT BRAIN¹

1978 • 55 citations

Identification of an Isoquinoline Alkaloid after Chronic Exposure to Ethanol

1978 • 55 citations

Tetrahydroisoquinoline alkaloids in the adrenal medulla after perfusion with “blood concentrations” of [14C]acetaldehyde

1971 • 55 citations

Age and strain differences in the rate of development of functional tolerance to ethanol by mice

1979 • 55 citations

Tetrahydroisoquinoline alkaloids: Uptake and release by adrenergic nerves in vivo

1974 • 54 citations

The metabolism of acetaldehyde by the brain in vivo

1963 • 54 citations

Brain Noradrenergic Systems as a Prerequisite for Developing Tolerance to Barbiturates

1978 • 54 citations

Enhanced activity of the beta-endorphinergic system in the anterior and neurointermediate lobe of the rat pituitary after chronic treatment with ethanol liquid diet.

1984 • 53 citations

Quantitation of pathways of ethanol metabolism

1977 • 52 citations

Changes in activity and hormonal sensitivity of brain adenyl cyclase following chronic ethanol administration

1972 • 52 citations

The Influence of Prolonged Ethanol Intake on the Levels and Turnover of Alcohol and Aldehyde Dehydrogenases and of Brain (Na + K)‐ATPase of Rats

1978 • 52 citations

Nerve cell calcium as a messenger for opiate and endorphin actions.

1979 • 51 citations

Activation energy and phospholipid requirements of membrane-bound adenosine triphosphatases

1973 • 51 citations

Alcohol withdrawal reactions in mouse strains selectively bred for long or short sleep times

1975 • 51 citations

Effect of acute and chronic ethanol administration on serotonin turnover in rat brain

1974 • 51 citations

Effects of serotonin depletion on the volitional alcohol intake of rats during a condition of psychological stress

1969 • 51 citations

Effect of ethanol on the uptake by rat brain synaptosomes of {3H}DL-norepinephrine, {3H}5-hydroxytryptamine, {3H}GABA and {3H}glutamate

1973 • 50 citations

The Effect of Ethanol Concentration on Ethanol Oxidation Rate in Rat Liver Slices.

1971 • 49 citations

Modification of glycoprotein residues as Ca2+ receptor sites after chronic ethanol exposure

1977 • 49 citations

Chronopharmacokinetics of ethanol

1976 • 49 citations

Differences in hepatic and metabolic changes after acute and chronic alcohol consumption.

1975 • 49 citations

Genetic influences on the rate of development of ethanol tolerance and the ethanol physical withdrawal syndrome in mice

1979 • 48 citations

Inhibition of monoamine uptake in synaptosomes by tetrahydroharmane and tetrahydroisoquinoline compounds

1973 • 48 citations

Alterations in volitional alcohol intake produced in rats by chronic intraventricular infusions of acetaldehyde, paraldehyde or methanol.

1969 • 48 citations

INTERACTIONS OF NARCOTICS, NARCOTIC ANTAGONISTS, AND ETHANOL DURING ACUTE, CHRONIC, AND WITHDRAWAL STATES

1976 • 47 citations

Ethanol-Induced Release of Acetaldehyde from Blood and its Effect on the Determination of Acetaldehyde

1970 • 47 citations

The effect of chronic ethanol treatment on behaviour and central monoamines in the rat

1977 • 47 citations

Effect of chronic intake of ethanol on pentobarbital metabolism.

1970 • 47 citations

An inborn alcohol tolerance in alcohol-preferring rats. The lack of relationship between tolerance to ethanol and the brain microsomal (Na+K+) ATPase activity

1977 • 47 citations

6-Hydroxy-tetrahydronorharmane (6-hydroxy-tetrahydro-?-carboline), a new active metabolite of indole-alkylamines in man and rat

1979 • 47 citations

Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake

1978 • 47 citations

Calcium Reversal of Nerve Blockade by Alcohols, Anesthetics, Tranquilizers, and Barbiturates

1974 • 47 citations

Alcoholism or Acetaldehydism?

1975 • 46 citations

Enzymatic Pathways of Ethanol Metabolism

1979 • 46 citations

METABOLIC CONSEQUENCES OF ETHANOL OXIDATION IN BRAINS FROM MICE CHRONICALLY FED ETHANOL

1973 • 46 citations

Neuroamine-derived alkaloids: Substrate-preferred inhibitors of rat brain monoamine oxidase in vitro

1976 • 46 citations

Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures.

1976 • 46 citations

Ethanol—A direct inducer of drug metabolism

1976 • 46 citations

The rapid development of functional tolerance to ethanol by mice

1979 • 46 citations

Metabolic Changes Induced by Alcohol

1971 • 46 citations

Rates of alcohol dehydrogenase-dependent ethanol metabolism in periportal and pericentral regions of the perfused rat liver.

1982 • 45 citations

Tetrahydro‐β‐carbolines and Corresponding Tryptamines: In Vitro Inhibition of Serotonin, Dopamine and Noradrenaline Uptake in Rat Brain Synaptosomes

1980 • 45 citations

Effect of drug administration on the activity of the hepatic microsomal ethanol oxidizing system

1970 • 45 citations

Suppression of ethanol withdrawal by dopamine

1976 • 45 citations

Effects of tetrahydro-β-carbolines on monoamine oxidase and serotonin uptake in mouse brain

1976 • 45 citations

Analysis of illicit diamorphine preparations by high-pressure liquid chromatography

1975 • 45 citations

Effect of ethanol on metabolism and subcellular distribution of serotonin in rat brain

1971 • 45 citations

The induction of ethanol dependence and the ethanol withdrawal syndrome: the effects of pyrazole

1974 • 44 citations

Brain and liver aldehyde dehydrogenase: Relations to ethanol consumption in wistar rats

1977 • 44 citations

Enhancement of Alcohol Withdrawal Convulsions in Mice by Haloperidol

1976 • 44 citations

Acetaldehyde occurrence in cerebrospinal fluid during ethanol oxidation in rats and its dependence on the blood level and on dietary factors

1977 • 44 citations

Acetaldehyde Metabolism In Vivo During Ethanol Oxidation

1977 • 44 citations

Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility.

