Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Nucleotide sequence of the AIDS virus, LAV

1985 • 1,225 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Death and the cell

1986 • 616 citations

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

1988 • 608 citations

ASSOCIATION BETWEEN BIOLOGICAL PROPERTIES OF HUMAN IMMUNODEFICIENCY VIRUS VARIANTS AND RISK FOR AIDS AND AIDS MORTALITY

1989 • 581 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Inhibition of Entry of HIV-1 in Neural Cell Lines by Antibodies Against Galactosyl Ceramide

1991 • 523 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

Epitopes of the CD4 Antigen and HIV Infection

1986 • 379 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

1991 • 326 citations

CD4+ Lymphocyte Cell Enumeration for Prediction of Clinical Course of Human Immunodeficiency Virus Disease: A Review

1992 • 313 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Detection of Human Immunodeficiency Virus Type 1 Provirus in Mononuclear Cells by in Situ Polymerase Chain Reaction

1992 • 305 citations

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

1991 • 295 citations

Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity

1992 • 259 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Infectious Mutants of HTLV-III with Changes in the 3′ Region and Markedly Reduced Cytopathic Effects

1986 • 236 citations

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS

1988 • 223 citations

Characterization of HIV-1 neutralization escape mutants

1989 • 220 citations

Immunopathogenesis of HIV infection

1991 • 213 citations

LAV Revisited: Origins of the Early HIV-1 Isolates from Institut Pasteur

1991 • 210 citations

Cytotoxic T lymphocytes against HIV

1990 • 180 citations

CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor

1990 • 174 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1

1988 • 163 citations

A major mechanism of human immunodeficiency virus-induced cell killing does not involve cell fusion

1987 • 154 citations

Sera from HTLV-III/LAV antibody-positive individuals mediate antibody-dependent cellular cytotoxicity against HTLV-III/LAV-infected T cells.

1987 • 154 citations

Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins

1989 • 152 citations

REGULATION OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

1991 • 135 citations

Neutralizing monoclonal antibodies to the AIDS virus

1988 • 124 citations

Inhibition of lymphoproliferation by a synthetic peptide with sequence identity to gp41 of human immunodeficiency virus type 1

1989 • 117 citations

Improved antigenicity of the HIV env protein by cleavage site removal

1988 • 111 citations

Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype

1992 • 102 citations

AIDS virus env Protein Expressed from a Recombinant Vaccinia Virus

1986 • 97 citations

Cytopathic effect of human immunodeficiency virus in T4 cells is linked to the last stage of virus infection.

1988 • 94 citations

A specific inhibitor of cysteine proteases impairs a Vif-dependent modification of human immunodeficiency virus type 1 Env protein

1991 • 77 citations

Structure and function of the HIV envelope

1989 • 72 citations

Loss of CD4 membrane expression and CD4 mRNA during acute human immunodeficiency virus replication.

1988 • 70 citations

Five epitopes of a differentiation antigen on human inducer T cells distinguished by monoclonal antibodies

1983 • 69 citations

Defective signal transduction—a common pathway for cellular dysfunction in HIV infection?

1990 • 69 citations

Potential mechanisms for the cytopathic properties of HIV

1989 • 69 citations

Glucosidase Inhibitors for Treatment of HIV-1 Infection

1992 • 66 citations

Characterization of human immunodeficiency virus type 2 envelope glycoproteins: dimerization of the glycoprotein precursor during processing

1989 • 64 citations

Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction.

1989 • 61 citations

Cloning and characterization of human immunodeficiency virus type 1 variants diminished in the ability to induce syncytium-independent cytolysis

1990 • 56 citations

Do CD4 and CD8 control T-cell activation via a specific tyrosine protein kinase?

1989 • 48 citations

Characterization of an HIV-2-related virus with a smaller sized extracellular envelope glycoprotein

1989 • 46 citations

Primary Cytotoxicity against the Envelope Glycoprotein of Human Immunodeficiency Virus-It Evidence for Antibody-Dependent Cellular Cytotoxicity In Vivo

1990 • 43 citations

Death and transfiguration of cortical thymocytes: a reconsideration

1990 • 42 citations

Cell surface expression of several species of human immunodeficiency virus type 1 major core protein

1989 • 38 citations

HIV-1 Core Proteins Expressed from Recombinant Vaccinia Viruses

1989 • 24 citations

How do human immunodeficiency viruses enter cells?

1987 • 23 citations

Human and murine monoclonal antibodies directed against a conserved sequence from gp41 (aa583–599) of human immunodeficiency virus type 1

1992 • 12 citations

Immune parameters in HIV infection — a practical guide

1991 • 3 citations