Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

1997 • 969 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

1995 • 590 citations

A family of peptidoglycan recognition proteins in the fruit flyDrosophila melanogaster

2000 • 525 citations

Relish, a Central Factor in the Control of Humoral but Not Cellular Immunity in Drosophila

1999 • 511 citations

A peptidoglycan recognition protein in innate immunity conserved from insects to humans

1998 • 471 citations

Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation

2000 • 432 citations

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

1999 • 429 citations

The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection

2000 • 391 citations

Toll-related receptors and the control of antimicrobial peptide expression inDrosophila

2000 • 380 citations

The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila

2000 • 353 citations

Mannose-binding lectin: structure, function, genetics and disease associations.

2000 • 310 citations

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses

2001 • 302 citations

Role of Drosophila IKKγ in a Toll-independent antibacterial immune response

2000 • 266 citations

Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappa B factor

1999 • 261 citations

Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth

2000 • 203 citations

The antibacterial arm of the Drosophila innate immune response requires an IκB kinase

2001 • 187 citations

Drosophila immunity: two paths to NF-κB

2001 • 160 citations

Innate recognition systems in insect immunity and development: new approaches in

2000 • 38 citations