1979 • 43 citations

Significance in vivo of the increase in micro-somal ethanol-oxidizing system after chronic administration of ethanol, pheno-barbital and chlorcyclizine

1972 • 43 citations

Effect of acute ethanol or acetaldehyde adminstration on the uptake, release, metabolism and turnover rate of norepinephrine in rat brain

1977 • 42 citations

Influence of Thyroid Function on the Acetaldehyde Level of Blood and Liver of Intact Rats during Ethanol Metabolism

1969 • 41 citations

Central neurons are depressed by iontophoretic and micropressure application of ethanol and tetrahydropapaveroline

1979 • 41 citations

Brain monoamine oxidase activity after chronic ethanol treatment of rats

1977 • 41 citations

Comparison of aldehyde dehydrogenases from cytosol and mitochondria of rat liver

1973 • 41 citations

Effects of Ethanol on Lipid, Uric Acid, Intermediary, and Drug Metabolism, Including the Pathogenesis of the Alcoholic Fatty Liver

1971 • 40 citations

Genetics and ethanol tolerance

1979 • 40 citations

Effect of chronic administration of ethanol on (Na + K)‐activated ATPase activity in six areas of the cat brain

1972 • 40 citations

Alcohol drinking induced in the monkey by Tetrahydropapaveroline (THP) infused into the cerebral ventricle

1982 • 39 citations

Diazepam-induced release of opioid activity in the rat brain

1980 • 39 citations

Heterogeneity of alcohol dehydrogenase enzymes in various tissues

1972 • 39 citations

Role of hormones in the mechanism of the swift increase in alcohol metabolism in the rat

1980 • 39 citations

Neurochemical Aspects of Tolerance to and Dependence on Ethanol

1973 • 38 citations

Hepatic microsomal ethanol-oxidizing system (MEOS): dissociation from reduced nicotinamide adenine dinucleotide phosphate oxidase and possible role of form I of cytochrome P-450.

1975 • 38 citations

The β-Carbolines (Harmanes) - A New Class of Endogenous Compounds:

1981 • 38 citations

Inhibition of catecholamine uptake and retention in synaptosomal preparations by tetrahydroisoquinoline and tetrahydroprotoberberine alkaloids

1975 • 38 citations

SELECTIVE BREEDING OF RATS FOR DIFFERENCES IN REACTIVITY TO ALCOHOL: AN APPROACH TO AN ANIMAL MODEL OF ALCOHOLISM

1977 • 38 citations

Chromosomal Damage by Alcohol In Vitro and In Vivo

1977 • 38 citations

Identification of catecholamine-derived alkaloids in mammals by gas chromatography and mass spectrometry

1974 • 38 citations

2,4-dinitrophenol-induced increase in ethanol and acetaldehyde oxidation in the perfused rat liver

1974 • 37 citations

Lack of alteration in regional brain adenosine-3′, 5′-cyclic monophosphate levels after acute and chronic treatment with ethanol

1976 • 37 citations

Acetaldehyde mediation in the mechanism of ethanol-induced changes in norepinephrine metabolism.

1970 • 36 citations

The effect of ethanol concentration upon in vivo metabolite levels of rat liver

1972 • 36 citations

Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.

1966 • 36 citations

Metabolism of aldehydes in brain.

1977 • 36 citations

CHANGES IN BRAIN ALCOHOL DEHYDROGENASE ACTIVITY DURING CHRONIC ETHANOL INGESTION AND WITHDRAWAL

1974 • 36 citations

Metabolic Aspects of Alcoholism in the Brain

1977 • 35 citations

Interaction of catecholamines with acetaldehyde to form tetrahydroisoquinoline neurotransmitters.

1979 • 35 citations

Biochemical aspects of alcoholism

1976 • 35 citations

Inhibition of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from bovine brain by barbiturates.

1971 • 35 citations

Salsolinol differentially affects mice selected for sensitivity to alcohol

1976 • 35 citations

Effects of ethanol on mouse brain (Na+K)-activated adenosine triphosphatase.

1972 • 35 citations

ALCOHOL METABOLISM OF INBRED STRAINS OF RATS WITH ALCOHOL PREFERENCE AND NONPREFERENCE

1977 • 34 citations

Factors Contributing to the Adaptive Increase in Ethanol Metabolism due to Chronic Consumption of Ethanol

1977 • 34 citations

Ethanol-induced Adaptation of Alcohol Dehydrogenase Activity in Rat Brain

1972 • 34 citations

Neurochemical correlates of ethanol withdrawal: alterations in serotoninergic function

1977 • 33 citations

Acute and chronic ethanol-induced alterations in brain norepinephrine metabolites in the rat

1976 • 33 citations

Metabolism of ethanol by rat liver microsomal enzymes

1970 • 33 citations

Acetaldehyde levels during ethanol oxidation: A diet-induced change and its relation to liver aldehyde dehydrogenases and redox states

1975 • 33 citations

Effect of 5,7-dihydroxytryptamine on the development of tolerance to ethanol

1980 • 33 citations

New pathway of ethanol metabolism in the liver.

1970 • 33 citations

EFFECTS OF ETHANOL ON NOREPINEPHRINE UPTAKE AND ELECTRICALLY STIMULATED RELEASE IN BRAIN TISSUE*

1973 • 33 citations

Dopamine release within forebrain sites perfused with tetrahydroisoquinolines or tryptoline in the rat

1978 • 33 citations

Ethanol-Induced Alteration in Membrane Phospholipid Composition: Possible Relationship to Development of Cellular Tolerance to Ethanol

1980 • 32 citations

Metabolic Correlates of Ethanol, Acetaldehyde, Acetate and Methanol in Humans and Animals

1975 • 32 citations

Low Acetaldehyde Levels in Blood, Breath and Cerebrospinal Fluid of Intoxicated Humans as Assayed by Improved Methods

1980 • 32 citations

Multiple metabolite theory, alcohol drinking and the alcogene.

1985 • 32 citations

The significance and characterization of hepatic microsomal ethanol oxidation in the liver.

1973 • 32 citations

Ethanol-Induced Changes in Body Temperature and Their Neurochemical Consequences

1979 • 32 citations

Alteration of Endogenous Catecholamine Metabolism by Ethanol Ingestion.

1967 • 32 citations

Inhibition of binding of aldehydes of biogenic amines in tissues

1973 • 32 citations

Significant pathways of hepatic ethanol metabolism.

1975 • 31 citations

Effect of p-chlorophenylalanine on the loss and maintenance of tolerance to ethanol

1978 • 31 citations

Tetrahydro‐β‐carbolines and Corresponding Tryptamines: In Vitro Inhibition of Serotonin and Dopamine Uptake by Human Blood Platelets

1980 • 31 citations

Catecholamine receptors and cyclic and formation in the central nervous system: Effects of tetrahydroisoquinoline derivatives

1978 • 31 citations

Effect of Withdrawal from Chronic Ethanol Ingestion on the cAMP Response of Cerebral Cortical Slices Using the Agonists Histamine, Serotonin, and Other Neurotransmitters

1975 • 31 citations

NEUROAMINE‐DERIVED ALKALOIDS: A POSSIBLE COMMON DENOMINATOR IN ALCOHOLISM AND RELATED DRUG DEPENDENCIES

1973 • 31 citations

POSSIBLE ROLE OF TETRAHYDROISOQUINOLINE ALKALOIDS IN POSTALCOHOL INTOXICATION STATES*

1976 • 30 citations

Neurohypophyseal peptide influences on ethanol tolerance and acute effects of ethanol

1980 • 30 citations

BIOGENESIS OF BIOLOGICALLY ACTIVE ALKALOIDS FROM AMINES BY ALCOHOL AND ACETALDEHYDE

1973 • 30 citations

Ethanol Alters Kinetic Characteristics and Function of Striatal Morphine Receptors

1981 • 30 citations

The adaptive increase in ethanol metabolism due to pretreatment with ethanol: A rapid phenomenon

1979 • 30 citations

Effects of ethanol on serotonergic neurons in the rat brain.

