The Neural Basis of Ethanol Dependence: is the Withdrawal Reaction Mediated by Localized Changes in Synaptic Excitability?

Statistical principles in experimental design.

1962 • 27,228 citations

The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem

1986 • 4,155 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

Central nervous system mechanisms of analgesia

1976 • 710 citations

Effects of single doses and chronic administration of ethanol on experimental seizures in mice.

1958 • 177 citations

Narcotics and the hypothalamus

1974 • 163 citations

A General Theory of the Genesis of Drug Dependence by Induction of Receptors

1965 • 149 citations

Impairment of shuttle box avoidance learning following prolonged alcohol consumption in rats

1971 • 147 citations

Alcohol withdrawal in mice: Electroencephalographic and behavioral correlates

1974 • 126 citations

Sites of action of morphine involved in the development of physical dependence in rats

1976 • 112 citations

Ethanol dependence in the rat: A parametric analysis

1975 • 101 citations

Another inexpensive headplug for the electrical recording and or stimulation of rats

1972 • 92 citations

INHIBITION OF THE TRANSPORT OF 5‐HYDROXYINDOLEACETIC ACID FROM BRAIN BY ETHANOL¹

1975 • 79 citations

Alcohol withdrawal syndrome in rats: Neural and behavioral correlates

1973 • 74 citations

Persistence of Brain Hyperexcitability Following Chronic Alcohol Exposure in Rats

1977 • 70 citations

XIX. Enzyme expansion theory of drug tolerance and physical dependence.

1968 • 67 citations

The rapid development of physical dependence on barbiturates.

1965 • 67 citations

The startle response in rats: effect of ethanol

1976 • 64 citations

Sound-induced seizures during ethanol withdrawal in mice

1971 • 62 citations

ELECTROENCEPHALOGRAPHIC CHANGES ASSOCIATED WITH CHRONIC ALCOHOLIC INTOXICATION AND THE ALCOHOL ABSTINENCE SYNDROME

1956 • 61 citations

Regional sensitivity of the rat brain to the inhibitory effects of morphine on wet shake behavior.

1975 • 48 citations

Sites of action of morphine involved in the development of physical dependence in rats

1976 • 44 citations

Changes in the neuro-excitability of alcohol-dependent rats undergoing withdrawal as measured by the pentylenetetrazole seizure threshold

1973 • 37 citations

Electrographic and behavioral effects of diazepam during alcohol withdrawal stage in cats

1970 • 34 citations

Regional distribution of ethanol in rat brain

1976 • 27 citations

Electroencephalographic signs of ethanol tolerance and physical dependence in the cat

1975 • 26 citations

Ethanol dependence in the rat: Temporal changes in neuroexcitability following withdrawal

1978 • 21 citations

Sites of action of morphine involved in the development of physical dependence in rats

1977 • 17 citations

A concept of the etiology of alcoholism.

1965 • 11 citations