Opioid Peptides Endorphins in Pituitary and Brain

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Purification and properties

1975 • 1,733 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 • 811 citations

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

1976 • 664 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 • 554 citations

Morphine receptors as regulators of adenylate cyclase activity.

1975 • 529 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

C fragment of lipotropin has a high affinity for brain opiate receptors

1976 • 488 citations

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

1971 • 413 citations

Behavioral effects of separate and combined administration of naloxone and d-amphetamine.

1974 • 411 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

1974 • 373 citations

The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α‐ and β‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileum

1970 • 360 citations

Heroin Addiction—A Metabolic Disease

1967 • 338 citations

In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics

1975 • 289 citations

Isolation

1975 • 286 citations

Morphine-like ligand for opiate receptors in human CSF

1975 • 281 citations

Isolation and Amino-acid Sequence of β-LPH from Sheep Pituitary Glands

1965 • 273 citations

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

1976 • 264 citations

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

1975 • 240 citations

Identification of novel high affinity opiate receptor binding in rat brain

1975 • 225 citations

The Opiate Receptor

1974 • 188 citations

ACTH-like peptides and opiate receptors in the rat brain: Structure-activity studies

1975 • 187 citations

Distribution of stereospecific binding of the potent narcotic analgesic etorphine in the human brain: predominance in the limbic system.

1973 • 183 citations

Receptor binding and pharmacological activity of opiates in the guinea-pig intestine.

1975 • 182 citations

Phylogenetic distribution of opiate receptor binding

1974 • 175 citations

Failure of the opiate antagonist naloxone to modify hypnotic analgesia.

1975 • 156 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

Effects of narcotic antagonists on fluid intake in the rat

1975 • 143 citations

Primary structure of human β-lipotropin

1976 • 141 citations

On the role of endogenous opioid peptides: Failure of naloxone to influence shock escape threshold in the rat

1976 • 137 citations

Peptide Hormones

1974 • 121 citations

Influence of opiates on the levels of adenosine 3′ : 5′-cyclic monophosphate in neuroblastoma x glioma hybrid cells

1975 • 115 citations

Effect of the opiate antagonist naloxone on body temperature in rats

1975 • 95 citations

Failure of hypophysectomy to alter brain content of opioid peptides (endorphins)

1976 • 74 citations

[Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].

1976 • 61 citations

Opiate receptors

1974 • 58 citations

Inactivity of narcotic glucuronides as analgesics and on guinea-pig ileum.

1972 • 54 citations

A synthetic peptide with morphine-like pharmacologic action

1975 • 50 citations

In search of the opiate receptor

1973 • 37 citations

The opiate narcotics, neurochemical mechanisms in analgesia and dependence

1976 • 36 citations

Further characterization of morphine-like peptides (endorphins) from pituitary

1976 • 30 citations