1974 • 29 citations

The Effects of Ethanol on Developing Catecholamine Neurons

1980 • 29 citations

The role of hydrogen peroxide and catalase in hepatic microsomal ethanol oxidation.

1973 • 29 citations

The Role of Acetaldehyde in the Actions of Ethanol

1971 • 29 citations

Activation of Ethanol Utilization in Perfused Liver from Normal and Ethanol-Pretreated Rats. The Effect of Hydrogen Peroxide Generating Substrates

1974 • 29 citations

Experimental Ethanol Ingestion: Sleep Variables and Metabolites of Dopamine and Serotonin in the Cerebrospinal Fluid

1975 • 29 citations

Effect of Chronic Alcohol Consumption on Ethanol and Acetaldehyde Metabolism

1975 • 29 citations

Stereoselective enzymatic O-methylation of tetrahydropapaveroline and tetrahydroxyberbine alkaloids

1979 • 29 citations

New Pathway of Ethanol Metabolism in the Liver

1970 • 28 citations

Biotransformation of 1-benzyl-1,2,3,4-tetrahydro-2-methylisoquinolines into tetrahydroprotoberberines with rat liver enzymes

1976 • 28 citations

EFFECT OF SALSOLINOL ON RAT BRAIN AND LIVER MONOAMINE OXIDASE

1971 • 28 citations

6,7‐Dihydroxytetrahydroisoquinoline: evidence for in vivo inhibition of intraneuronal monoamine oxidase

1975 • 28 citations

Effects of desglycinamide(9)-lysine(8)-vasopressin and prolyl-leucyl-glycinamide on oral ethanol intake in the rat

1979 • 28 citations

Biological Models of Alcohol Tolerance and Physical Dependence

1973 • 28 citations

Potentiation of ethanol narcosis by dopamine-andl-DOPA-based isoquinolines

1976 • 27 citations

The influence of arginine vasopressin and oxytocin on ethanol dependence and tolerance.

1979 • 27 citations

Effects of aldehydes on sodium plus potassium ion-stimulated adenosine triphosphatase of mouse brain

1975 • 27 citations

NEUROCHEMICAL ASPECTS OF ETHANOL DEPENDENCE**This work was supported by U.S. Public Health Service Grants NS-12759 and AA-2696 and a Campus Research Board Grant from the University of Illinois. B.T. is a Schweppe Foundation Fellow.

1977 • 27 citations

Work in progress on alcoholism

1976 • 27 citations

Acute tolerance to ethanol on the release of acetylcholine from the cat cerebral cortex

1978 • 27 citations

ETHANOL‐INDUCED ALTERATIONS OF DOPAMINE METABOLISM IN RAT LIVER*

1976 • 27 citations

Metabolism of ethanol and acetaldehyde by the isolated perfused rat brain.

1975 • 27 citations

Acetaldehyde Metabolism

1979 • 27 citations

Effect of Modification of Brain Serotonin (5‐HT) on Ethanol Tolerance

1979 • 27 citations

Relationship between alcohol preference and biogenic aldehyde metabolizing enzymes in rats

1977 • 27 citations

Barbiturate abuse and addiction and their relationship to alcohol and alcoholism.

1971 • 27 citations

EFFECTS OF CATECHOLAMINE SYNTHESIS INHIBITION ON ETHANOL‐INDUCED WITHDRAWAL SYMPTOMS IN MICE

1974 • 27 citations

Aldehyde Derivatives of Indoleamines and the Enhancement of their Binding onto Brain Macromolecules by Pentobarbital and Acetaldehyde

1972 • 27 citations

The effect of chronic ethanol administration on the levels of catecholamines in different regions of the rat brain.

1973 • 27 citations

Inhibition of sodium, potassium, and magnesium activated ATPases by acetaldehyde and "biogenic" aldehydes.

1974 • 26 citations

Alteration of central catecholamine metabolism following acute administration of ethanol

1978 • 26 citations

A FURTHER INSIGHT INTO THE METABOLISM OF CERTAIN βCARBOLINES

1973 • 26 citations

Ethanol-Induced Changes in Cation-Stimulated Adenosine Triphospha-Tase Activity and Lipid-Proteolipid Labeling of Brain Microsomes

1975 • 26 citations

Characterization of brain acetaldehyde oxidizing systems in the mouse

1979 • 26 citations

Interactions of Ethanol with Cyclic AMP

1975 • 26 citations

Inhibition of 5-hydroxytryptamine uptake by tetrahydronorharmane in vivo

1978 • 26 citations

A Role for Tetrahydroisoquinoline Alkaloids as False Adrenergic Neurotransmitters in Alcoholism

1973 • 26 citations

Changes in the Activity of Na+,K+-ATPase during Acute and Chronic Administration of Ethanol

1979 • 26 citations

Catalase involvement in microsomal ethanol-oxidizing system

1972 • 25 citations

ALCOHOL‐MEMBRANE INTERACTION IN THE BRAIN. I. REVERSIBILITY*

1976 • 25 citations

Detection of endogenous salsolinol in neonatal rat tissue by a radioenzymatic—thin-layer chromatographic assay

1979 • 25 citations

Brain aldehyde dehydrogenase: Adaptive increase following prolonged ethanol administration in rats

1978 • 25 citations

Ethanol and Acetaldehyde Effects on Metabolism and Binding of Biogenic Amines

1974 • 25 citations

Electron Paramagnetic Resonance Studies of Ethanol on Membrane Fluidity

1977 • 25 citations

Alcohol and Aldehyde Metabolism in Brain

1975 • 25 citations

Hepatic microsomal alcohol-oxidizing system in normal and acatalasemic mice: its dissociation from the peroxidatic activity of catalase-H2O2.

1975 • 25 citations

Use of genetic to test the potential role of serotonin in alcohol preference

1975 • 25 citations

Behavioral effects of salsolinol and ethanol on mice selected for sensitivity to alcohol-induced sleep time

1977 • 24 citations

Anesthesia. LII. Effects of Alcohols and Acetaldehyde on Oxidative Phosphorylation in Brain

1956 • 24 citations

Alcohol Euphoria: Possible Mediation via Endorphinergic Mechanisms

1979 • 24 citations

Preference for ethanol in the rhesus monkey following chronic infusion of ethanol into the cerebral ventricles

1972 • 24 citations

Biochemical and Biophysical Approaches in the Study of Ethanol-Membrane Interaction

1979 • 24 citations

Metabolism of ethanol and acetaldehyde by the isolated perfused rat brain

1975 • 23 citations

Effects of initial tolerance on acquired tolerance to alcohol in two selectively bred rat strains

1977 • 23 citations

Enhancement of ethanol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors

1976 • 23 citations

Alteration of ethanol effects by opiate antagonists.

