The ShiA protein encoded by theShigella flexneriSHI-2 pathogenicity island attenuates inflammation

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative Bacteria

1983 • 7,336 citations

Global burden of Shigella infections: implications for vaccine development and implementation of control strategies.

1999 • 1,261 citations

Construction of versatile low-copy-number vectors for cloning, sequencing and gene expression in Escherichia coli

1991 • 1,170 citations

Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector

1991 • 1,062 citations

Involvement of a plasmid in the invasive ability of Shigella flexneri

1982 • 733 citations

Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

1998 • 407 citations

A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

1996 • 405 citations

Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation

2000 • 388 citations

The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD.

1994 • 362 citations

Alterations in the pathogenicity of Escherichia coli K-12 after transfer of plasmid and chromosomal genes from Shigella flexneri

1983 • 299 citations

Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.

1994 • 289 citations

Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication

1988 • 278 citations

Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis

1989 • 272 citations

M cells as ports of entry for enteroinvasive pathogens: Mechanisms of interaction, consequences for the disease process

1999 • 263 citations

IpaB mediates macrophage apoptosis induced by Shigella flexneri

1994 • 228 citations

Interleukin-8 Controls Bacterial Transepithelial Translocation at the Cost of Epithelial Destruction in Experimental Shigellosis

1999 • 211 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri.

1994 • 207 citations

MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins

1992 • 172 citations

New plasmids carrying antibiotic-resistance cassettes

1995 • 156 citations

The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages

1997 • 154 citations

The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island

1999 • 147 citations

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

1995 • 136 citations

The selC‐associated SHI‐2 pathogenicity island of Shigella flexneri

1999 • 135 citations

Indomethacin Inhibition of Salmonella typhimurium, Shigella flexneri, and Cholera-Mediated Rabbit Ileal Secretion

1974 • 120 citations

Virulence of iron transport mutants of Shigella flexneri and utilization of host iron compounds

1987 • 111 citations

VIRULENCE OFESCHERICHIA-SHIGELLAGENETIC HYBRIDS FOR THE GUINEA PIG

1963 • 97 citations

Evaluation with an iuc::Tn10 mutant of the role of aerobactin production in the virulence of Shigella flexneri

1987 • 96 citations

Rectal Histology in Acute Bacillary Dysentery

1986 • 93 citations

Congo red binding and salt aggregation as indicators of virulence in Shigella species

1988 • 92 citations

Genetic Determinants of Shigella Pathogenicity

1988 • 85 citations

Molecular and Cellular Biology of Shigella flexneri Invasiveness: From Cell Assay Systems to Shigellosis

1992 • 76 citations

Simple microcomputer system for mapping tissue sections with the light microscope

1988 • 73 citations

Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed

1997 • 72 citations

Immune cells associated with M cells in the follicle-associated epithelium of Peyer's patches in the rat

1989 • 65 citations

Release of Toll-Like Receptor-2-Activating Bacterial Lipoproteins inShigella flexneriCulture Supernatants

2001 • 44 citations

Pathogenicity Islands of Shigella

2002 • 40 citations

Molecular and Cellular Mechanisms of Tissue Invasion by Shigella flexneria

1994 • 39 citations

The use of mice in the Sereny test as a virulence assay of shigellae and enteroinvasive Escherichia coli

1986 • 38 citations

The localization of macrophage subsets and dendritic cells in the gastrointestinal tract of the mouse with special reference to the presence of high endothelial venules

1990 • 37 citations