Defensins of vertebrate animals

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

2001 • 1,295 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

2000 • 1,002 citations

Inactivation of the dlt Operon inStaphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides

1999 • 955 citations

The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations

2000 • 740 citations

Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with <scp>l</scp>-Lysine

2001 • 736 citations

A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

1999 • 686 citations

Plant defense peptides

1998 • 522 citations

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

2000 • 489 citations

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

1999 • 467 citations

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

2001 • 465 citations

Human beta-defensin-2

1999 • 437 citations

Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity

2001 • 384 citations

The Structure of Human β-Defensin-2 Shows Evidence of Higher Order Oligomerization

2000 • 315 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

Antibacterial peptides isolated from insects

2000 • 278 citations

Discovery of new human β-defensins using a genomics-based approach

2001 • 249 citations

An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats

2001 • 236 citations

Mouse neutrophils lack defensins

1992 • 223 citations

Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells.

2000 • 208 citations

Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens

2000 • 193 citations

Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes II. Composition, Properties, and Mechanism of Antibacterial Action

1966 • 191 citations

The Structure of Human β-Defensin-1

2001 • 186 citations

Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs

1999 • 183 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 180 citations

Bacterial Exposure Induces and Activates Matrilysin in Mucosal Epithelial Cells

2000 • 174 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 152 citations

Dermatan sulphate is released by proteinases of common pathogenic bacteria and inactivates antibacterial α‐defensin

2001 • 152 citations

Gallinacin-3, an Inducible Epithelial β-Defensin in the Chicken

2001 • 151 citations

Protein splicing and autoproteolysis mechanisms

1997 • 148 citations

Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds

2001 • 145 citations

Solution Structure of Bovine Neutrophil .beta.-Defensin-12: The Peptide Fold of the .beta.-Defensins Is Identical to That of the Classical Defensins

1995 • 142 citations

Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes I. Resolution of Antibacterial and Enzymatic Activities

1966 • 142 citations

Paneth Cell Defensins and Innate Immunity of the Small Bowel

2001 • 141 citations

Germ-free and Colonized Mice Generate the Same Products from Enteric Prodefensins

2000 • 131 citations

The NMR Structure of Human β-Defensin-2 Reveals a Novel α-Helical Segment^,

2001 • 119 citations

An essential amino acid induces epithelial β-defensin expression

2000 • 113 citations

Circular minidefensins and posttranslational generation of molecular diversity

2001 • 113 citations

Porcine Epithelial β-Defensin 1 Is Expressed in the Dorsal Tongue at Antimicrobial Concentrations

1999 • 108 citations

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3

1997 • 107 citations

Abundant human β-defensin-1 expression in milk and mammary gland epithelium

2001 • 91 citations

Mouse beta defensin-1 is a functional homolog of human beta defensin-1

1998 • 89 citations

NMR Solution Structure of Murine CCL20/MIP-3α, a Chemokine That Specifically Chemoattracts Immature Dendritic Cells and Lymphocytes through Its Highly Specific Interaction with the β-Chemokine Receptor CCR6

2001 • 85 citations

A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide

1999 • 84 citations

A Novel Murine β-Defensin Expressed in Tongue, Esophagus, and Trachea

2000 • 77 citations

β-Defensin Expression in Human Mammary Gland Epithelia

2000 • 72 citations

Structural Analysis of Human β-Defensin-1 and Its Significance in Urinary Tract Infection

2000 • 69 citations

Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold

2000 • 59 citations

Inhibition of hBD-3, but Not hBD-1 and hBD-2, mRNA Expression by Corticosteroids

2001 • 59 citations

Organization of the Human Gene Encoding the Epididymis-Specific EP2 Protein Variants and Its Relationship to Defensin Genes1

2001 • 51 citations

A Novel Mouse β-Defensin, mBD-6, Predominantly Expressed in Skeletal Muscle

2001 • 31 citations

Three-Dimensional Structure of RK-1: A Novel α-Defensin Peptide

2000 • 30 citations