The biochemical basis of the NADPH oxidase of phagocytes

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Atomic Structure of Ferredoxin-NADP ⁺ Reductase: Prototype for a Structurally Novel Flavoenzyme Family

1991 • 532 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b−245

1987 • 292 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 290 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.

1989 • 286 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Functional activity of enucleated human polymorphonuclear leukocytes.

1983 • 230 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 210 citations

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

1991 • 195 citations

A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs

1992 • 164 citations

Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.

1992 • 120 citations

The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559.

1991 • 106 citations

Resonance Raman and electron paramagnetic resonance structural investigations of neutrophil cytochrome b558

1991 • 84 citations

Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.

1991 • 78 citations

The target sets the tempo

1992 • 72 citations

Purification and some properties of the small subunit of cytochrome b558 from human neutrophils

1989 • 53 citations

Identification of the haem-binding subunit of cytochrome b−245

1989 • 49 citations

Okadaic acid produces changes in phosphorylation and translocation of proteins and in intracellular calcium in human neutrophils. Relationship with the activation of the NADPH oxidase by different stimuli

1992 • 43 citations

Stabilization of the superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide

1989 • 25 citations