War and peace at mucosal surfaces

Neutrophil Extracellular Traps Kill Bacteria

2004 • 8,690 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

2004 • 4,044 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants

1998 • 2,394 citations

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

2003 • 2,325 citations

Decoding the Patterns of Self and Nonself by the Innate Immune System

2002 • 2,096 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

H<scp>OW</scp>H<scp>OST</scp>-M<scp>ICROBIAL</scp>I<scp>NTERACTIONS</scp>S<scp>HAPE THE</scp>N<scp>UTRIENT</scp>E<scp>NVIRONMENT OF THE</scp>M<scp>AMMALIAN</scp>I<scp>NTESTINE</scp>

2002 • 1,558 citations

Interactions between commensal intestinal bacteria and the immune system

2004 • 1,540 citations

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

2003 • 1,527 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 • 1,305 citations

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

2003 • 1,265 citations

Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion

2000 • 1,261 citations

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

2002 • 1,224 citations

The indigenous gastrointestinal microflora

1996 • 1,149 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

2003 • 983 citations

Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens

2004 • 947 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

2000 • 837 citations

Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci

1991 • 823 citations

A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response

1999 • 756 citations

Involvement of a plasmid in the invasive ability of Shigella flexneri

1982 • 733 citations

Bacterial flagellin is a dominant antigen in Crohn disease

2004 • 698 citations

Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide

2001 • 672 citations

Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes

1999 • 669 citations

Bacterial flagellin is a dominant antigen in Crohn disease

2004 • 666 citations

Defensins of vertebrate animals

2002 • 659 citations

Epithelial cells as sensors for microbial infection.

1997 • 623 citations

A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier

2001 • 609 citations

Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.

1999 • 602 citations

Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages

1998 • 596 citations

CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

2001 • 588 citations

An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

2000 • 535 citations

Crohn’s disease and the NOD2 gene: a role for paneth cells

2003 • 528 citations

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

1997 • 524 citations

Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium

1999 • 496 citations

Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.

1993 • 460 citations

Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer

2001 • 451 citations

The Yersinia Ysc–Yop 'Type III' weaponry

2002 • 427 citations

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.

1991 • 425 citations

Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator

2001 • 425 citations

Structure, function, and membrane integration of defensins

1995 • 423 citations

Molecular Basis of the Interaction ofSalmonellawith the Intestinal Mucosa

1999 • 422 citations

Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells

2002 • 414 citations

Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

1998 • 407 citations

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

2001 • 393 citations

Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation

2000 • 388 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells

2001 • 354 citations

Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut

2003 • 353 citations

Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein

1995 • 342 citations

Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway

1999 • 328 citations

Intestinal Macrophages Lack CD14 and CD89 and Consequently Are Down-Regulated for LPS- and IgA-Mediated Activities

2001 • 319 citations

Cathelicidins: a family of endogenous antimicrobial peptides

2002 • 318 citations

Neutrophil elastase targets virulence factors of enterobacteria

2002 • 314 citations

DNA from probiotic bacteria modulates murine and human epithelial and immune function

2004 • 314 citations

Discrimination Between Intracellular Uptake and Surface Adhesion of Bacterial Pathogens

1991 • 302 citations

Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.

1994 • 289 citations

The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches.

1996 • 283 citations

Dendritic Cells Shuttle Microbes Across Gut Epithelial Monolayers

2001 • 279 citations

Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88

2002 • 275 citations

M cells as ports of entry for enteroinvasive pathogens: Mechanisms of interaction, consequences for the disease process

1999 • 263 citations

Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine.

1980 • 262 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice

1969 • 243 citations

The rab7 GTPase controls the maturation of Salmonella typhimurium-containing vacuoles in HeLa cells

1999 • 234 citations

Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model

2000 • 218 citations

Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer's patch intestinal epithelium

1997 • 216 citations

Interleukin-8 Controls Bacterial Transepithelial Translocation at the Cost of Epithelial Destruction in Experimental Shigellosis

1999 • 211 citations

Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri.

