Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

Nucleotide sequence of the AIDS virus, LAV

1985 • 1,225 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

Apoptosis

1993 • 972 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Rosette-Forming Human Lymphoid Cell Lines. I. Establishment and Evidence for Origin of Thymus-Derived Lymphocytes<xref ref-type="fn" rid="FN1">2</xref>

1972 • 916 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy

1993 • 803 citations

Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus

1985 • 706 citations

Apoptosis and disease

1993 • 684 citations

Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome

1984 • 639 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization

1989 • 400 citations

Epitopes of the CD4 Antigen and HIV Infection

1986 • 379 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease

1990 • 281 citations

A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity.

1992 • 275 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

1990 • 268 citations

Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain

1991 • 219 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

Viral DNA and mRNA expression correlate with the stage of human immunodeficiency virus (HIV) type 1 infection in humans: evidence for viral replication in all stages of HIV disease

1992 • 166 citations

Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein

1991 • 125 citations

Reinfection results in accumulation of unintegrated viral DNA in cytopathic and persistent human immunodeficiency virus type 1 infection of CEM cells.

1990 • 107 citations

Human immunodeficiency virus (HIV-1) cytotoxicity: Perturbation of the cell membrane and depression of phospholipid synthesis

1988 • 98 citations

Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1

1992 • 98 citations

Accumulation of human immunodeficiency virus type 1 DNA in T cells: results of multiple infection events

1990 • 95 citations

Cytopathic effect of human immunodeficiency virus in T4 cells is linked to the last stage of virus infection.

1988 • 94 citations

Apoptosis II The molecular basis of apoptosis in disease

1995 • 92 citations

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion

1993 • 91 citations

Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1

1994 • 89 citations

Retroviruses of Human AIDS and Related Animal Diseases

2000 • 72 citations

HIV interactions with CD4: a continuum of conformations and consequences

1992 • 58 citations

Intracellular distribution of the envelope glycoprotein of human immunodeficiency virus and its role in the production of cytopathic effect in CD4+ and CD4- human cell lines

1990 • 55 citations

Dissociation of unintegrated viral DNA accumulation from single-cell lysis induced by human immunodeficiency virus type 1

1992 • 48 citations

The transmembrane glycoprotein of human immunodeficiency virus type 1 induces syncytium formation in the absence of the receptor binding glycoprotein

1992 • 39 citations

HIV-2 EHO Isolate Has a Divergent Envelope Gene and Induces Single Cell Killing by Apoptosis

1994 • 38 citations

Membrane alterations linked to early interactions of HIV with the cell surface

1992 • 35 citations

The cytopathic effect of human immunodeficiency virus is independent of high levels of unintegrated viral DNA accumulated in response to superinfection of cells

1993 • 29 citations

Detection of unintegrated human immunodeficiency virus type 1 DNA in persistently infected CD8+ cells

1993 • 27 citations

HIV-induced syncytium formation requires the formation of conjugates between virus-infected and uninfected T-cells in vitro

1991 • 27 citations

Deleted Work

1955 • 0 citations