Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca2+-depleted human neutrophils

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels

1984 • 334 citations

The superoxide-forming enzymatic system of phagocytes

1988 • 315 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Relationship of protein phosphorylation to the activation of the respiratory burst in human neutrophils. Defects in the phosphorylation of a group of closely related 48-kDa proteins in two forms of chronic granulomatous disease.

1988 • 181 citations

A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease.

1986 • 168 citations

Respiratory burst oxidase and three of four oxidase-related polypeptides are associated with the cytoskeleton of human neutrophils.

1991 • 148 citations

Endogenous protein phosphorylation by resting and activated human neutrophils

1983 • 143 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

Surface‐reactive stimuli selectively increase protein phosphorylation in human neutrophils

1981 • 134 citations

Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease.

1988 • 127 citations

Inhibition of Rap1A Binding to Cytochrome b ₅₅₈ of NADPH Oxidase by Phosphorylation of Rap1A

1991 • 120 citations

Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells

1989 • 117 citations

Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils

1986 • 111 citations

Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium

1990 • 106 citations

Characterization of the 47-Kilodalton Autosomal Chronic Granulomatous Disease Protein: Tissue-Specific Expression and Transcriptional Control by Retinoic Acid

1990 • 93 citations

1-O-Hexadecyl-2-O-methylglycerol, a Novel Inhibitor of Protein Kinase C, Inhibits the Respiratory Burst in Human Neutrophils

1989 • 89 citations

Complete dissociation between the activation of phosphoinositide turnover and of NADPH oxidase by formyl-methionyl-leucyl-phenylalanine in human neutrophils depleted of Ca2+ and primed by subthreshold doses of phorbol 12,myristate 13,acetate

1986 • 79 citations

Phorbol 12, myristate 13, acetate potentiates the respiratory burst while inhibits phosphoinositide hydrolysis and calcium mobilization by formyl-methionyl-leucyl-phenylalanine in human neutrophils

1986 • 73 citations

Changes in diacylglycerol labeling, cell shape, and protein phosphorylation distinguish “triggering” from “activation” of human neutrophils.

1988 • 72 citations

Activation of protein kinase C in neutrophil cytoplasts

1985 • 68 citations

Effects of antagonists of protein phosphatases on superoxide release by neutrophils.

1992 • 67 citations

Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils

1990 • 66 citations

Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils

1990 • 54 citations

Protein Phosphorylation Associated with Synergistic Stimulation of Neutrophils

1989 • 49 citations

Fluoride can activate the respiratory burst independently of Ca 2+ , stimulation of phosphoinositide turnover and protein kinase C translocation in primed human neutrophils

1988 • 46 citations

Double stimulation with FMLP and Con A restores the activation of the respiratory burst but not of the phosphoinositide turnover in Ca2+-depleted human neutrophils. A further example of dissociation between stimulation of the NADPH oxidase and phosphoinositide turnover

1986 • 42 citations

Independence with respect to Ca2+ changes of the neutrophil respiratory and secretory response to exogenous phospholipase C and possible involvement of diacylglycerol and protein kinase C

1985 • 37 citations

Phosphorylation of both 47 and 49kDa proteins accompanies superoxide release by neutrophils

1989 • 34 citations

Charge-dependent regulation of NADPH oxidase activities in intact and subcellular systems of polymorphonuclear leukocytes

1988 • 27 citations

Isolation of the respiratory burst oxidase: The role of a flavoprotein component

1988 • 20 citations

Translocation of the 46 kDa Protein(s) in Response to Activation of NADPH Oxidase in Guinea Pig Polymorphonuclear Leukocytes1

1990 • 15 citations