Toxic effects of ethanol: Possible role of acetaldehyde, tetrahydroisoquinolines, and tetrahydro-β-carbolines

The role of calcium in the release of neurotransmitter substances and hormones.

1970 • 871 citations

Textbook of Endocrinology.

1975 • 643 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

1970 • 441 citations

Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal Reaction

1971 • 437 citations

Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man

1973 • 369 citations

An Electrochemical Detector for Liquid Chromatography with Picogram Sensitivity

1973 • 355 citations

THE DISTRIBUTION OF SEROTONIN, 5‐HYDROXYTRYPTOPHAN DECARBOXYLASE, AND MONOAMINE OXIDASE IN BRAIN*

1957 • 350 citations

Relationship of alcohol dose to intensity of withdrawal signs in mice.

1972 • 329 citations

The metabolism of ethanol and its metabolic effects.

1972 • 291 citations

COMPOUNDS OF THIOL ACIDS WITH ALDEHYDES

1936 • 252 citations

THE ROLE OF ACETALDEHYDE IN THE ACTIONS OF ETHANOL

1975 • 250 citations

Tissue and subcellular distribution of mammalian aldehyde-oxidizing capacity

1966 • 237 citations

New high performance liquid chromatographic analysis of brain catecholamines

1974 • 236 citations

The physiological role of liver alcohol dehydrogenase

1970 • 225 citations

Biological aspects of alcohol

1971 • 223 citations

On the Effects of Some Heterocyclic Compounds on the Enzymic Activity of Liver Alcohol Dehydrogenase.

1969 • 218 citations

Comparison of the effects of dopamine, isoproterenol, norepinephrine and bradykinin on canine renal and femoral blood flow.

1966 • 214 citations

A review of methods to induce alcohol addiction in animals

1973 • 210 citations

The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man.

1967 • 192 citations

Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds

1958 • 177 citations

Inhibition of ethanol metabolism in vivo by administration of pyrazole

1969 • 159 citations

Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication

1975 • 149 citations

Pyrazole Inhibition and Kinetic Studies of Ethanol and Retinol Oxidation Catalyzed by Rat Liver Alcohol Dehydrogenase.

1969 • 140 citations

The Metabolism of Melatonin (N-Acetyl-5-methoxytryptamine) and 5-Methoxytryptamine

1961 • 136 citations

Adrenal Function and Alcoholism

1971 • 135 citations

Ethanol-induced alterations of norepinephrine metabolism in man.

1967 • 131 citations

Effects of ethanol and acetaldehyde on the heart

1967 • 126 citations

Tetrahydroisoquinoline alkaloids: uptake by rat brain homogenates and inhibition of catecholamine uptake.

1971 • 125 citations

Blood Concentrations of Acetaldehyde and Ethanol in Chronic Alcoholics

1970 • 123 citations

An animal model for testing effects of drugs on alcohol withdrawal reactions.

1972 • 118 citations

Tetrahydropapaveroline : Formation and in rat brain

1974 • 117 citations

Salsolinol, an Alkaloid Derivative of Dopamine formed in vitro during Alcohol Metabolism

1970 • 116 citations

Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro.

1970 • 115 citations

Parkinsons disease and its chemotherapy

1975 • 113 citations

Dopamine-derived tetrahydroisoquinoline alkaloids—Inhibitors of neuroamine metabolism

1973 • 105 citations

Effect of Pyrazoles and Other Compounds on Alcohol Metabolism

1968 • 100 citations

Beta-Adrenergic Receptor Blocking Drugs in Psychiatry

1974 • 99 citations

Formation of 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline under physiological conditions

1961 • 96 citations

Acetaldehyde—an inhibitor of the enzymatic oxidation of 5-hydroxyindoleacetaldehyde

1969 • 93 citations

Protection against Acetaldehyde Toxicity in the rat byl-cysteine, thiamin andl-2-Methylthiazolidine-4-carboxylic acid

