A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

Coupling of Hormonal Stimulation and Transcription via the Cyclic AMP-Responsive Factor CREB Is Rate Limited by Nuclear Entry of Protein Kinase A

1993 • 426 citations

Heterodimer formation between CREB and JUN proteins.

1990 • 347 citations

Galectins and cancer

2002 • 344 citations

The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses

2003 • 248 citations

The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3β and cAMP-responsive Element-binding Protein-dependent Pathways

2000 • 243 citations

Cell Cycle Regulation of Cyclin A Gene Expression by the Cyclic AMP-Responsive Transcription Factors CREB and CREM

1995 • 233 citations

pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

1999 • 227 citations

All Roads Lead to ATF4

2003 • 185 citations

Endothelin-1: a multifunctional molecule in cancer

2003 • 179 citations

p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells

2003 • 175 citations

Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressers

1993 • 169 citations

Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription

1993 • 166 citations

Imaging Transgene Expression in Live Animals

2001 • 162 citations

Role of the PKA‐Regulated Transcription Factor CREB in Development and Tumorigenesis of Endocrine Tissues

2002 • 158 citations

Adrenomedullin and cancer

2003 • 153 citations

Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells

2002 • 143 citations

CREB-Mediated Transcriptional Control

1999 • 143 citations

Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide

1999 • 125 citations

Redox Regulation of cAMP-responsive Element-binding Protein and Induction of Manganous Superoxide Dismutase in Nerve Growth Factor-dependent Cell Survival

2003 • 124 citations

The CREB family of activators is required for endochondral bone development

2001 • 123 citations

Analysis of the Structural Properties of cAMP-responsive Element-binding Protein (CREB) and Phosphorylated CREB

1996 • 117 citations

In vivo prediction of vascular susceptibility to vascular susceptibility endothelial growth factor withdrawal: magnetic resonance imaging of C6 rat glioma in nude mice.

1999 • 114 citations

PTHrP Modulates Chondrocyte Differentiation through AP-1 and CREB Signaling

2001 • 113 citations

Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells

2003 • 103 citations

Stimulation of Endothelin B Receptors in Astrocytes Induces cAMP Response Element-Binding Protein Phosphorylation andc-fosExpression Via Multiple Mitogen-Activated Protein Kinase Signaling Pathways

2001 • 92 citations

Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging

1998 • 83 citations

Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family

2000 • 80 citations

Vascular Endothelial Cell Growth Factor Activates CRE-binding Protein by Signaling through the KDR Receptor Tyrosine Kinase

2001 • 80 citations

The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells

2001 • 79 citations

Sustained Induction of ERK, Protein Kinase B, and p70 S6 Kinase Regulates Cell Spreading and Formation of F-actin Microspikes Upon Ligation of Integrins by Galectin-8, a Mammalian Lectin

2003 • 75 citations

Regulation of Pdha-2 Expression Is Mediated by Proximal Promoter Sequences and CpG Methylation

1997 • 63 citations

Two cysteine residues in the DNA-binding domain of CREB control binding to CRE and CREB-mediated gene expression

2001 • 44 citations

Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia

2002 • 38 citations

Angiogenic Protein Cyr61 is Expressed by Podocytes in Anti-Thy-1 Glomerulonephritis

2003 • 36 citations

Targeting the ATF-1/CREB Transcription Factors by Single Chain Fv Fragment in Human Melanoma: Potential Modality for Cancer Therapy

2001 • 33 citations

cAMP PATHWAY ALTERATIONS FROM THE CELL SURFACE TO THE NUCLEUS IN ADRENOCORTICAL TUMORS

2002 • 29 citations

A genomic-scale view of the cAMP response element-enhancer decoy: A tumor target-based genetic tool

2002 • 26 citations

CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth.

2000 • 24 citations

Gene Regulation Mediated by Interaction between HTLV-1 Promoter Elements and Transcription Factors Tax and CREB

1999 • 8 citations

CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth

2000 • 4 citations

Deleted Work

1955 • 0 citations