Voltage-activated hydrogen ion currents

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

A Theory of Water and Ionic Solution, with Particular Reference to Hydrogen and Hydroxyl Ions

1933 • 3,085 citations

Intracellular pH.

1981 • 2,440 citations

The action of calcium on the electrical properties of squid axons

1957 • 1,853 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

Influenza virus M2 protein has ion channel activity

1992 • 1,205 citations

Amiloride and its analogs as tools in the study of ion transport

1988 • 1,131 citations

STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS

1995 • 941 citations

Ion transfer across lipid membranes in the presence of gramicidin A

1972 • 828 citations

Electrostatic Potentials at Membrane-Solution Interfaces

1977 • 822 citations

Potassium channels as multi-ion single-file pores.

1978 • 816 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

The after‐effects of impulses in the giant nerve fibres of Loligo

1956 • 748 citations

Liquid junction potentials and small cell effects in patch-clamp analysis

1991 • 681 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

Synthetic Amphiphilic Peptide Models for Protein Ion Channels

1988 • 593 citations

Molecular mechanisms for proton transport in membranes.

1978 • 566 citations

Self-dissociation and protonic charge transport in water and

1958 • 553 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.

1987 • 495 citations

Effects of unstirred layers on membrane phenomena.

1984 • 451 citations

Ion transfer across lipid membranes in the presence of gramicidin A

1972 • 427 citations

Inactivation of the Potassium Conductance and Related Phenomena Caused by Quaternary Ammonium Ion Injection in Squid Axons

1969 • 427 citations

The anomalous rectification and cation selectivity of the membrane of a starfish egg cell

1974 • 394 citations

Transport of protons across membranes by weak acids.

1980 • 391 citations

Hydrogen bonded chain mechanisms for proton conduction and proton pumping

1983 • 381 citations

Potassium Ion Current in the Squid Giant Axon

1960 • 375 citations

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel

1987 • 335 citations

Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones

1982 • 316 citations

Electrogenic Ion Pumps

1982 • 314 citations

Unpacking the incoming influenza virus

1992 • 312 citations

The MotA protein of E. coli is a proton-conducting component of the flagellar motor

1990 • 309 citations

The nature of the voltage-dependent conductance induced by alamethicin in black lipid membranes

1973 • 301 citations

Proton Conductance and the Existence of the H3O· Ion

1956 • 274 citations

Transport of H+ and of ionic weak acids and bases

1983 • 271 citations

The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers

1992 • 235 citations

SURFACE CHARGES AND ION CHANNEL FUNCTION

1991 • 234 citations

Anionic lipid headgroups as a proton-conducting pathway along the surface of membranes: a hypothesis.

1983 • 223 citations

The proton conducting F0-part of bacterial ATP synthases

1984 • 223 citations

Synthetic peptides as models for ion channel proteins

1993 • 211 citations

Ultrastructure, Pharmacologic Inhibition, and Transport Selectivity of Aquaporin CHIP in Proteoliposomes

1994 • 206 citations

Divalent cations and the activation kinetics of potassium channels in squid giant axons.

1982 • 205 citations

Diffusion of Weak Acids across Lipid Bilayer Membranes: Effects of Chemical Reactions in the Unstirred Layers

1973 • 204 citations

Slow changes in potassium permeability in skeletal muscle

1970 • 200 citations

Effects of Intracellular H+ on the Electrical Properties of Excitable Cells

1984 • 198 citations

Channel-Like Function of the Na,K Pump Probed at Microsecond Resolution in Giant Membrane Patches

1994 • 197 citations

The Deduction of Reaction Mechanisms from the Theory of Absolute Rates

1937 • 195 citations

Number of water molecules coupled to the transport of sodium, potassium and hydrogen ions via gramicidin, nonactin or valinomycin

1978 • 191 citations

Extracellular Access to the Na,K Pump: Pathway Similar to Ion Channel

1993 • 182 citations

Internal pH changes associated with the activity of NADPH oxidase of human neutrophils. Further evidence for the presence of an H+ conducting channel

1988 • 178 citations

Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transduction.

1992 • 174 citations

Rapidly activating hydrogen ion currents in perfused neurones of the snail, Lymnaea stagnalis.

1984 • 173 citations

Mechanisms and Consequences of pH-Mediated Cell Regulation

1986 • 172 citations

Structure and function of voltage-gated ion channels

1993 • 171 citations

Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils

1993 • 170 citations

Intracellular pH Regulation in Epithelial Cells

1986 • 167 citations

Proton flux mechanisms in model and biological membranes

1989 • 156 citations

Bacterial adenosine 5'-triphosphate synthase (F1F0): purification and reconstitution of F0 complexes and biochemical and functional characterization of their subunits

1987 • 155 citations

Regulation of intracellular pH in human neutrophils.

