Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

2000 • 796 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 • 555 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer

1999 • 264 citations

Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1

2001 • 263 citations

Applications of peptide arrays prepared by the SPOT-technology

2001 • 250 citations

Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors

1999 • 250 citations

ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

2000 • 234 citations

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

2000 • 219 citations

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

2000 • 216 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

2001 • 180 citations

A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission

2001 • 179 citations

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

1999 • 179 citations

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors

2002 • 173 citations

Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

1996 • 164 citations

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

1998 • 158 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3

2001 • 142 citations

Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP)

1999 • 137 citations

Identification of a Cytoplasmic-Retention Sequence in ERK2

1999 • 136 citations

The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases

2001 • 135 citations

Measurement of kinase activation in single mammalian cells

2000 • 134 citations

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm

1999 • 129 citations

Regulation of MAP kinases by docking domains

2001 • 127 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 127 citations

Protein modification: Docking sites for kinases

1999 • 124 citations

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2

2001 • 115 citations

Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3

2001 • 113 citations

Discordance between the Binding Affinity of Mitogen-activated Protein Kinase Subfamily Members for MAP Kinase Phosphatase-2 and Their Ability to Activate the Phosphatase Catalytically

2001 • 109 citations

Regulation of MAPK Function by Direct Interaction with the Mating-Specific Gα in Yeast

2002 • 101 citations

Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

2002 • 98 citations

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

2003 • 97 citations

Selective Targeting of MAPKs to the ETS Domain Transcription Factor SAP-1

2001 • 91 citations

Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking

2001 • 86 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 86 citations

Involvement of the Activation Loop of ERK in the Detachment from Cytosolic Anchoring

2001 • 80 citations

Modular Structure of a Docking Surface on MAPK Phosphatases

2002 • 74 citations

Extracellular Signal-Regulated Kinase Binds to TFII-I and Regulates Its Activation of the c-fosPromoter

2000 • 59 citations

Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2

2001 • 59 citations

A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

1999 • 57 citations

Altered Regulation of ERK1b by MEK1 and PTP-SL and Modified Elk1 Phosphorylation by ERK1b Are Caused by Abrogation of the Regulatory C-terminal Sequence of ERKs

2001 • 47 citations

Two Clusters of Residues at the Docking Groove of Mitogen-activated Protein Kinases Differentially Mediate Their Functional Interaction with the Tyrosine Phosphatases PTP-SL and STEP

2002 • 33 citations

Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase

1999 • 19 citations

Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs.

2017 • 2 citations