Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

The PPARs: From Orphan Receptors to Drug Discovery

2000 • 1,792 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

2001 • 1,062 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response

1999 • 756 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

1997 • 697 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

The role of PPAR-γ in macrophage differentiation and cholesterol uptake

2001 • 507 citations

Peroxisome proliterator-activated receptors, orphans with ligands and functions

1997 • 494 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease

1989 • 433 citations

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

1997 • 422 citations

Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase

1999 • 399 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

Inflammatory alterations in mesenteric adipose tissue in Crohn's disease

1999 • 336 citations

Thiazolidinediones: an update

2000 • 230 citations

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

1997 • 228 citations

Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor α production in trinitrobenzene sulphonic acid induced colitis

1997 • 222 citations

JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

1998 • 217 citations

MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α

1996 • 197 citations

An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer

1999 • 197 citations

Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation

1998 • 196 citations

Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells

1999 • 168 citations

Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation

1996 • 166 citations

Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival

1999 • 135 citations

The mechanism of altered neural function in a rat model of acute colitis

1997 • 113 citations

Cell Stress and MKK6b-mediated p38 MAP Kinase Activation Inhibit Tumor Necrosis Factor-induced IκB Phosphorylation and NF-κB Activation

1999 • 101 citations

Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in rats

1995 • 101 citations

Equine Herpesvirus-2 E10 Gene Product, but Not Its Cellular Homologue, Activates NF-κB Transcription Factor and c-Jun N-terminal Kinase

1999 • 101 citations

Tumor necrosis factor alpha-mediated inhibition of melanogenesis is dependent on nuclear factor kappa B activation

1999 • 72 citations

Vanadate Induction of NF-κB Involves IκB Kinase β and SAPK/ERK Kinase 1 in Macrophages

1999 • 67 citations

TRAF2 plays a dual role in NF‐κB‐dependent gene activation by mediating the TNF‐induced activation of p38 MAPK and IκB kinase pathways

1998 • 67 citations

Glutamine depletion and increased gut permeability in nonanorectic, non-weight-losing tumor-bearing rats

1997 • 63 citations

Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation

1998 • 40 citations

Non-lymphoid and lymphoid cells in acute, chronic and relapsing experimental colitis

1995 • 39 citations

Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase.

1998 • 33 citations

MECHANISM AND PREVENTION OF CHRONIC COLONIC INFLAMMATION WITH TRINITROBENZENE SULFONIC ACID IN RATS

1992 • 30 citations

Urinary 8-Hydroxydeoxyguanosine Excretion as a Non-Invasive Marker of Neutrophil Activation in Animal Models of Inflammatory Bowel Disease

1998 • 23 citations

Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells

1997 • 20 citations

Effects of local budesonide treatment on the cell-mediated immune response in acute and relapsing colitis in rats.

1998 • 15 citations

Chronic intrajejunal TNBS application in TNBS-sensitized rats: A new model of chronic inflammatory bowel diseases

1992 • 11 citations