1985 • 152 citations

Ion movement through gramicidin A channels. Studies on the diffusion-controlled association step

1983 • 150 citations

The role of fixed and mobile buffers in the kinetics of proton movement

1987 • 148 citations

Diffusion-limited ion flow through pores

1976 • 145 citations

Ionic selectivity, saturation, and block in gramicidin a channels

1978 • 145 citations

Hydrogen ion currents in rat alveolar epithelial cells

1991 • 137 citations

Proton conductance by the gramicidin water wire. Model for proton conductance in the F1F0 ATPases?

1991 • 137 citations

Proton conductance of the plasma membrane: properties, regulation, and functional role

1993 • 136 citations

Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge.

1988 • 132 citations

A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages.

1993 • 132 citations

Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles

1992 • 125 citations

Intrinsic gating of inward rectifier in bovine pulmonary artery endothelial cells in the presence or absence of internal Mg2+.

1990 • 124 citations

Proton currents in human granulocytes: regulation by membrane potential and intracellular pH.

1993 • 124 citations

The use of quartz patch pipettes for low noise single channel recording

1993 • 120 citations

Limitations of the whole cell patch clamp technique in the control of intracellular concentrations

1990 • 119 citations

Current understanding of the cellular biology and molecular structure of the antidiuretic hormone-stimulated water transport pathway.

1991 • 118 citations

The electrogenic Na/HCO3 cotransporter

1989 • 118 citations

A voltage‐gated hydrogen ion current in the oocyte membrane of the axolotl, Ambystoma.

1984 • 116 citations

Calcium–hydrogen exchange by the plasma membrane Ca-ATPase of voltage-clamped snail neurons

1993 • 113 citations

Voltage-dependent block by amiloride and other monovalent cations of apical Na channels in the toad urinary bladder

1984 • 110 citations

Theory of passive proton conductance in lipid bilayers

1987 • 104 citations

The Role of the Electrochemical Gradient in Determining Potassium Fluxes in Frog Striated Muscle

1968 • 96 citations

Voltage‐dependent intracellular pH in Helix aspersa neurones.

1987 • 93 citations

Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

1991 • 92 citations

Spectroscopically evaluated rates and energies for proton transfer and Bjerrum defect migration in cubic ice

1984 • 92 citations

A model for anomalous rectification: Electrochemical-potential-dependent gating of membrane channels

1978 • 88 citations

How pore mouth charge distributions alter the permeability of transmembrane ionic channels

1987 • 87 citations

Characterization of proton currents in neurones of the snail, Lymnaea stagnalis.

1989 • 82 citations

How do protons cross the membrane-solution interface? Kinetic studies on bilayer membranes exposed to the protonophore S-13 (5-chloro-3-tert-butyl-2′-chloro-4′ nitrosalicylanilide)

1987 • 81 citations

Dependency of delta pH-relaxation across vesicular membranes on the buffering power of bulk solutions and lipids

1986 • 76 citations

Conformationally constrained α‐helical peptide models for protein ion channels

1990 • 75 citations

Arachidonic acid stimulates the plasma membrane H+ conductance of macrophages.

1994 • 75 citations

The resting potential of moth muscle fibre

1972 • 74 citations

Phorbol 12-myristate 13-acetate activates an electrogenic H+-conducting pathway in the membrane of neutrophils

1992 • 72 citations

Dynamics of ion transport systems in membranes

1987 • 72 citations

Hopping of ions in ice

1974 • 70 citations

The NADPH-oxidase-associated H+ channel is opened by arachidonate

1992 • 69 citations

Use of weak acids to determine the bulk diffusion limitation of H+ ion conductance through the gramicidin channel

1988 • 69 citations

Volume changes and potential artifacts of epithelial cells of frog skin following impalement with microelectrodes filled with 3m KCl

1978 • 67 citations

Proton conductance through phospholipid bilayers: Water wires or weak acids?

1987 • 66 citations

The Effect of Zinc on Calcium and Hydrogen Ion Currents in Intact Snail Neurones

1989 • 65 citations

A voltage‐dependent proton current in cultured human skeletal muscle myotubes.

1993 • 62 citations

Inward rectification in skeletal muscle: A blocking particle model

1978 • 60 citations

Characterization of Na+-H+ antiport in type II alveolar epithelial cells

1987 • 58 citations

Hydrogen ion block of the sodium pore in squid giant axons.

1983 • 58 citations

Cytoplasmic hydrogen ion diffusion coefficient

1992 • 55 citations

Cl-/HCO3- exchange modulates intracellular pH in rat type II alveolar epithelial cells.

