The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

The embryonic development of Drosophila melanogaster

1938 • 2,188 citations

The Embryonic Development of Drosophila melanogaster

1985 • 1,371 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

Detection in situ of genomic regulatory elements in Drosophila.

1987 • 773 citations

Immunological method for mapping genes on Drosophila polytene chromosomes.

1982 • 772 citations

Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.

1989 • 688 citations

P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

1989 • 679 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.

1986 • 533 citations

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

1990 • 499 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

Two types of amino acid substitutions in protein evolution

1979 • 463 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

1992 • 419 citations

Immune reactions in Drosophila and other insects: a model for innate immunity

1993 • 417 citations

The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins

1990 • 417 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis.

1992 • 403 citations

Sequence analysis and neuronal expression of fasciclin I in grasshopper and drosophila

1988 • 363 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

EGF‐like domains in extracellular matrix proteins: Localized signals for growth and differentiation?

1989 • 304 citations

Connectin: A homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila

1992 • 282 citations

slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system

1988 • 281 citations

Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man.

1988 • 257 citations

The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.

1992 • 233 citations

κB-like Motifs Regulate the Induction of Immune Genes in Drosophila

1993 • 229 citations

Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila

1988 • 228 citations

Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human

1988 • 218 citations

Homoeotic and atavic mutations in insects

1977 • 214 citations

Multiple functions of segment polarity genes in Drosophila

1987 • 212 citations

Fasciclin III: A novel homophilic adhesion molecule in Drosophila

1989 • 211 citations

Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila

1989 • 205 citations

The Properties and Turnover of Hyaluronan

2007 • 197 citations

Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction.

1992 • 180 citations

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation

1991 • 140 citations

Drosophila chaoptin, a member of the leucine-rich repeat family, is a photoreceptor cell-specific adhesion molecule.

1990 • 140 citations

Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation.

1988 • 134 citations

Making stripes inelegantly

1989 • 131 citations

Control of morphogenesis and differentiation by HOM/Hox genes

1993 • 128 citations

Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae.

1989 • 118 citations

The Drosophila membrane receptor Toll can function to promote cellular adhesion.

1990 • 115 citations

The effects of zygotic lethal mutations on female germ-line functions in Drosophila

1984 • 105 citations

Enhancer Trap Method in Drosophila: Its Application to Neurobiology

1992 • 98 citations

The Drosophila couch potato protein is expressed in nuclei of peripheral neuronal precursors and shows homology to RNA-binding proteins.

1992 • 94 citations

Knowing your neighbors: Cell interactions determine intrasegmental patterning in Drosophila

1992 • 86 citations

Molecular and Genetic Characterization of the Drosophila tartan Gene

1993 • 69 citations

Amphipathic beta structure of a leucine-rich repeat peptide.

1991 • 62 citations

The chicken IL-1 receptor: differential evolution of the cytoplasmic and extracellular domains

1992 • 52 citations

neuromusculin, a drosophila gene expressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule

1993 • 48 citations

TISSUE-SPECIFIC AND COMPLEX COMPLEMENTATION PATTERNS IN THE PUNCH LOCUS OF DROSOPHILA MELANOGASTER

1985 • 25 citations

CHROMOSOMAL CONTROL OF FERTILITY IN DROSOPHILA MELANOGASTER. I. RESCUE OF T(Y;A)/bb l-158 MALE STERILITY BY CHROMOSOME REARRANGEMENT

1984 • 16 citations