Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Automated MAD and MIR structure solution

1999 • 3,079 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1997 • 1,724 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation

1991 • 1,123 citations

Modulation of life and death by the TNF receptor superfamily

1998 • 543 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1999 • 415 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

1996 • 379 citations

Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

1984 • 335 citations

An ancient system of host defense

1998 • 333 citations

Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment

1998 • 302 citations

NMR structure of the death domain of the p75 neurotrophin receptor

1997 • 301 citations

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

1998 • 235 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

1995 • 183 citations

Data Collection and Processing

1980 • 143 citations

Oligomerisation of Tube and Pelle leads to nuclear localisation of Dorsal

1999 • 127 citations

A Gradient of Cactus Protein Degradation Establishes Dorsoventral Polarity in theDrosophilaEmbryo

1996 • 124 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.

1994 • 103 citations

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators

1997 • 102 citations

The Solution Structure of FADD Death Domain

1999 • 102 citations

Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation

1999 • 85 citations

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.

1993 • 79 citations

Systematic Mutational Analysis of the Death Domain of the Tumor Necrosis Factor Receptor 1-associated Protein TRADD

1996 • 73 citations

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

1995 • 71 citations

Expression, purification, and crystallization of natural and selenomethionyl recombinant ribonuclease H from Escherichia coli.

1990 • 61 citations

Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo

1998 • 60 citations

Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.

1993 • 42 citations

dorsal, a Drosophila Rel-Like Protein, Is Phosphorylated upon Activation of the Transmembrane Protein Toll

1994 • 19 citations