1988 • 54 citations

Use of a Fixed Charge Model to Determine the pK of the Negative Sites on the External Membrane Surface

1970 • 54 citations

Vasopressin increases water permeability by inducing pores

1980 • 52 citations

Notiz über Ionengeschwindigkeiten

1905 • 52 citations

Proteolipid of adenosinetriphosphatase from yeast mitochondria forms proton-selective channels in planar lipid bilayers

1982 • 52 citations

Mechanisms of potassium channel block in rat alveolar epithelial cells.

1990 • 51 citations

Proton channel of the chloroplast ATP synthase, CF0: Its time-averaged single-channel conductance as function of pH, temperature, isotopic and ionic medium composition

1989 • 49 citations

Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

1993 • 49 citations

Quantitation of physical-chemical properties of the aqueous phase inside the phoE ionic channel

1992 • 47 citations

Changes in membrane hydrogen and sodium conductances during progesterone-induced maturation of Ambystoma oocytes

1984 • 43 citations

Changes in the surface pH of voltage‐clamped snail neurones apparently caused by H+ fluxes through a channel.

1988 • 43 citations

The permeability of sodium channels to hydrogen ions in nerve fibres

1983 • 43 citations

Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils.

1994 • 42 citations

Membrane currents of internally perfused neurones of the snail, Lymnaea stagnalis, at low intracellular pH.

1986 • 40 citations

Complete tracking of proton flow in thylakoids‐the unit conductance of CF₀ is greater than 10 fS

1986 • 37 citations

Protons, the Thylakoid Membrane, and the Chloroplast ATP Synthase^a

1989 • 36 citations

Water, proton, and urea transport in toad bladder endosomes that contain the vasopressin-sensitive water channel.

1990 • 36 citations

Proton channels, plasma membrane potential, and respiratory burst in human neutrophils

1993 • 35 citations

The Mechanism of Proton Translocation in Reversible Proton-Translocating Adenosine Triphosphatases

1974 • 34 citations

Electrostatic radius of the gramicidin channel determined from voltage dependence of H+ ion conductance

1988 • 33 citations

Origin of the potassium and voltage dependence of the cardiac inwardly rectifying K-current (IK1)

1992 • 33 citations

Single channel H+ currents through reconstituted chloroplast ATP synthase CF0-CF1.

1989 • 32 citations

ATP-sensitive Na(+)-H+ antiport in type II alveolar epithelial cells

1991 • 32 citations

Evidence for active H+ secretion by rat alveolar epithelial cells

1989 • 32 citations

Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons

1993 • 32 citations

Elevation in intracellular calcium activates both chloride and proton currents in human macrophages

1994 • 29 citations

Regulation of lung surfactant secretion by intracellular pH

1989 • 29 citations

Separation of Hydrogen Ion Currents in Intact Molluscan Neurones

1989 • 27 citations

Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents

1989 • 26 citations

Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells

1994 • 26 citations

Common channels for water and protons at apical and basolateral cell membranes of frog skin and urinary bladder epithelia. Effects of oxytocin, heavy metals, and inhibitors of H(+)-adenosine triphosphatase.

1991 • 24 citations

A scheme to account for the effects of Rb+ and K+ on inward rectifier K channels of bovine artery endothelial cells.

1994 • 22 citations

Cation channels by subunit III of the channel portion of the chloroplast H⁺‐ATPase

1989 • 22 citations

Na(+)-HCO3- symport modulates intracellular pH in alveolar epithelial cells

1991 • 21 citations

Proton Channels in Snail Neurones Does Calcium Entry Mimic the Effects of Proton Influx?^a

1989 • 19 citations

Effect of high pH on the plasma membrane potential and conductance in Elodea densa

1992 • 18 citations

pH recovery from intracellular alkalinization in Retzius neurones of the leech central nervous system.

1993 • 14 citations

Intracellular pH in the OK cell. I. Identification of H+ conductance and observations on buffering capacity

1991 • 14 citations

Effect of changes in extracellular potassium on intracellular pH in principal cells of frog skin

1992 • 10 citations

Transport of the neutral form of amphiphilic drugs through a planar bilayer lipid membrane

1990 • 6 citations

Membranes, Gates, and Channels

1986 • 6 citations

Recovery of pHi in snail neurones exposed to high external potassium [proceedings].

1979 • 5 citations

Biochemical separation of delayed rectifier currents in frog short skeletal muscle fibres.

1985 • 4 citations

Voltage Sensitivity of the Na+/K+ Pump: Structural Implications

1994 • 4 citations

Recovery of pHi in snail neurones exposed to high external potassium [proceedings].

1979 • 3 citations

Elements of proton pump models.

1984 • 1 citations