1979 • 23 citations

An acetaldehyde artifact in studies of the interaction of ethanol with biogenic amine systems: the oxidation of ethanol by ascorbic acid

1977 • 23 citations

OPIATE-ETHANOL INTERACTION STUDIES

1977 • 23 citations

The effects of substrates of mixed function oxidase on ethanol oxidation in rat liver microsomes

1974 • 23 citations

Increase in hepatic NAD level ‐ its effect on the redox state and on ethanol and acetaldehyde metabolism

1974 • 23 citations

Hepatotoxicity of Acetaldehyde

1980 • 23 citations

Functional tolerance to ethanol in mice: relationship to lipid metabolism

1979 • 22 citations

Physical dependence on ethanol: Its relation to tolerance

1979 • 22 citations

Effect of p-chlorophenylalanine on development of cross-tolerance between pentobarbital and ethanol

1977 • 22 citations

Adrenergic nerve degeneration induced by condensation products of adrenaline and acetaldehyde

1977 • 22 citations

Pathways of Ethanol Metabolism in Perfused Rat Liver

1975 • 22 citations

Tetrahydroisoquinolines and the catecholamine-binding granules of the adrenal medulla

1972 • 22 citations

Effects of length of exposure to and concentration of acetaldehyde on the release of catecholamines

1974 • 21 citations

Effects of Ethanol on the Intermediary Metabolism of Liver and Brain

1979 • 21 citations

Ethanol-induced conformational changes in rat brain microsomal membranes

1977 • 21 citations

PHARMACOGENETICS OF ALCOHOLISM

1977 • 21 citations

Alcohol, Aldehydes and Biogenic Amines

1975 • 21 citations

Anesthesia. LIII. Effects of alcohols and acetaldehyde on oxidative phosphorylation in brain.

1956 • 21 citations

Effect of p-chlorophenylalanine on the acquisition of tolerance to the hypnotic effects of pentobarbital, barbital, and ethanol

1980 • 21 citations

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines

1980 • 21 citations

Control of Ethanol Oxidation and Its Interaction with Other Metabolic Systems

1979 • 21 citations

Effects of 6-hydroxydopamine or 5,7-dihydroxy-tryptamine on the development of physical dependence on ethanol

1977 • 20 citations

The polymorphisms of alcohol and aldehyde dehydrogenase and their significance for acetaldehyde toxicity

1983 • 20 citations

Ethanol inhibition of transport of 5-hydroxyindoleacetic acid from cerebrospinal fluid

1975 • 20 citations

Comparison of Ethanol Withdrawal Syndrome in Humans and Rats

1977 • 20 citations

INFLUENCE OF ETHANOL ON HUMAN CATECHOLAMINE METABOLISM

1976 • 20 citations

Comparison of acute and chronic ethanol administration on rates of ethanol elmination in the rat in vivo

1979 • 20 citations

Oxidation of ethanol by hepatic microsomes of acatalasemic mice

1974 • 20 citations

TETRAHYDROISOQUINOLINE ALKALOIDS: UPTAKE, STORAGE, AND SECRETION BY THE ADRENAL MEDULLA AND BY ADRENERGIC NERVES*

1973 • 20 citations

BRAIN SEROTONIN TURNOVER IN ALCOHOLIC MICE

1974 • 20 citations

Brain and blood levels of ethanol and acetaldehyde in strains of mice with different preferences for ethanol.

1975 • 20 citations

Relationship between 3,4‐Dihydroxyphenylacetaldehyde Levels and Tetrahydropapaveroline Formation

1978 • 20 citations

The Uptake of 6‐Methoxy‐1,2,3,4‐Tetrahydro‐β‐carboline and its Effect on 5‐Hydroxytryptamine Uptake and Release in Blood Platelets

1978 • 19 citations

Acetaldehyde: A Positive Reinforcer Mediating Ethanol Consumption

1980 • 19 citations

Effect of depletion of brain catecholamines on ethanol tolerance and dependence

1979 • 19 citations

Effects of Ethanol on Electrolyte Metabolism and Neurotransmitter Release in the CNS

1975 • 19 citations

Receptor‐Mediated Dopaminergic Function After Ethanol Withdrawal

1980 • 19 citations

Disposition of Catecholamine-Derived Alkaloids in Mammalian Systems

1975 • 19 citations

Alteration of norepinephrine metabolism by barbiturates

1974 • 19 citations

Adaptation to ethanol-induced fluidization of brain lipid bilayers

1979 • 19 citations

Effects of Ethanol on Brain Metabolism

1975 • 18 citations

Ethanol Metabolism in Vivo and the Role of Hepatic Microsomal Ethanol Oxidation

1972 • 18 citations

Effect of Ethanol and Ethanol Withdrawal on ³H‐Muscimol Binding and Behaviour in the Rat: A Pilot Study

1981 • 18 citations

Effects of Tetrahydropapaveroline on Dopamine and 5-Hydroxytryptamine Metabolism in Rat Brain <i>in vivo</i>

1976 • 18 citations

IN VIVO METABOLISM OF ETHANOL AT HIGH AND LOW CONCENTRATIONS

1977 • 17 citations

Role of calcium in ethanol-membrane interactions: A model for tolerance and dependence

1979 • 17 citations

Synergy of Ethanol and Alcohol-Like Metabolites: Tryptophol and 3,4-Dihydroxyphenylethanol

1973 • 17 citations

Changes in Receptor Sensitivity of the Cerebral Cortex and Liver During Chronic Ethanol Ingestion and Withdrawal

1977 • 17 citations

Examination of the Role of Tetrahydroisoquinoline Alkaloids in The Mediation of Ethanol Consumption in Rats

1980 • 17 citations

ALCOHOL, ALDEHYDES, AND BIOGENIC AMINES

1973 • 17 citations

Differential tolerance to pentobarbital in rats bred for differences in alcohol sensitivity

1978 • 17 citations

Inhibition of the Formation of Tetrahydroisoquinoline Alkaloids in Brain Homogenates

1973 • 17 citations

IDENTIFICATION OF ISOQUINOLINE ALKALOIDS DURING ALCOHOL INTOXICATION**The technical assistance and cooperation of Mostafa Bigdeli, Frank Letizia, Cynthia Weiner, and Diane Konrad are gratefully acknowledged. Supported in part by Loyola GRS and USPHS NIAAA 00266.

