Rupture, invasion and inflammatory destruction of the intestinal barrier byShigella, making sense of prokaryote–eukaryote cross-talks

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Global burden of Shigella infections: implications for vaccine development and implementation of control strategies.

1999 • 1,261 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

1999 • 968 citations

Supramolecular Structure of the Salmonella typhimurium Type III Protein Secretion System

1998 • 872 citations

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 • 804 citations

Involvement of a plasmid in the invasive ability of Shigella flexneri

1982 • 733 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility

1999 • 513 citations

The Tripartite Type III Secreton of Shigella flexneri Inserts Ipab and Ipac into Host Membranes

1999 • 487 citations

“Black holes” and bacterial pathogenicity: A large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli

1998 • 431 citations

Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

1998 • 407 citations

A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

1996 • 405 citations

Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation

2000 • 388 citations

The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri

2000 • 372 citations

Structure and composition of the Shigella flexneri‘needle complex’, a part of its type III secreton

2001 • 343 citations

A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a

1986 • 312 citations

Alterations in the pathogenicity of Escherichia coli K-12 after transfer of plasmid and chromosomal genes from Shigella flexneri

1983 • 299 citations

Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.

1994 • 289 citations

M cells as ports of entry for enteroinvasive pathogens: Mechanisms of interaction, consequences for the disease process

1999 • 263 citations

Identification of a chromosomal gene controlling temperature-regulated expression of Shigella virulence.

1988 • 255 citations

IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells

1999 • 251 citations

InvasiveShigella flexneriActivates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells

2000 • 249 citations

INTRACELLULAR PATHOGENS AND THE ACTIN CYTOSKELETON

1998 • 248 citations

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

IpaB mediates macrophage apoptosis induced by Shigella flexneri

1994 • 228 citations

Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

1998 • 224 citations

Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin

1997 • 218 citations

Interleukin-8 Controls Bacterial Transepithelial Translocation at the Cost of Epithelial Destruction in Experimental Shigellosis

1999 • 211 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

Apoptosis as a proinflammatory event: What can we learn from bacteria-induced cell death?

1997 • 187 citations

Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway.

1995 • 181 citations

Infection of rabbit Peyer's patches by Shigella flexneri: effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium

1996 • 179 citations

Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells.

1995 • 174 citations

Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization

1999 • 158 citations

SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri

1997 • 152 citations

Rho-dependent membrane folding causes Shigella entry into epithelial cells.

1996 • 141 citations

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

1995 • 136 citations

Genetic and Molecular Basis of Epithelial Cell Invasion by Shigella Species

1991 • 132 citations

ICE/CED-3 proteasesin apoptosis

1996 • 128 citations

Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility

1999 • 127 citations

Studying M cells and their role in infection

1998 • 127 citations

The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri

1999 • 119 citations

Plasmid-mediated early killing of eucaryotic cells by Shigella flexneri as studied by infection of J774 macrophages

1987 • 104 citations

An Essential Role for Gamma Interferon in Innate Resistance toShigella flexneriInfection

1998 • 96 citations

A system for identifying post‐invasion functions of invasion genes: requirements for the Mxi–Spa type III secretion pathway of Shigella flexneri in intercellular dissemination

1999 • 95 citations

Functional Analysis of Shigella VirG Domains Essential for Interaction with Vinculin and Actin-based Motility

1996 • 93 citations

Gene Targeting Studies Begin to Reveal the Function of Neurofilament Proteins

1998 • 88 citations

M Cells in Antigen Sampling in Mucosal Tissues

1999 • 87 citations

Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed

1997 • 72 citations

A functional role for ezrin during Shigella flexneri entry into epithelial cells

1999 • 63 citations

SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity

1998 • 59 citations

Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation

2000 • 59 citations

Interferon α Inhibits a Src-mediated Pathway Necessary for Shigella-induced Cytoskeletal Rearrangements in Epithelial Cells

1998 • 55 citations

The development of a FACS‐based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spread

2000 • 55 citations

Blockade of CD14 Increases Shigella-Mediated Invasion and Tissue Destruction

2000 • 44 citations

Increased Interleukin-1 (IL-1) and Imbalance between IL-1 and IL-1 Receptor Antagonist during Acute Inflammation in Experimental Shigellosis

1999 • 42 citations

Characterization of the interaction of IpaB and IpaD, proteins required for entry of Shigella flexneri into epithelial cells, with a lipid membrane

2000 • 39 citations

Microbial-Host Interactions at Mucosal Sites. Host Response to Pathogenic Bacteria at Mucosal Sites

1999 • 38 citations

Myosin light chain kinase plays an essential role in S. flexneri dissemination

2000 • 37 citations

A systemic downregulation of gamma interferon production is associated with acute shigellosis

1997 • 27 citations

Slaying the Hydra all at once or head by head?

1998 • 22 citations

A pot‐pourri of plasmid paradoxes: effects of a second copy

2000 • 21 citations

Induction of adherence and degranulation of polymorphonuclear leukocytes: a new expression of the invasive phenotype of Shigella flexneri

1996 • 19 citations

Vaccines against Enteric Infections

2015 • 15 citations