1974 • 92 citations

Synthesis of Isoquinolines. III. A New Synthesis of 1,2,3,4-Tetrahydroisoquinolines¹

1965 • 91 citations

Possible New Metabolites mediating Actions of L-Dopa

1971 • 89 citations

STUDIES ON TETRAHYDROISOQUINOLINES (THI) (I) BRONCHODILATOR ACTIVITY AND STRUCTURE-ACTIVITY RELATIONSHIP

1967 • 87 citations

Ethanol Preference in the Rat as a Function of Photoperiod

1971 • 85 citations

Brain Alcohol Dehydrogenase

1968 • 83 citations

Simple Isoquinoline Alkaloids

1986 • 81 citations

A Biochemical Concept of Mental Disease

1961 • 81 citations

A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence

1974 • 77 citations

Pharmakologie des Tetrahydropapaverolins und seine Entstehung aus Dopamin

1964 • 76 citations

The action of L-dopa on schizophrenic patients (a preliminary report).

1970 • 74 citations

The Pineal Organ

1974 • 71 citations

Formation of Tetrahydropapaveroline from Dopamine in vitro

1964 • 70 citations

6,7-Dihydroxytetrahydroisoquinoline: Uptake and Storage by Peripheral Sympathetic Nerve of the Rat

1972 • 68 citations

Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro.

1970 • 67 citations

Mechanism of sympathomimetic action of aldehydes.

1959 • 63 citations

Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice

1971 • 61 citations

Morphine and Ethanol Physical Dependence: A Critique of a Hypothesis

1970 • 60 citations

Tetrahydroisoquinoline alkaloids: stimulated secretion from the adrenal medulla.

1973 • 59 citations

The control of essential tremor by propranolol.

1971 • 58 citations

Observations on the formation of ethanol in the intestinal tract in man

1971 • 58 citations

Alcohol withdrawal reactions and reserpine effects in inbred strains of mice

1974 • 58 citations

Characterization of Endogenous Ethanol in the Mammal

1960 • 58 citations

Tetrahydroisoquinoline alkaloids in the adrenal medulla after perfusion with “blood concentrations” of [14C]acetaldehyde

1971 • 55 citations

Tetrahydroisoquinoline alkaloids: Uptake and release by adrenergic nerves in vivo

1974 • 54 citations

Sympathomimetic effects of acetaldehyde on the electrical and contractile characteristics of isolated left atria of guinea pigs.

1969 • 53 citations

MODERN NUTRITION IN HEALTH AND DISEASE

1969 • 52 citations

Alcohol Addiction and Tetrahydropapaveroline

1970 • 50 citations

Inhibition of catechol-O-methyl transferase by pyrogallol in the rat

1961 • 50 citations

The induction of ethanol dependence and the ethanol withdrawal syndrome: the effects of pyrazole

1974 • 44 citations

The Replacement by Thiazolidinecarboxylic Acid of Exogenous Cystine and Cysteine

1958 • 42 citations

The action of tetrahydropapaveroline hydrochloride

1910 • 42 citations

Comparison of acetaldehyde and ethanol: Depression of motor activity in mice

1974 • 40 citations

The effect of acetaldehyde on rat brain mitochondria and its occurrence in brain after alcohol injection

1962 • 39 citations

Identification of catecholamine-derived alkaloids in mammals by gas chromatography and mass spectrometry

1974 • 38 citations

STUDIES ON SYMPATHOMIMETIC ACTION OF ACETALDEHYDE

1965 • 38 citations

6,7-dihydroxytetrahydroisoquinoline: Electron microscopic evidence for uptake into the amine-binding vesicles in sympathetic nerves of rat iris and pineal gland

1973 • 37 citations

Acetaldehyde mediation in the mechanism of ethanol-induced changes in norepinephrine metabolism.

1970 • 36 citations

Cardiac effects of some simple aliphatic aldehydes.