1977 • 16 citations

Brain Catecholamines and Ethanol: Involvement in Physical Dependence and Withdrawal

1977 • 16 citations

Noradrenaline receptor sensitivity after chronic ethanol administration

1978 • 16 citations

Enzymes of Biogenic Aldehyde Metabolism

1975 • 16 citations

Identification of Tetrahydronorharmane (Tetrahydro-β-carboline) in Human Blood Platelets

1980 • 16 citations

Effects of Phenobarbital and Ethanol on Rat Liver Aldehyde Dehydrogenases

1974 • 16 citations

HUMAN LIVER ALDEHYDE DEHYDROGENASE

1977 • 16 citations

Ethanol-induced changes in activities of adenylate cyclase, guanylate cyclase and cyclic adenosine 3′,5′-monophosphate dependent protein kinase in the brain and liver

1977 • 16 citations

Metabolism of Calcium and Magnesium during Ethanol Intoxication and Withdrawal

1979 • 15 citations

ROLE OF SEROTONIN (5-HT) IN DRUG TOLERANCE AND GENERAL ADAPTATION

1980 • 15 citations

The role of physical dependence in animal models of human alcoholism

1976 • 15 citations

Effect of ethanol on dop amine synthesis in rat striatal synaptosomes

1977 • 15 citations

Rapid adaptation to neuronal membrane effects of ethanol and low temperature: Some speculations on mechanism

1979 • 15 citations

SALSOLINOL AND SALSOLINE IN CEREBROSPINAL LUMBAR FLUID OF ALCOHOLIC PATIENTS

1980 • 15 citations

Effect of Ethanol on Intracellular Respiration and Cerebral Function

1971 • 15 citations

The Question of a Genetic Basis for Alcoholism; Comment on the Study by Goodwin et al., and a Response

1973 • 15 citations

Microsomal Ethanol Oxidation: Activity in Vitro and in Vivo

1975 • 15 citations

Role of Catecholamines in the Development of Tolerance to Barbiturates and Ethanol

1977 • 15 citations

Ethanol tolerance and ethanol-drug interactions in the rat

1972 • 15 citations

Stereoselective interaction of tetrahydroisoquinolines in β-adrenoceptor systems

1978 • 14 citations

Is there a correlation between the concentration of beta-carbolines and their pharmacodynamic effects?

1982 • 14 citations

Neurochemical aspects in pathogenesis of alcohol and drug dependence

1979 • 14 citations

Inhibition by tetrahydroharmane compounds of 5-hydroxytryptamine and histamine uptake in rabbit blood platelets

1973 • 14 citations

ALTERATIONS IN NEUROTRANSMITTER FUNCTION DURING THE DEVELOPMENT OF ETHANOL TOLERANCE AND DEPENDENCE

1980 • 14 citations

FUTURE RESEARCH ON OPIOID PEPTIDES (ENDORPHINS): A PREVIEW

1977 • 14 citations

Peptide-neurotransmitter interactions influencing ethanol tolerance

1979 • 14 citations

ETHANOL AND ACETALDEHYDE METABOLISM DURING ETHANOL CONSUMPTION

1977 • 14 citations

Harmaline inhibits the (Na+ + K+)-dependent ATPase by affecting both Na+ and K+ activation

1975 • 14 citations

Determination of Hepatic Acetaldehyde and its Biphasic Relationship to the Ethanol Concentration in Rats

1980 • 14 citations

Metabolic changes after prior treatment with ethanol. Evidence against in involvement of the Na+ + K+-activated ATPase in the increase in ethanol metabolism

1980 • 14 citations

Effect of Acute and Chronic Administration of Ethanol on the Redox States of Brain and Liver

1979 • 13 citations

Alteration in Cerebral Polynucleotide Metabolism Following Chronic Ethanol Ingestion

1975 • 13 citations

INHIBITION OF CATALASE IN PERFUSED RAT LIVER BY SODIUM AZIDE*

1969 • 13 citations

Interactions of Opiates and Endorphins With Cerebral Catecholamines

1980 • 13 citations

Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs

1975 • 13 citations

Electrical stimulation and lesions of the medial forebrain bundle of the rat: Changes in voluntary ethanol consumption and brain aldehyde dehydrogenase activity

1978 • 13 citations

Effect of ethanol on central gabaergic mechanisms

1980 • 13 citations

Stimulation of Ethanol Metabolism by Catecholamines

1980 • 12 citations

Role of serotonin in tolerance to ethanol and barbiturates: Evidence for a specific vs. non-specific concept of tolerance

1979 • 12 citations

Mitochondrial function following chronic ethanol treatment: effect of diet.

1980 • 12 citations

Genetic and Experiential Antecedents of Alcoholism: A Prospective Study

1977 • 12 citations

Naloxone antagonizes the action of low ethanol concentrations on mouse vas deferens.

1980 • 12 citations

Cross-Tolerance between Ethanol and Morphine

1980 • 12 citations

A NOVEL ROUTE FOR THE METABOLISM OF ETHANOL; THE OXIDATION OF ETHANOL BY HYDROXYL FREE RADICALS

1977 • 12 citations

Interaction of Biogenic Amines with Ethanol

1975 • 12 citations

Effect of ethanol on cyclic nucleotides in vivo: Consequences of controlling motor and respiratory changes

1979 • 12 citations

Ethanol Metabolism, Oxygen Availability and Alcohol Induced Liver Damage

1977 • 12 citations

Biosynthesis of Tetrahydroisoquinoline Alkaloids in Brain and other Tissues of Ethanol-Intoxicated Rats

1975 • 12 citations

Inhibition of High Affinity Calcium Binding by Salsolinol

1978 • 12 citations

Metabolism of Alcohol at High Concentrations: Role and Biochemical Nature of the Hepatic Microsomal Ethanol Oxidizing System

1977 • 12 citations

Kinetic Studies on NADPH-Linked Aldehyde Reductase from Human Liver

1980 • 12 citations

Centrally acting peptides and tolerance to ethanol.

1981 • 12 citations

The Role of Liver Cytosolic Aldehyde Dehydrogenase in Ethanol Metabolism in DBA and C57Bl Mice

1980 • 11 citations

Amine-aldehyde metabolites and alcoholism: fact, myth or uncertainty.

1980 • 11 citations

Relationship between brain levels of cyclic nucleotides and γ-aminobutyric acid during ethanol withdrawal in rats

1977 • 11 citations

Ethanol preference as a function of genotypic levels of whole brain enkephalin in mice.

1981 • 11 citations

Effect of acute and chronic administration of ethanol on the 5-hydroxytryptamine turnover and tryptophan hydroxylase activity of the mouse brain

1971 • 11 citations

Multiple Aldehyde Reductases of Human Brain

1980 • 11 citations

Effects of Chronic Ethanol Consumption on the Respiratory Chain of Rat Liver Submitochondrial Particles

1980 • 11 citations

Opiate Receptors and Endogenous Opioid Peptides in Tolerance and Dependence

1977 • 11 citations

Cyclic nucleotides and ethanol tolerance and dependence

1979 • 11 citations

Adaptive changes in membrane lipid composition and fluidity as the basis for ethanol tolerance

1979 • 11 citations

Alcohol membrane interaction in the brain: biological adaptation.

1979 • 11 citations

PHARMACOLOGY OF ISOQUINOLINE ALKALOIDS AND ETHANOL INTERACTIONS**This research was supported in part by a Defence Research Board of Canada grant. A.M. is a recipient of an Alcoholism and Drug Addiction Foundation Research scholarship.

1977 • 11 citations

CHEMICAL PATHOLOGY AND PHARMACOLOGY

1974 • 11 citations

Effects of tetrahydropapaveroline and salsolinol on cerebral monoamine metabolism and their interactions with psychopharmacological drugs

1979 • 11 citations

Catecholaminergic Involvement in Alcohol’s Rewarding Properties: Implications for a Treatment Model for Alcoholics

1977 • 11 citations

On the Role of Endorphins in Addiction

1982 • 11 citations

The use of tert-butanol in alcohol dependence studies.

