HIV-1 envelope glycoproteins-mediated apoptosis is regulated by CD4 dependent and independent mechanisms

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.

1996 • 499 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals

1993 • 464 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines

1996 • 367 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

CD26: a surface protease involved in T-cell activation

1994 • 330 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease

1990 • 281 citations

Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles

1992 • 274 citations

A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

1991 • 255 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections.

1994 • 250 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes.

1991 • 208 citations

DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.

1990 • 185 citations

Inositol phosphates and Ca ²⁺ entry: toward a proliferation or a simplification?

1992 • 184 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

Apoptosis II: The Molecular Basis of Apoptosis in Disease

1994 • 126 citations

Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1

1992 • 98 citations

Caenorhabditis elegansのunc‐13遺伝子がコードするホルボールエステル/ジアシルグリセロール結合蛋白質

1991 • 98 citations

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion

1993 • 91 citations

From AIDS to Parasite Infection: Pathogen‐Mediated Subversion of Programmed Cell Death as a Mechanism for Immune Dysregulation

1994 • 89 citations

HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells.

1994 • 87 citations

Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes.

1996 • 86 citations

Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules

1995 • 85 citations

Use of a novel human immunodeficiency virus type 1 reporter virus expressing human placental alkaline phosphatase to detect an alternative viral receptor

1995 • 81 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

CD4+ blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells.

1995 • 78 citations

gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.

1994 • 70 citations

Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1

1995 • 64 citations

Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells

1995 • 62 citations

The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: Possible involvement of protein kinase C pathway

1990 • 51 citations

Dipeptidyl‐Peptidase IV‐β, a Novel form of Cell‐Surface‐Expressed Protein with Dipeptidyl‐Peptidase IV Activity

1996 • 50 citations

HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.

1996 • 50 citations

p56lck plays a key role in transducing apoptotic signals in T cells

1995 • 49 citations

Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells

1995 • 45 citations

Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death.

1995 • 44 citations

Endocytic and Exocytic Regulation of CD4 Expression and Function

1996 • 41 citations

Cell-to-Cell Fusion, but Not Virus Entry in Macrophages by T-Cell Line Tropic HIV-1 Strains: A V3 Loop-Determined Restriction

1995 • 39 citations

Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV‐1 gp120

1995 • 39 citations

CD26 induces T-cell proliferation by tyrosine protein phosphorylation.

1992 • 39 citations

HIV-2 EHO Isolate Has a Divergent Envelope Gene and Induces Single Cell Killing by Apoptosis

1994 • 38 citations

Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules

1995 • 35 citations

Function of Dipeptidyl Peptidase IV (CD26, Tp103) in Transfected Human T Cells

1993 • 33 citations

The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells

1994 • 32 citations

HIV Envelope Glycoprotein-Induced Cell Killing by Apoptosis Is Enhanced with Increased Expression of CD26 in CD4+T Cells

1996 • 31 citations

The cytopathic effect of human immunodeficiency virus is independent of high levels of unintegrated viral DNA accumulated in response to superinfection of cells

1993 • 29 citations

Killing of primary CD4+ T cells by non-syncytium-inducing macrophage-tropic human immunodeficiency virus type 1.

1994 • 29 citations

HIV-induced syncytium formation requires the formation of conjugates between virus-infected and uninfected T-cells in vitro

1991 • 27 citations

HIV envelope-directed signaling aberrancies and cell death of CD4⁺ T cells in the absence of TCR co-stimulation

1996 • 24 citations

Different proliferative response of human and chimpanzee lymphocytes after contact with human immunodeficiency virus type 1 gp120

1994 • 24 citations

The relationship between AIDS and immunologic tolerance.

1992 • 22 citations

Analysis of the human immunodeficiency virus type 1 envelope protein interaction with the CD4 host cell receptor

1994 • 14 citations

CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line.

1994 • 11 citations