1968 • 36 citations

Pharmacological properties of tetrahydropapaveroline

1967 • 34 citations

The Effect of Acetaldehyde on the Secretion of Adrenaline and Korndrenaline from the Suprarenal Gland of the Cat

1958 • 34 citations

The role of intracellular calcium in catecholamine secretion from the bovine adrenal medulla.

1973 • 33 citations

Acetaldehyde-induced catecholamine secretion from the cow adrenal medulla.

1971 • 33 citations

Alteration of Endogenous Catecholamine Metabolism by Ethanol Ingestion.

1967 • 32 citations

Uptake and accumulation of 3H-6,7-dihydroxytetrahydroisoquinoline by peripheral sympathetic nerves in vivo.

1973 • 32 citations

The effects of acetaldehyde on serotonin metabolism

1967 • 31 citations

NEUROAMINE‐DERIVED ALKALOIDS: A POSSIBLE COMMON DENOMINATOR IN ALCOHOLISM AND RELATED DRUG DEPENDENCIES

1973 • 31 citations

Tissue catecholamines and potential tetrahydroisoquinoline alkaloid metabolites: A gas chromatographic assay method with electron capture detection

1975 • 31 citations

Speculations on the biochemical pharmacology of ethanol

1974 • 30 citations

Two new alkaloids in cacti

1967 • 29 citations

The Role of Acetaldehyde in the Actions of Ethanol

1971 • 29 citations

Alcohol Intoxication and Withdrawal

2006 • 29 citations

Cardiovascular effects of intravenous acetaldehyde and propionaldehyde in the anesthetized rat

1973 • 28 citations

Hypothermia following intraventricular injection of a dopamine-derived tetrahydroisoquinoline alkaloid

1973 • 26 citations

Ethanol Consumption by Rats under Different Lighting Conditions

1972 • 26 citations

A Role for Tetrahydroisoquinoline Alkaloids as False Adrenergic Neurotransmitters in Alcoholism

1973 • 26 citations

A FURTHER INSIGHT INTO THE METABOLISM OF CERTAIN βCARBOLINES

1973 • 26 citations

Does tetrahydropapaveroline contribute to the cardiovascular actions of dopamine?

1968 • 26 citations

Catecholamine‐related isoquinoline alkaloids. 1. Synthesis of 4‐hydroxytetrahydroisoquinoline analogs of adrenaline and metanephrine

1972 • 25 citations

Pressor Response to Acetaldehyde and Its Potentiation by Cocaine.

1943 • 23 citations

CENTRAL NERVOUS SYSTEM DISTRIBUTION AND METABOLISM OF C-14-MORPHINE DURING MORPHINE-INDUCED FELINE MANIA.

1965 • 23 citations

Inhibiting action of n-butyraldoxime on ethanol metabolism and on natural ethanol preference of C57BL mice.

1970 • 22 citations

Comparative actions of the trimetoquinol, tetrahydropapaveroline and salsolinol isomers in ß-adrenoceptor systems

1975 • 22 citations

Tetrahydroisoquinolines and the catecholamine-binding granules of the adrenal medulla

1972 • 22 citations

Reduction of acute alcoholic intoxication by α amino acids: Glycine and serine

1974 • 22 citations

Effect of lysine on toxicity and depressant effects of ethanol in rats

1972 • 22 citations

STUDIES ON TETRAHYDROISOQUINOLINES (THI) (II) PHARMACOLOGICAL ACTION ON CARDIOVASCULAR SYSTEM

1967 • 22 citations

Beta-adrenerge Effekte und ihr zeitlicher Verlauf unter Tetrahydropapaverolin und Isoprenalin am Langendorff-Herzen

1967 • 21 citations

Effects of length of exposure to and concentration of acetaldehyde on the release of catecholamines

1974 • 21 citations

Mechanisms of Stimulus–Secretion Coupling in Adrenal Medulla

1973 • 20 citations

Studies on aldehyde‐protein interactions. I. Reaction of amino acids with lower aldehydes

1954 • 20 citations

SOME TETRAHYDROISOQUINOLINES II. THEIR ACTION ON BLOOD PRESSURE, RESPIRATION AND SMOOTH MUSCLE

1938 • 20 citations

Pharmacological properties of tetrahydropapaveroline and their relation to the catecholamines

1964 • 19 citations

SOME TETRAHYDROISOQUINOLINES I. THEIR RELATIVE TOXICOLOGY AND SYMPTOMATOLOGY

1938 • 19 citations

An analysis of the sympathomimetic activity of 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (TIQ).