1976 • 10 citations

Calcium Receptor Binding in Synaptic Membranes of ICR, C57, DBA Mice After Ethanol Exposure

1980 • 10 citations

Mechanism of the Magnesium Ion Activation of the Catalytic Activity of Horse Liver Aldehyde Dehydrogenase

1980 • 10 citations

Effects of Ethanol on the Cholinergic System

1979 • 10 citations

Rat Brain Cyclic Amp Levels and Withdrawal Behavior following Treatment with t-Butanol

1980 • 10 citations

On the Possible Relationship of Cytochrome P-450 to Alcohol Metabolism: Fundamental Aspects of the Microsomal Hydroxylation System, Including Properties and Interactions of the Components

1980 • 10 citations

Decreasing acetaldehyde levels with 4-methylpyrazole does not increase voluntary ethanol drinking by rats

1979 • 10 citations

Cyclic adenosine 3′,5′-monophosphate, adenylate cyclase and physical dependence on ethanol: Studies with tranylcypromine

1977 • 10 citations

[Pharmacological study of a possible dopamine metabolite, tetrahydropapaveroline].

1971 • 10 citations

Effect of Ethanol and Acetaldehyde on Membrane-Bound Enzymes in Rat Brain

1980 • 10 citations

Effects of Acute and Chronic Administration of Ethanol on Cyclic Nucleotides and Related Systems

1979 • 10 citations

Mechanism of the Swift Increase in Alcohol Metabolism (“SIAM”) in the Rat

1980 • 10 citations

Brain Polynucleotide Metabolism Following Long-Term Ethanol Ingestion

1977 • 10 citations

INTRODUCTION Neurotransmitter Function and Alcoholism

1979 • 10 citations

Dependence of Mitochondrial and Cytosolic ATP Systems on the Metabolic State of Perfused Rat Liver

1980 • 10 citations

Involvement of Lipids in the Action of Ethanol and Other Anesthetics

1980 • 10 citations

Quantitative correlation of ethanol elimination rates in vivo with liver alcohol dehydrogenase activities in fed, fasted and food-restricted rats

1979 • 10 citations

Adaptation of cyclic AMP generating system in rat cerebral cortical slices during chronic ethanol treatment and withdrawal

1981 • 10 citations

REVERSAL OF TOLERANCE TO ETHANOL—A POSSIBLE CONSEQUENCE OF ETHANOL BRAIN DAMAGE

1980 • 10 citations

Behavioral Changes after Chronic Ethanol Treatment

1977 • 9 citations

Effects of phenobarbital, phenylbutazone, 3,4-benzpyrene, or 3-methylcholanthrene on ethanol metabolism in the rat

1970 • 9 citations

Physiological role of aldehyde dehydrogenase isozymes.

1982 • 9 citations

Adrenergic subsensitivity of the rat brain during chronic ethanol ingestion.

1974 • 9 citations

The Effects of Ethanol on Dopamine Metabolism in Rat Liver and Brain

1977 • 9 citations

Strain Differences in the Development of Acute Tolerance to Ethanol

1980 • 9 citations

Ethanol-Inducible Liver Cytochrome P-450 in the Rat: Relative Specificity for Ethanol Oxidation Activity in Vitro

1980 • 9 citations

Aldehyde dehydrogenase inducibility and ethanol preference in rats.

1975 • 9 citations

International titisee symposium on alcohol metabolism in humans and its enzymes titisee west germany jan. 21 24 1982

1982 • 9 citations

Behavioral and biochemical effects of intracerebrally injected alkaloids

1979 • 9 citations

1-methyl-6-hydroxytetrahydrocarboline: A possible product of ethanol and tryptophan metabolism

1973 • 9 citations

Acetaldehyde and Acetate Production during Ethanol Metabolism in Perfused Rat Liver

1980 • 9 citations

Metabolic consequences of chronic alcohol consumption: attenuation of hepatic redox changes despite enhanced capacity to eliminate ethanol.

1979 • 9 citations

Alcohol-related tetrahydroisoquinolines: pharmacology and identification.

1980 • 9 citations

The Effect of Chronic Ethanol Consumption on the Rate of Whole Animal and Perfused Liver Oxygen Consumption

1980 • 8 citations

Effects of catecholic tetrahydroisoquinolines on endogenous catecholamines.

1979 • 8 citations

MAO Activity in Rat Brain Stem and Cerebral Cortex: Effect of Acute and Chronic Treatment with Ethanol and Tetrahydropapaveroline

1978 • 8 citations

Genotype dependent responses to ethanol and normorphine on vas deferens of inbred strains of mice.

1980 • 8 citations

Addiction to Barbiturates and Ethanol: Possible Biochemical Mechanisms

1973 • 8 citations

HEPATIC ACETALDEHYDE METABOLISM DURING ETHANOL OXIDATION

1977 • 8 citations

The Neural Basis of Ethanol Dependence: is the Withdrawal Reaction Mediated by Localized Changes in Synaptic Excitability?

1980 • 8 citations

Chronopharmacokinetics of Ethanol

1979 • 8 citations

Physical Dependence on Ethanol: Methodological Considerations

1980 • 8 citations

Ethanol and the Blood-Brain Barrier

1979 • 8 citations

Interaction of Ethanol with Other Drugs

1979 • 8 citations

Modification of Dopamine Receptor-Mediated Processes After Chronic Ethanol Intoxication: A Possible Mechanism

1980 • 8 citations

Regulatory Factors of Acetaldehyde Metabolism in Isolated Rat Liver Mitochondria

1977 • 8 citations

Regulation of Acetaldehyde Metabolism During Ethanol Oxidation in Perfused Rat Liver

1977 • 8 citations

Noradrenergic subsensitivity of rat liver homogenates during chronic ethanol ingestion.

1976 • 8 citations

Effects of Ethanol on Membrane Transport

1979 • 8 citations

Reduction in voluntary ethanol consumption by treatment with alcohol dehydrogenase inhibitors.

1980 • 7 citations

Estimation of the in vivo concentration of salsolinol and tetrahydropapaveroline in rat brain after the administration of ethanol.

1980 • 7 citations

Antagonism of Ethanol’s Central Stimulation by Catecholamine Receptor Agonists

1980 • 7 citations

Die Endorphine: ein Schlüssel zum Verständnis von Schmerz, Sucht und psychischen Störungen?

1979 • 7 citations

Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates

1980 • 7 citations

ON THE QUESTION OF WHETHER CYTOCHROME P-450 CATALYZES ETHANOL OXIDATION: STUDIES WITH PURIFIED FORMS OF THE CYTOCHROME FROM RABBIT LIVER MICROSOMES11This research was supported by Grant PCM76-14947 from the National Science Foundation and Grant AM-10339 from the United States Public Health Service.

1977 • 7 citations

Half-Lives and Actions of Intracerebrally Injected Isoquinolines

1980 • 7 citations

Receptor and Membrane Function in the Alcohol Tolerant/Dependent Animal

1980 • 7 citations

The Synaptic Properties of Some Tetrahydroisoquinoline Alkaloids

1978 • 7 citations

Drug dependence as an adaptive response: studies with ethanol in mice.

