Drosophila innate immunity: an evolutionary perspective

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides

1999 • 1,774 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Antimicrobial peptides in insects; structure and function

1999 • 1,001 citations

Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

1997 • 969 citations

NF-κB signaling pathways in mammalian and insect innate immunity

2001 • 892 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

2001 • 759 citations

Antimicrobial peptides in mammalian and insect host defence

1999 • 723 citations

Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

2001 • 687 citations

The evolution and genetics of innate immunity

2001 • 665 citations

Postembryonic Hematopoiesis in Drosophila

2001 • 609 citations

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

1995 • 590 citations

Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia

2000 • 588 citations

Conserved Role of a Complement-like Protein in Phagocytosis Revealed by dsRNA Knockout in Cultured Cells of the Mosquito, Anopheles gambiae

2001 • 519 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors

2000 • 475 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

1999 • 429 citations

Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis

2001 • 421 citations

A genome-wide analysis of immune responses in Drosophila

2001 • 393 citations

The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection

2000 • 391 citations

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

1998 • 382 citations

Toll-related receptors and the control of antimicrobial peptide expression inDrosophila

2000 • 380 citations

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

1996 • 357 citations

The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila

2000 • 353 citations

Interactions between the cellular and humoral immune responses in Drosophila

2000 • 343 citations

Cytotoxicity and cytotoxic molecules in invertebrates

2000 • 330 citations

Activation of the Drosophila NF‐κB factor Relish by rapid endoproteolytic cleavage

2000 • 322 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity

2000 • 306 citations

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses

2001 • 302 citations

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

2001 • 292 citations

Role of the integument in insect defense: pro-phenol oxidase cascade in the cuticular matrix.

1995 • 289 citations

Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila

2000 • 277 citations

A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis

1998 • 272 citations

Role of Drosophila IKKγ in a Toll-independent antibacterial immune response

2000 • 266 citations

Drosophila MyD88 is an adapter in the Toll signaling pathway

2001 • 262 citations

Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappa B factor

1999 • 261 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

κB-like Motifs Regulate the Induction of Immune Genes in Drosophila

1993 • 229 citations

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF

1999 • 210 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Role of the integument in insect immunity: epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells.

1993 • 196 citations

The antibacterial arm of the Drosophila innate immune response requires an IκB kinase

2001 • 187 citations

Drosophila immunity

1997 • 181 citations

Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube

1999 • 170 citations

Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila.

1993 • 159 citations

Induction and regulation of antimicrobial peptides in Drosophila

1999 • 156 citations

A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila

1980 • 151 citations

The Cellular Defense System of Drosophila melanogaster

1984 • 149 citations

The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

1994 • 141 citations

Signal transduction by a protease cascade

1999 • 119 citations

The Drosophila membrane receptor Toll can function to promote cellular adhesion.

1990 • 115 citations

The imd gene is required for local Cecropin expression in Drosophila barrier epithelia

2001 • 114 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

Interaction and Specificity of Rel-related Proteins in Regulating Drosophila Immunity Gene Expression

1999 • 112 citations

Getting knotted: a model for the structure and activation of Spätzle

1998 • 110 citations

Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae.

1996 • 109 citations

The Drosophila Toll Gene Functions Zygotically and Is Necessary for Proper Motoneuron and Muscle Development

1995 • 103 citations

The maternal NF-κB/Dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle

2000 • 86 citations

Independent evolution of Toll and related genes in insects and mammals

2000 • 79 citations

The Antimicrobial Host Defense of Drosophila

2000 • 72 citations

Oyster IKK‐like protein shares structural and functional properties with its mammalian homologues

1999 • 61 citations

Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube

1998 • 54 citations

Horseshoe Grab Coagulogen Is an Invertebrate Protein with a Nerve Growth Factor-Like Domain

1997 • 43 citations

THE THEORY OF THE DIFFUSE DOUBLE LAYER

1933 • 42 citations

Specificity of Rel-Inhibitor Interactions in Drosophila Embryos

1995 • 32 citations

Molecular Cloning and Characterization of SRAM, a Novel Insect Rel/Ankyrin-Family Protein Present in Nuclei

2000 • 11 citations