Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity

1988 • 754 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.

1985 • 545 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

1986 • 387 citations

Epitopes of the CD4 Antigen and HIV Infection

1986 • 379 citations

Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1

1989 • 338 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

1988 • 285 citations

Involvement of a Leukocyte Adhesion Receptor (LFA-1) in HIV-Induced Syncytium Formation

1989 • 264 citations

Irreversible inhibition of v-src tyrosine kinase activity by herbimycin a and its abrogation by sulfhydryl compounds

1989 • 217 citations

Wee1+-like gene in human cells

1991 • 211 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes.

1989 • 177 citations

An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins

1991 • 170 citations

Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein

1991 • 125 citations

Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.

1989 • 122 citations

HIV-1-Infected T Cells Show a Selective Signaling Defect After Perturbation of CD3/Antigen Receptor

1988 • 116 citations

Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission.

1991 • 109 citations

Unexpectedly High Levels of HIV-1 RNA and Protein Synthesis in a Cytocidal Infection

1988 • 109 citations

Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes

1991 • 91 citations

Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase.

1990 • 87 citations

Biochemical Characterization of the η Chain of the T-cell Receptor

1989 • 80 citations

Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line.

1990 • 32 citations