1975 • 7 citations

Tetrahydroisoquinolines and the serotonergic system

1979 • 7 citations

Ethanol Elimination is Inherited in the Rat

1980 • 7 citations

Interaction of Ethanol with Other Drugs

1983 • 7 citations

In Vivo Significance of the Microsomal Ethanol Oxidizing System (MEOS)

1977 • 7 citations

INTERACTION OF THE ADP, ATP TRANSPORT WITH THE SYSTEM OF OXIDATIVE PHOSPHORYLATION

1977 • 6 citations

Role of hepatic microsomal ethanol metabolism

1971 • 6 citations

Absence of blood acetaldehyde differences between alcoholics and controls after ethanol ingestion

1980 • 6 citations

RECONSTITUTION OF THE HEPATIC MICROSOMAL ETHANOL OXIDIZING SYSTEM (MEOS) IN CONTROL RATS AND AFTER ETHANOL FEEDING

1977 • 6 citations

Localization of sites in the brain mediating alcohol drinking induced by tetrahydropapaveroline (THP).

1979 • 6 citations

Temporal Patterns of Voluntary Alcohol Intake

1977 • 6 citations

Adaptive changes in the responsiveness of adenylate cyclase to catecholamines

1979 • 6 citations

Adaptive changes in the dopamine system produced by chronic ethanol feeding

1979 • 6 citations

On the Possibility that Opiate and Ethanol Actions are Mediated by Similar Mechanisms

1977 • 6 citations

Lack of evidence for sustained blood acetaldehyde concentrations during alcohol detoxification.

1978 • 6 citations

Effects of Aliphatic Alcohols and Aldehydes on Fluidity of Spin-Labeled Synaptosomal Plasma Membranes

1980 • 6 citations

Chemical Sympathectomy Due to Tetrahydroisoquinolines Derived from Adrenaline

1980 • 6 citations

MECHANISM OF INCREASED HEPATIC OXYGEN UPTAKE DUE TO ETHANOL

1977 • 6 citations

The swift increase in alcohol metabolism.

1981 • 5 citations

STUDIES ON THE EFFECTS OF TETRAHYDROISOQUINOLINE DERIVATIVES OF CATECHOLAMINES AND ALDEHYDES ON TYROSINE HYDROXYLASE

1977 • 5 citations

ALCOHOL METABOLISM IN HUMANS AND ITS ENZYMES

1982 • 5 citations

KINETICS OF ALTERATIONS IN BRAIN CYCLIC AMP LEVELS DURING ETHANOL TREATMENT AND WITHDRAWAL

1977 • 5 citations

Alterations of Macromolecule Biosynthesis after Chronic Administration of Opiates and Ethanol

1977 • 5 citations

Alterations of Hepatic Alcohol Metabolizing Enzyme Activities Due to Thyroid Hormones

1980 • 5 citations

Physical dependence on ethanol: Conceptual considerations

1979 • 5 citations

Brain Neurotransmitter Receptor Systems in Alcohol Treated Mice and in Mice Genetically Selected for Differences in Sensitivity to Alcohol

1980 • 5 citations

MECHANISM OF THE FRUCTOSE EFFECT ON ETHANOL OXIDATION

1977 • 5 citations

Role of Hydroxyl Radicals in Microsomal Oxidation of Alcohols

1980 • 5 citations

Mechanism of Inhibition of Mixed-Function Oxidation by Ethanol

1980 • 5 citations

The Effect of Alcohol on Dopamine Metabolism in the Caudate Nucleus of an Unanesthetized Monkey

1980 • 5 citations

Cyclic Amp And ß-Adrenergic Receptors during The Development Of Physical Dependence On Ethanol In The Rat

1980 • 5 citations

Analysis of the dopamine-derived tetrahydroisoquinoline salsolinol in urine and cerebrospinal fluid from alcoholics and healthy volunteers

1980 • 5 citations

Degradation Characteristics of Two Tetrahydroisoquinolines at Room and Body Temperatures: HPLC Determination with Electrochemical Detection

1983 • 5 citations

A MECHANISM FOR ALTERED ADRENERGIC ACTIVITY IN ALCOHOLISM

1977 • 5 citations

Alteration in serum tyrosine and tryptophan concentrations associated with the induction of physical dependence on ethanol in mice

1978 • 5 citations

The Acute Effects of Ethanol on Liver and Brain Tryptophan Metabolism

1977 • 5 citations

FACTORS ALTERING THE RATE OF ALCOHOL METABOLISM IN HEPATOCYTES

1977 • 4 citations

EFFECTIVENESS OF FRUCTOSE IN THE MANAGEMENT OF ALCOHOL WITHDRAWAL SYNDROME IN MAN

1977 • 4 citations

Effect of 4-Methylpyrazole and Abstinence on Ethanol elimination in an alcoholic

1979 • 4 citations

Alterations of Cyclic Nucleotide Metabolism in Brain Following Ethanol Intoxication and Withdrawal

1977 • 4 citations

Genetically Mediated Responses of Microsomal Ethanol Oxidation in Mice

1980 • 4 citations

LOCALIZATION AND PROPERTIES OF ALDEHYDE REDUCTASE

1977 • 4 citations

EVIDENCE FOR THE DIRECT INVOLVEMENT OF HEPATIC CYTOCHROME P450 IN ETHANOL METABOLISM

1977 • 4 citations

Development and reversal of tolerance and its relationship to physical dependence on ethanol in the rat.

1981 • 4 citations

Measures of Physical Dependence and Involvement of Serotonin in Withdrawal Symptomatology

1977 • 4 citations

ETHANOL, NOT ACETALDEHYDE, DETERMINES SEVERITY OF WITHDRAWAL SEIZURES IN MICE

1977 • 4 citations

DISTRIBUTION AND REGULATION OF CYCLIC NUCLEOTIDES LEVELS IN BRAIN, IN VIVO**This study was supported in part by USPHS Grants NS-09667 and GM-02016.

1977 • 3 citations

Monoamine Oxidase and the Enzymes of Ethanol Metabolism in Rats After Administration of Tetrahydroisoquinolines

1980 • 3 citations

Effect of ethanol concentration on rates of ethanol elimination in normal rats in vivo.

