A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

The hepatitis B virus

1985 • 1,219 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

1983 • 426 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements

1991 • 224 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

MOLECULAR EVENTS IN THE PATHOGENESIS OF HEPADNAVIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA

1994 • 176 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus

1984 • 155 citations

trans-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

1989 • 145 citations

Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues.

1990 • 140 citations

Activation of Protooncogene C-jun by the X Protein of Hepatitis B Virus

1993 • 123 citations

Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.

1994 • 122 citations

The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase

1990 • 121 citations

Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cMYC protooncogene at the transcriptional level

1991 • 120 citations

Identification of three essential regions of hepatitis B virus X protein for trans-activation function.

1992 • 99 citations

Activation of class I major histocompatibility complex gene expression by hepatitis B virus

1990 • 78 citations

Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2

1990 • 77 citations

Trans-Activation of Epidermal Growth Factor Receptor Gene by the Hepatitis B Virus X-Gene Product

1993 • 71 citations

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

1990 • 69 citations

The hepatitis B virus (HBV) pX transactivates the c-fos promoter through multiple cis-acting elements.

1993 • 69 citations

Effect of X Protein on Transactivation of Hepatitis B Virus Promoters and on Viral Replication

1993 • 68 citations

“Silent” Hepatitis B Virus Mutants Are Responsible for Non‐A, Non‐B, Non‐C, Non‐D, Non‐E Hepatitis

1994 • 59 citations

Two-Codon Insertion Mutations of the HBx Define Two Separate Regions Necessary for Its Trans-activation Function

1993 • 58 citations

Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.

1994 • 52 citations

Detection of a hepatitis B virus variant with a truncated X gene and enhancer II

1992 • 47 citations

Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.

1992 • 45 citations

An internal domain of the hepatitis B virus X antigen is necessary for transactivating activity

1991 • 40 citations

The X Protein of Hepatitis B Virus Has a ribo/deoxy ATPase Activity

1994 • 37 citations

Hepatitis B virus X protein produced in Escherichia coli is biologically functional

1990 • 31 citations

Characteristics of the X gene of hepatitis B virus

1988 • 28 citations

The 17 kDa HBx protein encoded by hepatitis B virus interacts with the activation domains of Oct-1, and functions as a coactivator in the activation and repression of a human U6 promoter.

1993 • 28 citations

Assignment of Disulfide Bonds in the X Protein (HBx) of Hepatitis B Virus

1995 • 26 citations

Functional Analysis of Hepatitis B Virus Transactivator X: Implication of the Leucine Zipper-like Region and C-Terminal Seven Conserved Amino Acids in Functional Regions

1993 • 24 citations

Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator

1991 • 15 citations

The X-gene of human hepatitis B virus transactivates the c-jun and ?-fetoprotein genes

1994 • 15 citations

Nucleotide sequence of the woodchuck hepatitis virus surface antigen mRNAs and the variability of three overlapping viral genes

1986 • 5 citations