1975 • 19 citations

Die Hemmung mechanischer und metabolischer Katecholaminwirkungen durch Isopropylmethoxamin und K� 592 am Herzen

1967 • 18 citations

Pyrogallol potentiates acetaldehyde blood levels during ethanol oxidation in rats

1974 • 18 citations

Effects of inhaled acetaldehyde and propionaldehyde on blood pressure and heart rate

1972 • 18 citations

Evaluation of the optical isomers of tetrahydroisoquinolines in rat adipose tissue and guinea pig aorta

1974 • 18 citations

TETRAHYDROISOQUINOLINE ALKALOIDS FROM CONDENSATION OF ALCOHOL METABOLITES WITH NOREPINEPHRINE: PREPARATIVE SYNTHESIS AND POTENTIAL ANALYSIS IN NERVOUS TISSUE BY GAS CHROMATOGRAPHY

1973 • 17 citations

Inhibition of the Formation of Tetrahydroisoquinoline Alkaloids in Brain Homogenates

1973 • 17 citations

The effect of cysteine in modifying the action of ethanol given chronically in rats

1966 • 15 citations

Response : Alcohol Addiction and Tetrahydropapaveroline

1970 • 15 citations

A method for the induction of dependence to ethanol in mice.

1973 • 13 citations

Augmentation of the Pressor Response to Guanethedine by Inhibition of Catechol O-Methyltransferase

1961 • 12 citations

Pharmacological relationship between aldehydes and arterenol.

1954 • 12 citations

A concept of the etiology of alcoholism.

1965 • 11 citations

Distribution of exogenous acetaldehyde in cow adrenal medulla chromaffin granules

1974 • 11 citations

Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla

1974 • 11 citations

Blockade of hepatic aldehyde dehydrogenase in mice on chronic ingestion of 4-bromopyrazole and 4-iodopyrazole

1975 • 11 citations

Response : Morphine and Ethanol Physical Dependence: A Critique of a Hypothesis

1970 • 10 citations

[Pharmacological study of a possible dopamine metabolite, tetrahydropapaveroline].

1971 • 10 citations

Experimental evidence for calcium independent catecholamine secretion from the bovine adrenal medulla.

1975 • 9 citations

Biotransformation of (+)-Reticuline in Rat

1972 • 9 citations

H. INTRODUCTORY REMARKS

1966 • 9 citations

SOME TETRAHYDROISOQUINOLINES IV. THE CIRCULATORY ADRENOLYTIC EFFECTS

1940 • 7 citations

SOME TETRAHYDROISOQUINOLINES A NOTE ON THE RELATIVE LETHAL AND CIRCULATORY EFFECTS OF SOME 2-ALKYL DERIVATIVES

1940 • 7 citations

SOME TETRAHYDROISOQUINOLINES III. THE RELATIVE ANTIANESTHETIC EFFECTS

1938 • 6 citations

Effects of Adrenal Ligation and Adrenergic Blockade on Pressor Responses to Acetaldehyde in Dogs.

1952 • 5 citations

Evidence for secretory tubules in the adrenal medulla.

1973 • 4 citations

Brain coenzyme A activity in rats chronically ingesting ethanol.

1967 • 3 citations

Response : Ethanol Consumption by Rats under Different Lighting Conditions

1972 • 2 citations

Methanol traces found in alcoholics' blood

1973 • 1 citations