1979 • 3 citations

INDUCTION11We have referred to “induction” of aldehyde dehydrogenase throughout this paper to signify an increase in enzyme activity. Although we have some evidence from immunological studies that there is a corresponding increase in enzyme protein, these studies are not yet complete. OF CYTOSOLIC ALDEHYDE DEHYDROGENASE ISOZYMES: INFLUENCE ON ACETALDEHYDE METABOLISM

1977 • 3 citations

Ethanol effects on the dopaminergic function: Modulation by the enkephalinergic system

1980 • 3 citations

Neurohypophyseal peptide influences on ethanol tolerance and acute effects of ethanol

1980 • 3 citations

INTERACTION AND ACTIVITIES OF NAD+ AND NAD+ ANALOGS WITH FOUR DEHYDROGENASES

1977 • 3 citations

The Effect of Chronic Ethanol Consumption on Pathways of Ethanol Metabolism

1980 • 3 citations

Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse

1980 • 3 citations

CHANGES OF BRAIN CYCLIC NUCLEOTIDES INDUCED BY ETHANOL ADMINISTRATION AND WITHDRAWAL

1977 • 3 citations

Ethanol, Acetaldehyde, and the Metabolism of Perfused Brain

1979 • 3 citations

Effect of alpha- and beta-blockers on ethanol metabolism

1979 • 3 citations

Comparison of a physical dependence on t-butanol and ethanol

1979 • 3 citations

Cytotoxic Effects of Alcohol on the Liver

1977 • 3 citations

Interactions of Ethanol, Drug and Lipid Metabolism; Adaptive Changes after Ethanol Consumption

1970 • 3 citations

Fluidizing effects of ethanol and temperature at different depths in the membrane

1980 • 3 citations

Reversal of Tolerance to Ethanol Associated with the Induction of Physical Dependence on Ethanol in the Rat

1980 • 3 citations

REGULATION OF ALCOHOL OXIDATION IN MAN: INHIBITION (FASTING) AND STIMULATION (PHENOBARBITAL TREATMENT OR CHRONIC ALCOHOL CONSUMPTION) IS EQUALIZED BY FRUCTOSE INFUSION

1977 • 3 citations

Ethanol as a Selective Inhibitor of Microsomal Barbiturate Hydroxylation in Vitro and in Vivo

1980 • 3 citations

MICROSOMAL ELECTRON TRANSPORT REACTIONS: THE FORMATION AND UTILIZATION OF HYDROGEN PEROXIDE AS RELATED TO ALCOHOL METABOLISM**Supported in part by a grant from the National Institutes of Health (5RO1-GM-16488).

1977 • 3 citations

QUANTITATION OF PATHWAYS RESPONSIBLE FOR NADPH-DEPENDENT METHANOL, ETHANOL, AND BUTANOL OXIDATION BY HEPATIC MICROSOMES**Supported, in part, by grants from the National Institute of Alcohol Abuse and Alcoholism, AA-00288 and K02 AA-70155.

1977 • 3 citations

Tetrahydropapaveroline Inhibits Dopamine Uptake in Rat Brain Synaptosomes

1980 • 3 citations

STUDIES ON THE CHARACTERIZATION OF THE ENZYME COMPONENTS PARTICIPATING IN THE HEPATIC-MICROSOMAL OXIDATION OF ALIPHATIC ALCOHOLS

1977 • 3 citations

Ethanol, protein metabolism and liver injury

1980 • 3 citations

ACETALDEHYDE OCCURRENCE IN CEREBROSPINAL FLUID AND ITS DEPENDENCE ON THE BLOOD LEVEL AND ON ALDEHYDE DEHYDROGENASE INHIBITORS

1977 • 2 citations

Self-Administration of Sedatives by Humans

1977 • 2 citations

Cyclic nucleotides in the development of alcohol tolerance and dependence: A commentary

1979 • 2 citations

The Effects of Sodium Phenobarbital on Voluntary Ethanol Consumption in Rats

1977 • 2 citations

Involvement of neurohypophyseal peptides in drug-mediated adaptive responses

1980 • 2 citations

Interaction of ethanol with gamma-aminobutyric acid receptor binding sites in brain

1980 • 2 citations

Neuronal Aspects of Opiate Dependence and Tolerance in Comparison to Central Depressants

1977 • 2 citations

[Alcohol-psychotropic drug interactions].

1976 • 2 citations

Multifunctionality of Liver Alcohol Dehydrogenase

1980 • 2 citations

MALFUNCTION OF DOPAMINE SYSTEMS IN ETHANOL-DEPENDENT ANIMALS

1979 • 2 citations

Lipid regulation of a Ca2+ transport protein after ethanol treatment

1980 • 2 citations

Opiate receptor function after acute and chronic ethanol exposure

1980 • 2 citations

Comparison between the Effects of Ethanol and Those of Opioid Drugs on the Metabolism of Biogenic Amines

1979 • 2 citations

LOWERING OF BLOOD ACETALDEHYDE LEVELS AS A THERAPERTIC APPROACH TO ALCOHOLISM

1977 • 2 citations

Genetic differences in opiate receptor function. Abstr.

1983 • 2 citations

Holism: A Social Pharmacological Approach to Drug-Seeking Behavior

1981 • 2 citations

(Na+ + K+)adenosine triphosphatase activity in synaptic and myelin membranes isolated from rat brain: Effect of ethanol

1980 • 1 citations

Effect of pyrazole and 4-methylpyrazole on in vivo and in vitro acetaldehyde metabolism in the rat

1980 • 1 citations

Altered Response to Cessation of Nerve Impulse Flow in Dopamine Neurons After Chronic Ethanol Administration

1980 • 1 citations

Alteration of membrane permeability by ethanol (lithium and vanadate)

1980 • 1 citations

Blood acetaldehyde levels in rats: Effect of L-ascorbic acid alone or in combination with L-cysteine and thiamin hydrochloride administered orally and intraperitoneally

1980 • 1 citations

The Metabolism of Biogenic Amines in Experimental Animals and in Human Subjects during Acute and Chronic Administration of Ethanol

1977 • 1 citations

Interactions of Thyrotropin-Releasing Hormone and Somatostatin with Ethanol and Other Sedative/Hypnotics

1979 • 1 citations

Alcohol and catecholamine disposition: A role for tetrahydroisoquinoline alkaloids

1973 • 1 citations

THE OXIDATION OF ACETALDEHYDE BY RAT HEPATIC, NON-HEPATIC AND TUMOR MITOCHONDRIA

1977 • 1 citations

5. The Effect of Ethanol on Liver Metabolism

1970 • 1 citations

Further studies on catecholamine-ethanol interaction on rat brain (Na+ + K+)ATPase

1980 • 1 citations

Alcohol Metabolism at High Alcohol Concentrations

1977 • 1 citations

ACETALDEHYDE OXIDATION BY ISOLATED HEPATIC ALDEHYDE DEHYDROGENASE, MITOCHONDRIA AND PARENCHYMAL CELLS, AND BY PERFUSED INTACT LIVER OF THE RAT

1977 • 1 citations

STIMULATION OF HEPATIC ACETALDEHYDE UPTAKE IN PERFUSED RAT LIVER BY FRUCTOSE

1977 • 1 citations

Common Mechanism for the Adaptive Increase in Hepatic Ethanol and Acetaldehyde Metabolism Due to Chronic Pretreatment with Ethanol

1977 • 1 citations

Pharmacological manipulation of opiate-like peptide systems

1980 • 1 citations

MODIFICATION OF TRYPTOPHAN IN LIVER ALCOHOL DEHYDROGENASE

1977 • 1 citations

Effects of morphine and ethanol tolerance and withdrawal on pituitary endorphin-like immunoreactivity

1980 • 1 citations

Induction of hepatic microsomal ethanol-oxidizing system activity following chronic ethanol consumption: Respective roles of ethanol and carbohydrates

1980 • 1 citations

Deleted Work

1955 • 0 citations