1994 • 207 citations

Apical Secretion of a Pathogen-Elicited Epithelial Chemoattractant Activity in Response to Surface Colonization of Intestinal Epithelia by Salmonella typhimurium

1998 • 203 citations

Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures

1996 • 193 citations

Pathology of the Gastrointestinal Tract

1999 • 192 citations

SseG, a virulence protein that targets Salmonella to the Golgi network

2003 • 184 citations

Host-Pathogen Interactions: Subversion and Utilization of the NF-κB Pathway during Infection

2002 • 180 citations

Infection of rabbit Peyer's patches by Shigella flexneri: effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium

1996 • 179 citations

Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5

2003 • 174 citations

In vivo apoptosis in Shigella flexneri infections

1996 • 173 citations

Identification of hepoxilin A₃in inflammatory events: A required role in neutrophil migration across intestinal epithelia

2004 • 169 citations

IL-8 Is a Key Chemokine Regulating Neutrophil Recruitment in a New Mouse Model ofShigella-Induced Colitis

2004 • 164 citations

Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches— a personal and historical perspective

1999 • 164 citations

Anti-Inflammatory Role for Intracellular Dimeric Immunoglobulin A by Neutralization of Lipopolysaccharide in Epithelial Cells

2003 • 161 citations

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing

2003 • 160 citations

Structural characterization of the lipid A component of Bacteroides fragilis strain NCTC 9343 lipopolysaccharide

1989 • 155 citations

Rupture, invasion and inflammatory destruction of the intestinal barrier byShigella, making sense of prokaryote–eukaryote cross-talks

2001 • 153 citations

Absence of Toll-Like Receptor 4 Explains Endotoxin Hyporesponsiveness in Human Intestinal Epithelium

2001 • 152 citations

Trafficking of the Salmonella Vacuole in Macrophages

2002 • 150 citations

Paneth Cell Defensins and Innate Immunity of the Small Bowel

2001 • 141 citations

Comprehensive Study of the Intestinal Stage of Listeriosis in a Rat Ligated Ileal Loop System

1998 • 139 citations

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

1995 • 136 citations

Colonization of the streptomycin-treated mouse large intestine by a human fecal Escherichia coli strain: role of growth in mucus

1988 • 132 citations

Experimental bacillary dysentery. An electron microscopic study of the response of the intestinal mucosa to bacterial invasion.

1965 • 128 citations

How the gut senses its content

2002 • 126 citations

Interaction of Yersinia enterocolitica with epithelial cells: invasin beyond invasion

2003 • 98 citations

An Essential Role for Gamma Interferon in Innate Resistance toShigella flexneriInfection

1998 • 96 citations

Listeriolysin O activates mitogen-activated protein kinase in eucaryotic cells

1996 • 83 citations

Structure and function of the intestinal epithelial barrier in health and disease.

1990 • 70 citations

Microbial Pathogenesis and the Intestinal Epithelial Cell

2003 • 58 citations

Purification and Characterization of the Mucinase of Vibrio cholerae

1982 • 58 citations

Apoptosis in Acute Shigellosis Is Associated with Increased Production of Fas/Fas Ligand, Perforin, Caspase-1, and Caspase-3 but Reduced Production of Bcl-2 and Interleukin-2

2002 • 57 citations

Immune responses

2004 • 56 citations

Ultrastructural study of M cells from colonic lymphoid nodules obtained by colonoscopic biopsy

1992 • 56 citations

Immunity toSalmonellafrom a dendritic point of view

2003 • 49 citations

Pathology of the Gastrointestinal Tract

1993 • 45 citations

The ShiA protein encoded by theShigella flexneriSHI-2 pathogenicity island attenuates inflammation

2003 • 40 citations

Salmonella entry into mammalian cells: different yet converging signal transduction pathways?

1994 • 32 citations

Introduction: Regulation of T cell development by the thymic microenvironment

1999 • 13 citations

Molecular infection biology : interactions between microorganisms and cells

2002 • 12 citations

Salmonellaspp.: Masters of Inflammation

2014 • 4 citations

Role of Intestinal M Cells in Microbial Pathogenesis

2014 • 2 citations

How Noninvasive Pathogens Induce Disease: Lessons from Enteropathogenic and Enterohemorrhagic Escherichia Coli

2014 • 2 citations

Effector Molecules ofShigellaPathogenesis and Host Responses

2014 • 2 citations